Curcumin improves the integrity of blood–spinal cord barrier after compressive spinal cord injury in rats

Yu, Deshui; Cao, Yang; Mei, Xifan; Wang, Yanfeng; Fan, Zhongkai; Wang, Yansong; Lv, Gang

doi:10.1016/j.jns.2014.07.056

Cited by 29 publications

(20 citation statements)

References 37 publications

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“…TNF-α was shown to be reduced by curcumin on days 1 and 14 of treatment. Similarly, a recent study has shown that curcumin treatment significantly reduced the elevated levels of the pro-inflammatory cytokine TNF-α and NF-κB expression generated by SCI within 24 h of treatment [ 25 ]. Curcumin treatment significantly decreased the expression of nuclear NF-κB ( Figure 2 ) and lowered the activity of the NF-kB pathway, as also confirmed by gene expression analysis ( Figure 5 ).…”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

Urdzíková

Karova

Růžička

et al. 2015

IJMS

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Abstract:Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9-T10 of the spinal cord, namely vehicle-or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1α, IL-2, and RANTES production and by decreasing NF-κB activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury.

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Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

Urdzíková

Karova

Růžička

et al. 2015

IJMS

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“…Evans blue (EB) was used as a marker of albumin extravasation and EB leakage was detected to evaluate BSCB permeability. EB injection and sample collection were conducted as previously reported (Yu et al, 2014). Results were expressed as μg EB/g spinal cord tissue.…”

Section: Methodsmentioning

confidence: 99%

Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects

Du¹,

Wang²,

Shang³

et al. 2016

Acta Biochim Pol

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Spinal cord injury (SCI) is one of the most severe traumatic injuries that results in dysfunction of limbs and trunk below the damaged section. Recent studies have shown that gastrodin (GAS) could improve the recovery of SCI. In the current study, we aimed to examine the possible mechanism underlying the effect of GAS on recovery of SCI in rats. In rats with SCI, GAS improved locomotor functions and decreased permeability of blood-spinal cord barrier, as illustrated by increase of Basso-Beattie-Bresnahan scores and decrease of Evans blue leakage. In addition, GAS inhibited inflammation, as evidenced by decrease of proinflammatory cytokines, including tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β) in rats following SCI. Moreover, increase of TBARS content and decrease of glutathione (GSH) content and superoxide dismutase (SOD) activities in SCI rats were inhibited by GAS. Furthermore, GAS enhanced mRNA expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), catalytic subunit of γ-glutamylcysteine ligase (GCLc) and modified subunit of γ-glutamylcysteine ligase (GCLm). The data suggested that GAS may promote the recovery of SCI through the enhancement of Nrf2-GCLc/GCLm signaling pathway, and subsequent improvement of oxidative stress and inflammation, resulting in decrease of permeability of BSCB and improved recovery of locomotor function in rats with SCI. The results have provided novel insights into GAS-related therapy of SCI and associated neurodegenerative diseases.

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“…Lanthanum ion is an electron-opaque tracer, which is widely used to examine the integrity of the BBB by transmission electron microscope. Another vascular tracer often used to detect the permeability by extravasation into brain or spinal parenchyma is the Evans blue (EB)·Compared with the normal spinal cord, the EB resulted markedly increased in the ischemia injury [19,20].One of the main reasons for the increased permeability of the BSCB is the reduction of the expression of claudins, occludin, and ZO-1, along with the increase in gaps between endothelial cells. This phenomenon results in inflammatory cells infiltration, such as neutrophils and macrophages into the spinal cord.…”

Section: Functional Changementioning

confidence: 99%

Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury

Xie

et al. 2016

Life Sciences

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Curcumin improves the integrity of blood–spinal cord barrier after compressive spinal cord injury in rats

Cited by 29 publications

References 37 publications

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects

Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury

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