Curcumin improves metabolic response and increases expression of thermogenesis-associated markers in adipose tissue of male offspring from obese dams

Amaro, Lílian Betânia Reis; Jorge, Antônio Henrique Barcala; Lelis, Sarah de Farias; Lelis, Deborah de Farias; Guimarães, André Luiz Sena; Santos, Sérgio Henrique Sousa; Andrade, João Marcus Oliveira

doi:10.1016/j.mce.2022.111840

Cited by 12 publications

(5 citation statements)

References 54 publications

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“…As pro-oxidative environment-induced responses are implicated in MO offspring programming, the role of synthetic and natural antioxidants, such as N-acetyl cysteine (NAC) and curcumin, respectively, and their incorporation in the maternal diet during pregnancy has been explored [ 199 , 211 ]. Supplementation of NAC in C57/B6 pregnant MO mice induced through western diet (WD) and sucrose attenuated the left ventricular hypertrophy in 7-day-old MO-offspring, decreasing heart weight, collagen content, and interventricular septal thickness, and prevented the overexpression of genes of the NADPH oxidases (NOX) enzyme complex (e.g., Ncf2, Cyba, Rac1), especially in males.…”

Section: Intervention Strategies For Addressing the Metabolic Derange...mentioning

confidence: 99%

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

et al. 2023

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Obesity incidence has been increasing at an alarming rate, especially in women of reproductive age. It is estimated that 50% of pregnancies occur in overweight or obese women. It has been described that maternal obesity (MO) predisposes the offspring to an increased risk of developing many chronic diseases in an early stage of life, including obesity, type 2 diabetes, and cardiovascular disease (CVD). CVD is the main cause of death worldwide among men and women, and it is manifested in a sex-divergent way. Maternal nutrition and MO during gestation could prompt CVD development in the offspring through adaptations of the offspring’s cardiovascular system in the womb, including cardiac epigenetic and persistent metabolic programming of signaling pathways and modulation of mitochondrial metabolic function. Currently, despite diet supplementation, effective therapeutical solutions to prevent the deleterious cardiac offspring function programming by an obesogenic womb are lacking. In this review, we discuss the mechanisms by which an obesogenic intrauterine environment could program the offspring’s cardiovascular metabolism in a sex-divergent way, with a special focus on cardiac mitochondrial function, and debate possible strategies to implement during MO pregnancy that could ameliorate, revert, or even prevent deleterious effects of MO on the offspring’s cardiovascular system. The impact of maternal physical exercise during an obesogenic pregnancy, nutritional interventions, and supplementation on offspring’s cardiac metabolism are discussed, highlighting changes that may be favorable to MO offspring’s cardiovascular health, which might result in the attenuation or even prevention of the development of CVD in MO offspring. The objectives of this manuscript are to comprehensively examine the various aspects of MO during pregnancy and explore the underlying mechanisms that contribute to an increased CVD risk in the offspring. We review the current literature on MO and its impact on the offspring’s cardiometabolic health. Furthermore, we discuss the potential long-term consequences for the offspring. Understanding the multifaceted effects of MO on the offspring’s health is crucial for healthcare providers, researchers, and policymakers to develop effective strategies for prevention and intervention to improve care.

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Section: Intervention Strategies For Addressing the Metabolic Derange...mentioning

confidence: 99%

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

et al. 2023

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“…Santos et al. ( 2023 ) orally gavaged Swiss mice exposed to a hyperglycaemic diet with curcumin during pregnancy and lactation. However, the supplementation regime was only implemented in mice receiving the hyperglycaemic diet, and it was not possible to determine the impact of curcumin on a standard diet.…”

Section: Dietary Interventionsmentioning

confidence: 99%

“…Less is known in relation to its role in adipose tissue, but several in vitro studies have shown promotion of beige adipogenesis and suppression of adipocyte differentiation (Jin et al, 2018) making it a potential candidate for impacting adipose tissue development in utero. Santos et al (2023) orally gavaged Swiss mice exposed to a hyperglycaemic diet with curcumin during pregnancy and lactation.…”

Section: Curcuminmentioning

confidence: 99%

Developmentally programmed obesity: Is there a role for anti‐inflammatory nutritional strategies?

Kearns,

Reynolds

2023

Experimental Physiology

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Pregnancy represents a period of immense maternal physiological adaptation, with progressive increases in lipid storage potential and insulin resistance to support fetal/placental growth. This requires significant change in the adipose tissue. Women living with obesity/overweight are more susceptible to these changes causing complications such as gestational diabetes. This is particularly worrying as up to 60% of European women are living with overweight/obesity at the onset of pregnancy. Furthermore, less than 1% meet all nutrition guidelines. There is now evidence that these deep metabolic changes can result in a predisposition to metabolic disease in both the mother and child in later life. Health and nutrition status during this period therefore represents a window to future health. This period offers a valuable opportunity for intervention to prevent the negative consequences of poor in utero environments and increases the long‐term quality of life for mother and offspring. This review will examine a range of in utero factors which determine adipose tissue development, the impact of these factors on later‐life obesity and metabolic health and the therapeutic value of dietary anti‐inflammatory nutritional interventions during pregnancy and early life. When it comes to early life nutrition, a ‘one size fits all’ approach is not always appropriate. Understanding the mechanisms of adipose tissue development in response to differing nutritional strategies may be important in the context of complicated or adverse in utero environments and represents a substantial step towards a more personalised nutritional approach for the prevention of obesity, metabolic syndrome and related non‐communicable diseases in future generations.

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Section: Curcuminmentioning

confidence: 99%

“…Similar to resveratrol, curcumin administration via orogastric gavage in mothers on an HFD demonstrated the capacity to enhance insulin sensitivity and activate thermogenesis in brown adipose tissue (BAT) and WAT in male mice offspring (Figure 2) [150]. This effect is achieved by increasing the expression of thermogenic genes, such as PRDM16 and UCP-1 [150]. These favorable outcomes are likely to contribute to the improvement of mitochondrial function and energy expenditure in offspring born to mothers following an HFD [142], which have been suggested to be impaired by MO [66].…”

Section: Curcuminmentioning

confidence: 99%

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Diniz,

Magalhães,

Tocantins

et al. 2023

Nutrients

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Chronic diseases represent one of the major causes of death worldwide. It has been suggested that pregnancy-related conditions, such as gestational diabetes mellitus (GDM), maternal obesity (MO), and intra-uterine growth restriction (IUGR) induce an adverse intrauterine environment, increasing the offspring’s predisposition to chronic diseases later in life. Research has suggested that mitochondrial function and oxidative stress may play a role in the developmental programming of chronic diseases. Having this in mind, in this review, we include evidence that mitochondrial dysfunction and oxidative stress are mechanisms by which GDM, MO, and IUGR program the offspring to chronic diseases. In this specific context, we explore the promising advantages of maternal antioxidant supplementation using compounds such as resveratrol, curcumin, N-acetylcysteine (NAC), and Mitoquinone (MitoQ) in addressing the metabolic dysfunction and oxidative stress associated with GDM, MO, and IUGR in fetoplacental and offspring metabolic health. This approach holds potential to mitigate developmental programming-related risk of chronic diseases, serving as a probable intervention for disease prevention.

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Curcumin improves metabolic response and increases expression of thermogenesis-associated markers in adipose tissue of male offspring from obese dams

Cited by 12 publications

References 54 publications

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Developmentally programmed obesity: Is there a role for anti‐inflammatory nutritional strategies?

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

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