Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer

Sen, Gouri Sankar; Mohanty, Suchismita; Hossain, Dewan Md Sakib; Bhattacharyya, Sankar; Banerjee, Shuvomoy; Chakraborty, Joydeep; Saha, Sujoy; Ray, Pallab; Bhattacharjee, Pushpak; Mandal, Deba Prasad; Bhattacharya, Arindam; Chattopadhyay, Samit; Das, Tanya; Sa, Gaurisankar

doi:10.1074/jbc.m111.262295

Cited by 104 publications

(87 citation statements)

References 60 publications

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“…Encapsulation by nanoparticles appears to be a brilliant advance to conquer the hydrophobicity of drugs. There are many encapsulation methods, such as spray-drying and solvent removal, to encapsulate CUR into micelles or liposomes (31,32). In this study, we used PCL-PEG-PCL micelles to encapsulate CUR.…”

Section: Discussionmentioning

confidence: 99%

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

HosseinDanafar

2016

Jundishapur J Nat Pharm Prod

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Background: Natural products derived from plants play a significant function in healthcare in many cultures, both ancient and modern. curcumin (CUR) is a chemical constituent of turmeric with anticancer activity, but its poor water solubility limits its use clinically. Methods: To improve the bioavailability and water solubility of curcumin, we synthesized five series of poly (caprolactone)-poly (ethylene glycol)-poly (caprolactone) (PCL-PEG-PCL) triblock copolymers. The structure of the copolymers was characterized by HNMR, FT-IR, DSC, and GPC techniques. The nanoparticles (NPs) were prepared using a solvent evaporation method. To achieve the best delivery system, we assigned the effect of the length of the copolymers' hydrophilic and hydrophobic chains on the encapsulation of hydrophobic CUR, performed entrapment efficiency and drug loading assignments, as well as evaluated the particle distribution and in vitro release using the direct dispersion method. Results: CUR was encapsulated with 71% and 83% efficiency in biodegradable nanoparticulate formulations, based on NP4 and NP5. Dynamic laser light scattering (DLS) indicated a particle diameter of 112 nm and 110 nm for NP4 and NP5, respectively. FT-IR and DSC analysis of the NPs showed that CUR was encapsulated into the NPs. The in vitro release experiments showed that NP5 controlled the release of CUR more effectively, with only 51% of CUR released after 120 hours. Conclusions:The results indicate the successful formulation of curcumin-loaded PCL-PEG-PCL nanoparticles and improved water solubility of curcumin, which may have potential application in cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

HosseinDanafar

2016

Jundishapur J Nat Pharm Prod

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“…All buffers were supplemented with protease and phosphatase inhibitor mixtures (15,16). Protein concentrations were estimated using micro Lowry method.…”

Section: Methodsmentioning

confidence: 99%

“…Since SMAR1 (Scaffold/Matrix attachment region-binding protein 1) has been documented to play key role in tumor regression (16) and interact with the tumor suppressor p53 and MDM2 independently, the motto of the present study is to investigate the possible role of SMAR1 in regulating the metastatic potential of different breast cancer cell lines and its correlation with the EMT marker, E-cadherin (17). Matrix attachment region (MAR)-binding proteins organize chromatin in loop domain structure thereby partitioning chromatin from actively transcribing regions to poorly transcribing regions (18,19).…”

mentioning

confidence: 99%

Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation

Adhikary

Chakraborty

Mazumdar

et al. 2014

Journal of Biological Chemistry

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Background: Epithelial-mesenchymal transition (EMT) is an important program in tumor metastasis. Results: SMAR1 inhibits EMT by up-regulating E-cadherin in a dual manner via repression of Slug transcription and inhibition of E-cadherin degradation. Conclusion: SMAR1 functions as a critical protein in regulating EMT. Significance: This study provides a potential mechanism for the contribution of SMAR1 in inhibiting breast cancer metastasis.

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“…It is one of the most widely employed chemotherapy agents for cancers, like breast cancer and liver cancer (Sen GS, et al, 2011). LncRNA H19 has been proved function as an oncogene.…”

Section: Doxorubicin Resistance and Lncrnasmentioning

confidence: 99%

Long Non-coding RNAs and Drug Resistance

Pan

Xie²,

Xu³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Long non-coding RNAs (lncRNAs) are emerging as key players in gene expression that govern cell developmental processes, and thus contributing to diseases, especially cancers. Many studies have suggested that aberrant expression of lncRNAs is responsible for drug resistance, a substantial obstacle for cancer therapy. Drug resistance not only results from individual variations in patients, but also from genetic and epigenetic differences in tumors. It is reported that drug resistance is tightly modulated by lncRNAs which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, and drug metabolism. In this review, we summarize recent advances in research on lncRNAs associated with drug resistance and underlying molecular or cellular mechanisms, which may contribute helpful approaches for the development of new therapeutic strategies to overcome treatment failure.

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Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer

Cited by 104 publications

References 60 publications

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation

Long Non-coding RNAs and Drug Resistance

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