Curcumin improves early functional results after experimental spinal cord injury

Cemil, Berker; Topuz, Kivanc; Demircan, Mehmet; Kurt, Gökhan; Tun, Kağan; Kutlay, Murat; İpçioğlu, Osman Metin; Küçükodacı, Zafer

doi:10.1007/s00701-010-0702-x

Cited by 60 publications

(40 citation statements)

References 45 publications

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“…Both PTEN/Akt/mTOR signaling and neuronal activity play a role in phosphorylation and, [38,39]. Relevant to this study, it is interesting to note that in distinct type of cancer cells, curcumin increased levels of phospho-eIF4e [37], which we found to be downregulated in sensorimotor neocortices after SCI.…”

Section: Discussionsupporting

confidence: 66%

Acute adaptive responses of central sensorimotor neurons after spinal cord injury

Thompson

DiBona

Dubey

et al. 2010

Translational Neuroscience

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Spinal cord injury (SCI) can be a lifelong, devastating condition for both the patient and the caregiver, with a daunting incidence rate. Still, there are only limited available therapies and the effectiveness of precise regeneration within the central nervous system is minimal throughout postnatal life. Recently, improved regeneration after SCI was seen by manipulating a pathway in sensorimotor neocortices that is involved in phosphorylation of an RNA binding protein (RBP) required for mRNA translation, the Eukaryotic translation initiation factor 4E (eIF4E). Our data identifies rapid molecular alterations of eIF4E in the sensorimotor neocortices 1 and 3 days after a lateral hemisection SCI, used as a model for Brown-Séquard syndrome. The function of an RBP depends on both its distribution sites within the cell and its phosphorylation states. Indeed, we found both to be affected after SCI. There was a distinct subcellular redistribution of eIF4E and phosphorylated-eIF4E was reduced, indicating that the eIF4E's translation was disrupted. Upon identification and analysis of the mRNA cargo of eIF4E in uninjured sensorimotor neocortices, we found that eIF4E binds both Importin-13 (Ipo13) and Parvalbumin (Pv) mRNAs, indicating a role in their translation. Remarkably, eIF4E's interaction with both Ipo13 and Pv mRNAs was disrupted 1 and 3 days after SCI, despite preservation of total Ipo13 and Pv mRNA levels. Finally, we detected a selective loss of expression of both IPO13 and PV proteins in projection neurons of sensorimotor neocortices, as well as their disrupted dendritic polarity. Since IPO13 is predominantly expressed in neocortical projection neurons and PV in a subset of neocortical interneurons, these data suggest a strong acute effect of SCI on neocortical microcircuitry. Taken together, these data indicate that neocortical eIF4E and a subset of mRNAs may be rapidly recruited to translational machinery after SCI to promote adaptive regeneration response of sensorimotor neurons.

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Section: Discussionsupporting

confidence: 66%

Acute adaptive responses of central sensorimotor neurons after spinal cord injury

Thompson

DiBona

Dubey

et al. 2010

Translational Neuroscience

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“…In addition, biochemical analysis of the plasma and spinal cord tissue verified its systemic and local effects. Previously, Cemil et al 6 reported the neuroprotective effects of curcumin on experimental spinal cord injury induced by aneurysmal clipping. Thereafter, Lin et al 19 performed hemisection on the spinal cord and showed curcumin reduction of robust RANTES production in reactivated astrocytes both in vitro and in vivo may contribute to its neuroprotection and potential application in spinal cord ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…29,40 Extensive research within the past decade has established curcumin as a pleotropic molecule, which is useful for neurodegenerative, cardiovascular, pulmonary, metabolic, arthritic, and autoimmune diseases. 24 Cemil et al 6 showed neuroprotective effects of curcumin in an experimental spinal cord ischemia model.…”

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confidence: 99%

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

Kurt

Yıldırım²,

Cemil

et al. 2014

SPI

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Object. The object of this study was to conduct a prospective, randomized, laboratory investigation of the neuroprotective effects of curcumin functionally, biochemically, and histologically in an experimental acute spinal cord ischemia-reperfusion injury on rabbits.Methods. Eighteen rabbits were randomly assigned to 1 of 3 groups: the sham group, the ischemia-reperfusion group, or the curcumin group. Spinal cord ischemia was induced by applying an infrarenal aortic cross-clamp for 30 minutes. At 48 hours after ischemia, neurological function was evaluated with modified Tarlov criteria. Biochemical changes in the spinal cord and plasma were observed by measuring levels of malondialdehyde (MDA), advanced oxidation protein products (AOPP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitrite/nitrate, and tumor necrosis factor-a (TNF-a). Histological changes were examined with H & E staining. Immunohistochemical staining with antibodies against caspase-3 was performed to evaluate cell apoptosis after ischemia.Results. In the curcumin group, neurological outcome scores were statistically significantly better compared with the ischemia-reperfusion group. In the ischemia-reperfusion group, MDA, AOPP, and nitrite/nitrate levels were significantly elevated in the spinal cord tissue and the plasma by the induction of ischemia-reperfusion. The curcumin treatment significantly prevented the ischemia-reperfusion-induced elevation of nitrite/nitrate and TNF-a. In addition, the spinal cord tissue and the plasma SOD, GSH, and CAT levels were found to be preserved in the curcumin group and not statistically different from those of the sham group. Histological evaluation of the tissues also demonstrated a decrease in axonal damage, neuronal degeneration, and glial cell infiltration after curcumin administration.Conclusions. Although further studies including different dose regimens and time intervals are required, curcumin could attenuate a spinal cord ischemia-reperfusion injury in rabbits via reducing oxidative products and proinflammatory cytokines, as well as increasing activities of antioxidant enzymes and preventing apoptotic cell death. (http://thejns.org/doi/abs/10.3171/2013 keY WorDs • antioxidant • curcumin • ischemia-reperfusion injury • neuroprotection • oxidative stress • spinal cord injuryAbbreviations used in this paper: AOPP = advanced oxidation protein products; CAT = catalase; GSH = glutathione; MDA = malondialdehyde; SOD = superoxide dismutase; TBARS = thiobarbituric acid reactive substances; TNF = tumor necrosis factor.

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“…[11] In s study conducted by Cemil et al, post-SCI effects of curcumin and MP were compared in biochemical and histopathological terms. [12] Curcumin, another polyphenol, has antioxidative, anticancerous, and anti-inflammatory effects. In curcumin group, tissue malondialdehyde (MDA) level decreased and levels of antioxidant enzymes copper-zinc superoxide dismutase, catalase, and phospholipid hydroperoxide glutathione peroxidase increased.…”

Section: Discussionmentioning

confidence: 99%

Efficiacy Of Resveratrol And Quercetin After Experimental Spinal Cord İnjury

Çiftçi

Vural

et al. 2016

Ulus Travma Acil Cerrahi Derg

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Curcumin improves early functional results after experimental spinal cord injury

Abstract: This study showed the neuroprotective effects of curcumin on experimental SCI model. By increasing tissue levels of GSH-Px, SOD, and CAT, curcumin seems to reduce the effects of injury to the spinal cord, which may be beneficial for neuronal survival.

Cited by 60 publications

References 45 publications

Acute adaptive responses of central sensorimotor neurons after spinal cord injury

Acute adaptive responses of central sensorimotor neurons after spinal cord injury

Effects of curcumin on acute spinal cord ischemia-reperfusion injury in rabbits

Efficiacy Of Resveratrol And Quercetin After Experimental Spinal Cord İnjury

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