Curcumin Extract for Prevention of Type 2 Diabetes

Abstract

OBJECTIVETo assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetic population.RESEARCH DESIGN AND METHODSThis randomized, double-blinded, placebo- controlled trial included subjects (n = 240) with criteria of prediabetes. All subjects were randomly assigned to receive either curcumin or placebo capsules for 9 months. To assess the T2DM progression after curcumin treatments and to determine the number of subjects progressing to T2DM, changes in β-cell functions (homeostasis model assessment [HOMA]-β, C-peptide, and proinsulin/insulin), insulin resistance (HOMA-IR), anti-inflammatory cytokine (adiponectin), and other parameters were monitored at the baseline and at 3-, 6-, and 9-month visits during the course of intervention.RESULTSAfter 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05). The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P < 0.001) and higher adiponectin (22.46 vs. 18.45; P < 0.05) when compared with the placebo group.CONCLUSIONSA 9-month curcumin intervention in a prediabetic population significantly lowered the number of prediabetic individuals who eventually developed T2DM. In addition, the curcumin treatment appeared to improve overall function of β-cells, with very minor adverse effects. Therefore, this study demonstrated that the curcumin intervention in a prediabetic population may be beneficial.

The role of curcumin in liver diseases

“…In particular, there was observed an improvement in serum superoxide dismutase activities and a reduction in concentration malondialdehyde and C-reactive protein. These results are in line with previous studies [97].…”

Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes

“…The best-known mechanism is through its ability to modulate transcription factors such as nuclear factor (NF)-κB, activator protein 1 (AP-1), signal transducer and activator of transcription (STAT) and their downstream signalling pathways [13,14]. The hypothesis that administration of curcumin would ameliorate diabetes has been tested successfully in a murine model of insulin resistance [15] and in a clinical trial on T2DM prediabetic patients [16]. Its efficacy and safety has been tested previously in clinical trials [17,18].…”

Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

“…[44][45][46][47][48] Curcumin-treated prediabetic patients have shown a beneficial effect in reducing the development of diabetes with 9 months of intervention, along with a higher improvement in the β-cell functions. 49 Similarly, a resveratrol supplementation can enhance the antidiabetic effect in humans with a dose of 1 g for 45 days. 50 Quercetin is another flavonoid compound that showed a higher antidiabetic effect in streptozotocin-induced diabetic rats.…”