Curcumin improves liver damage in male mice exposed to nicotine

Abstract

The color of turmeric (薑黃 jiāng huáng) is because of a substance called curcumin. It has different pharmacological effects, such as antioxidant and anti-inflammatory properties. Nicotine is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in the liver and causes devastating effects. This study was designed to evaluate the protective role of curcumin against nicotine on the liver in mice.Forty-eight mice were equally divided into eight groups; control (normal saline), nicotine (2.5 mg/kg), curcumin (10, 30, and 60 mg/kg) and curcumin plus nicotine-treated groups. Curcumin, nicotine, and curcumin plus nicotine (once a day) were intraperitoneally injected for 4 weeks. The liver weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied.The results indicated that nicotine administration significantly decreased liver weight and increased the mean diameter of hepatocyte, central hepatic vein, liver enzymes level, and blood serum nitric oxide level compared with the saline group (p < 0.05). However, curcumin and curcumin plus nicotine administration substantially increased liver weight and decreased the mean diameter of hepatocyte, central hepatic vein, liver enzymes, and nitric oxide levels in all groups compared with the nicotine group (p < 0.05).Curcumin demonstrated its protective effect against nicotine-induced liver toxicity.

Effects of Curcumin on Tobacco Smoke-induced Hepatic MAPK Pathway Activation and Epithelial-Mesenchymal TransitionIn Vivo

“…Ricky et al have demonstrated that liver is pharmacological targets of dietary curcumin (Sharma et al, ). Salahshoor et al have found that curcumin (60 mg/kg BW) improves nicotine‐triggered liver damage in male mice (Salahshoor et al, ). Before feeding, curcumin was reformulated with corn oil in the current study.…”

The effect of green tea consumption on the expression of antioxidant‐ and inflammation‐related genes induced by nicotine

“…Every eight mice were grouped together forming four differently treated groups: Group I mice (control group) received tap water administered by gastric gavage at a dose of 1 ml/100 g body weight 1 hr before and 1 hr after each mouse was intraperitoneally injected with a phosphate buffered saline. Group II mice received GT solution administered by gastric gavage at a dose of 1 ml/100 g body weight twice a day 1 hr before and 1 hr after nicotine injection. Group III mice were injected intraperitoneally with nicotine (2.5 mg/kg) once per day and received tap water orally at a dose of 1 ml/100 g body weight 1 hr before and 1 hr after nicotine injection via gastric gavage. Group IV mice received both nicotine and GT. GT administered 1 hr before and 1 hr after nicotine injection via gastric gavage, treatment with nicotine dosage was based on a previous study (Salahshoor, Mohamadian, Kakabaraei, Roshankhah, & Jalili, ). …”

“…Group IV mice received both nicotine and GT. GT administered 1 hr before and 1 hr after nicotine injection via gastric gavage, treatment with nicotine dosage was based on a previous study (Salahshoor, Mohamadian, Kakabaraei, Roshankhah, & Jalili, 2016).…”

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“…[25,26] Curcumin Curcumin (Curcuma longa) possesses various biological activities such as anti-inflammatory, hepatoprotective, antibacterial, antidiabetic, antidepressant, analgesic, and anticarcinogenic. [27,28] The anti-inflammatory action of curcumin is attributed to inhibition of LOX, suppression of activation of NF-β, TNF-α, molecular adhesion, and inhibition of upregulation of matrix metalloproteinase (MMP-9) mRNA. It also promotes suppression of expression of TNF-α-induced MMP-13 in chondrocytes.…”