Curcumin derivative HBC induces autophagy through activating AMPK signal in A549 cancer cells

Zhou, Guang‐Zhou; Sun, Gang‐Chun; Zhang, Shuai-Na

doi:10.1007/s13273-015-0004-8

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…Curcumin is widespread, inexpensive, and highly safe to human [ 7 ]. It is polyphenolic natural compound from Curcuma longa [ 8 ], with diverse drug activities against aging related events, including dermatologic changes [ 9 ], retinal diseases [ 10 ], Parkinson’s disease (PD) [ 11 ], renal antioxidative effect [ 12 ], ischemic oxidative damages in diverse organs [ 13 – 15 ], and cancers [ 16 ]. Curcumin analogues may facilitate degradation of androgen receptor (AR) in prostate cancer [ 17 ], and may induce apoptosis of prostate cancer cell by IkBalpha, c-Jun and androgen receptor [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Kim

Seok

Jeon

et al. 2015

BMC Complement Altern Med

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BackgroundBenign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress the development of BPH in male Wistar rats.MethodsSeven weeks male Wistar rats were and divided into 4 groups (normal group, BPH group, finasteride group, curcumin group; n = 8 for each group). In order to induce BPH in rats, rats were castrated and testosterone was injected subcutaneously everyday (s.c., 20 mg/kg). Rats in the curcumin group were treated 50 mg/kg, administered orally for 4 weeks. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed.ResultsCompared to the finasteride group as positive group, the curcumin group showed similarly protective effect on BPH in histopathologic morphology, prostate volume. Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ß1, and IGF1 were also decreased in the curcumin group.ConclusionsThese results suggested that curcumin inhibited the development of BPH and might a useful herbal treatment or functional food for BPH.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Kim

Seok

Jeon

et al. 2015

BMC Complement Altern Med

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“…HBC may prompt A549 cell death through an autophagy pathway as HBC action could be repealed by pre‐treating cells with wortmannin (100 nM), a typical autophagy inhibitor. It is likewise answered to increment autophagosome development and combination with lysosomes, recommending that HBC could build LC3‐II expression in a dose‐dependent manner (Zhou et al, 2015).…”

Section: Anticancer Activity Of Curcumin Analogues Via Different Mole...mentioning

confidence: 99%

Mechanism insights of curcumin and its analogues in cancer: An update

Joshi,

Verma,

Kumar Semwal

et al. 2023

Phytotherapy Research

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Cancer is the world's second leading cause of mortality and one of the major public health problems. Cancer incidence and mortality rates remain high despite the great advancements in existing therapeutic, diagnostic, and preventive approaches. Therefore, a quest for less toxic and more efficient anti‐cancer strategies is still at the forefront of the current research. Traditionally important, curcumin commonly known as a wonder molecule has received considerable attention as an anti‐cancer, anti‐inflammatory, and antioxidant candidate. However, limited water solubility and low bioavailability restrict its extensive utility in different pathological states. The investigators are making consistent efforts to develop newer strategies to overcome its limitations by designing different analogues with better pharmacokinetic and pharmacodynamic properties. The present review highlights the recent updates on curcumin and its analogues with special emphasis on various mechanistic pathways involved in anti‐cancer activity. In addition, the structure–activity relationship of curcumin analogues has also been precisely discussed. This article will also provide key information for the design and development of newer curcumin analogues with desired pharmacokinetic and pharmacodynamic profiles and will provide in depth understanding of molecular pathways involved in the anti‐cancer activities.

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Proteomic analysis of muscarinic acetylcholine receptor-mediated proliferation in HT-29 human colon cancer cells

Lee

Ahn

et al. 2018

Mol. Cell. Toxicol.

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Curcumin derivative HBC induces autophagy through activating AMPK signal in A549 cancer cells

Cited by 7 publications

References 22 publications

Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Mechanism insights of curcumin and its analogues in cancer: An update

Proteomic analysis of muscarinic acetylcholine receptor-mediated proliferation in HT-29 human colon cancer cells

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