Curcumin enhances the immunosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions

Chueh, Shih-Chieh; Lai, Ming-Kuen; Liu, I.-S; Teng, Fei; Chen, J

doi:10.1016/s0041-1345(03)00377-4

Cited by 25 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison, pharmacological safety of curcumin has been demonstrated by its consumption for centuries and by several clinical trials (43,44). Consistent with the early study showing that curcumin could enhance the immunosuppressive activity of CsA in rat cardiac allografts (17), we show that curcumin can enhance CsA-mediated suppression of T cell activation (Fig. 7).…”

Section: Discussionsupporting

confidence: 92%

“…This finding also provides the explanation for the observation that curcumin could prolong allografts observed in animal models (16,17). CsA and FK-506 (Tacrolimus) are calcineurin inhibitors used to prevent graft-versus-host disease in organ transplantations.…”

Section: Discussionmentioning

confidence: 64%

“…Along this line, pretreatment with curcumin was found to prolong skin graft survival in an animal model (16). A later study showed that curcumin could enhance the immunosuppressive activity of cyclosporine A (CsA) 2 in rat cardiac allografts (17). Moreover, curcumin was found to be a potent inhibitor of CsAresistant T cells in response to T cell activation (18).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation

Kliem

Merling

Giaisi

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Curcumin can overcome CsA resistance. However, the molecular mechanism is unknown. Results: Curcumin blocks T cell stimulation-induced Ca 2ϩ mobilization and thereby prevents NFAT activation, a mechanism different from CsA. Conclusion: Curcumin is an immunosuppressive phytochemical that blocks Ca 2ϩ signaling. Significance: The study demonstrates for the first time that curcumin is a potent inhibitor of NFAT activation via blocking Ca

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 64%

mentioning

confidence: 99%

See 1 more Smart Citation

Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation

Kliem

Merling

Giaisi

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…The assays were carried out on PMNs and human whole blood. Curcumin (Balasubramanyam et al, 2003;Chueh et al, 2003), ibuprofen (Stuhlmeier et al, 1999) and aspirin (Parij et al, 1998) were used as reference compounds based on reports of their roles in the inflammatory process.…”

Section: General Methodsmentioning

confidence: 99%

Immunomodulatory effects of diarylpentanoid analogues of curcumin

et al. 2015

View full text Add to dashboard Cite

Diarylpentanoid analogues of curcumin are known for their various pharmacological activities which include the inhibition of inflammatory mediators and are good candidates as immunomodulators that could be useful in the treatment of inflammation. In the work described here, seventeen diarylpentanoid curcumin analogues were assessed for their inhibitory effects on the reactive oxygen species (ROS) production, chemotaxis and phagocytosis of human neutrophils. ROS production was evaluated using luminol and lucigenin-based chemiluminesence assay, while inhibition of isolated polymorphonuclear neutrophils chemotaxis and phagocytosis abilities were investigated using the Boyden chamber technique and the Phagotest kit, respectively. Two of the analogues, compounds 1e and 2e, which contain the 2-methyl-4(N-ethyl-N-ethylacetonitrile)aniline functional group, were active in all the assays performed. Moreover, analogues containing heteroatoms (1a, 1e, 2c, 2d, 2e, 3a and 3c) were active in suppressing the neutrophil phagocytic activity. The information obtained gave new insight into curcumin analogues with the potential to be developed as new immunomodulators.

show abstract

“…55 Curcumin was also found by Chueh et al to enhance the immunosuppressive activity of cyclosporin in a heterotopic cardiac transplant model. 56 However, whether modulation of antigen-specific cell-mediated cytotoxity by curcumin played a role in the protection of transplants from rejection was not addressed in these studies. Gao et al investigated the regulation of development of alloantigen-specific and broadly nonspecific lymphokineactivated killer (LAK) cells by curcumin in vitro.…”

Section: Cell-mediated Cytotoxicitymentioning

confidence: 98%

Immunomodulation by Curcumin

Gautam¹,

Gao²,

Dulchavsky³

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Turmeric, the bright yellow spice extracted from the tuberous rhizome of the plant Curcuma longa, has been used in traditional Indian and Chinese systems of medicine for centuries to treat a variety of ailments, including jaundice and hepatic disorders, rheumatism, anorexia, diabetic wounds, and menstrual difficulties. Most of the medicinal effects of turmeric have been attributed to curcumin, the principal curcumanoid found in turmeric. Recent evidence that curcumin exhibits strong anti-inflammatory and antioxidant activities and modulates the expression of transcription factors, cell cycle proteins, and signal transducing kinases has prompted the mechanism-based studies on the potential of curcumin to primarily prevent and treat cancer and inflammatory diseases. Little work has been done to study the effect of curcumin on the development of immune responses. This review discusses current knowledge on the immunomodulatory effects of curcumin on various facets of the immune response, including its effect on lymphoid cell populations, antigen presentation, humoral and cell-mediated immunity, and cytokine production.

show abstract

Curcumin enhances the immunosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions

Cited by 25 publications

References 8 publications

Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation

Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation

Immunomodulatory effects of diarylpentanoid analogues of curcumin

Immunomodulation by Curcumin

Contact Info

Product

Resources

About