Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

“…Inhibition of PGE 2 -miR-21 signaling restored PTEN levels to baseline and decreased AKT activation , which was mirrored by a drop in cell viability due to the augmented induction of apoptosis . These findings have been validated by other reports that causally related curcumin-induced apoptosis in Cancer Pharmacology of Curcumin cancer cells to suppressed PGE 2 synthesis Lee et al, 2009;Sreekanth et al, 2011) and/or decreased AKT phosphorylation Elamin et al, 2010;Watson et al, 2010a;Prakobwong et al, 2011;Wong et al, 2011). c. Angiogenesis (H-VII). The angiogenic switch (Bergers and Benjamin, 2003) is primarily triggered by VEGF (Keck et al, 1989;Leung et al, 1989), the expression of which is upregulated in most human cancers (Ferrara and Davis-Smyth, 1997).…”

Pharmacological treatment for uterine leiomyosarcomas

“…Curcumin, derived from the herb Curcuma longa, inhibits uterine LMS cell proliferation both in vitro and in vivo experimental models through AKT-mTOR pathway [105,106], and the m-TOR inhibitor everolimus decelerates LMS growth in mice and prolongs their lifespan [107]. Temserolimus obtained PR in three of six patients with advanced LMS refractory to standard chemotherapy [108].…”

Curcumin Effect on the Expressional Profile of OCT4, Nanog and Nucleostemin Genes in AGS (Adenocarcinoma) Cancer Cell Line

“…OCT4 gene includes three variants (A, B, B1), the OCT4B1 variant recently been detected and up-regulated in cancer cells [20]. The increase will vary according to grade that can be useful in cancer diagnosis and determine the degree of malignancy [12,23]. OCT4 gene includes three variants (A, B, B1), the variant OCT4B1 recently been detected in cancer cells express high.…”

“…Wong et al demonstrated that curcumin may induce apoptosis in specific doses in many cancer cells. Curcumin is the release of cytochrome c and stability of P53 [23]. Curcumin inhibits the transcriptional network in stages and thus prevents the cell proliferation [26].…”