Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

Ashrafizadeh, Milad; Zarrabi, Ali; Hashemi, Farid; Moghadam, Ebrahim Rahmani; Hashemi, Fardin; Entezari, Maliheh; Hushmandi, Kiavash; Mohammadinejad, Reza; Najafi, Masoud

doi:10.1016/j.lfs.2020.117984

Cited by 115 publications

(58 citation statements)

References 186 publications

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“…Ashrafizadeh et al. [342] have combined curcumin as an anti-tumor and anti-inflammation agent with paclitaxel and reported this combination chemotherapy application successful in enhancing the anti-tumor potency and decreasing the primary side effects of single-paclitaxel administration.…”

Section: Recent Outcomes In the Application Of Combination Chemotheramentioning

confidence: 99%

Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?

Mollaei

Hassan

Khorshidi

et al. 2021

Translational Oncology

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Highlight Chemotherapeutic drugs are classified into alkylating substrates, antimetabolite agents, anti-tumor antibiotics, inhibitors of topoisomerase I and II, mitotic inhibitors, and corticosteroids. Most of the chemotherapeutic drugs act in a dose-dependent manner; they either stimulate apoptosis or chemoresistance. Two major complications during chemotherapy are chemoresistance and tumor relapse. We have discussed underlying intracellular signaling cascades responsible for these events. Combination chemotherapies, targeted therapies, and immunotherapies have represented more promising responses than single chemotherapy applications. The role of omics, next-generation sequencing (NGS), whole-exome sequencing (WES), and machine learning technologies in precision medicine are currently under investigations for overcoming chemoresistance and tumor relapse.

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Section: Recent Outcomes In the Application Of Combination Chemotheramentioning

confidence: 99%

Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?

Mollaei

Hassan

Khorshidi

et al. 2021

Translational Oncology

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“…However, paclitaxel has some side effects such as neurotoxicity, hepatotoxicity, cardiotoxicity etc, demanding innovative approaches to avoid these issues. Ashrafizadeh et al, (2020) demonstrated that curcumin is able to suppress paclitaxel resistance and attenuate its side effects. To the best of our knowledge, there are no degree-based topological results available on the molecular structure of HA-curcumin conjugate in the literature.…”

Section: Motivationmentioning

confidence: 99%

Degree-based topological indices and polynomials of hyaluronic acid-curcumin conjugates

Ali

Kirmani

Rugaie

et al. 2020

Saudi Pharmaceutical Journal

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Quantitative structure–activity relationship (QSAR) represents quantitative correlation of chemical structural features called as molecular descriptors and pharmacological activity as response endpoints. Topological index is a molecular descriptor extensively used to study QSAR of pharmaceuticals to assess their molecular characteristics by numerical computation. Theoretical assessment of drug like molecules helps to expedite the drug design and discovery process by rationalizing the lead identification, lead optimization and understanding their mechanism of actions. Therefore, in this article, we have computed the general inverse sum indeg index, of Hyaluronic acid-curcumin conjugates by using molecular structure analysis and edge partitioning technique. Many standard topological indices are obtained as a special case of . We also proposed general inverse sum indeg polynomial of Hyaluronic acid-curcumin conjugates from which many well-known polynomials are deduced.

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“…Notably, curcumin has been shown to suppress the progression of lung cancer cells, such as proliferation, 10 migration and invasion, 11 and induces apoptosis 12 . Furthermore, curcumin has been indicated to hold versatile role in lung cancer 13 and various studies have suggested that curcumin might be used in cancer therapy 14 . What is more, curcumin or its derivatives have been elucidated to attenuate the stemness or CSC‐like phenotype in thyroid cancer cells, 15 glioblastoma cells 16 and hepatocellular carcinoma cells 17 .…”

Section: Introductionmentioning

confidence: 99%

“…12 Furthermore, curcumin has been indicated to hold versatile role in lung cancer 13 and various studies have suggested that curcumin might be used in cancer therapy. 14 What is more, curcumin or its derivatives have been elucidated to attenuate the stemness or CSC-like phenotype in thyroid cancer cells, 15 glioblastoma cells 16 and hepatocellular carcinoma cells. 17 However, it is still unclear whether curcumin can suppress the CSClike traits in NSCLC cells.…”

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confidence: 99%

Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ

Zheng

Yang

Tan

et al. 2021

Environmental Toxicology

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Curcumin has been shown to suppress the progression of lung cancer, however, the underlying mechanisms are largely unknown. Here, we aimed to investigate the effects of curcumin on the stemness of non-small cell lung cancer (NSCLC) cells. We found that curcumin reduced the sphere formation ability at the concentrations without affecting the cell viability of NSCLC cells and normal pulmonary epithelial cells, which is evident by the decrease of sphere size and number. In addition, curcumin decreased ALDH activity and the expression of stemness markers (CD133, EpCAM, Oct4). RNA sequencing analysis revealed that the Hippo pathway was mostly enriched in cells with curcumin treatment. Indeed, the expression of cancer stem cell markers was significantly decreased by curcumin treatment by analyzing the RNA sequencing data. Gene set enrichment analysis (GSEA) showed that curcumin negatively regulated the cancer stem cell function and positively modulated cancer stem cell differentiation ability. Furthermore, curcumin enhanced the cisplatin sensitivity of NSCLC cells. Mechanistically, it was found that curcumin promoted the nuclearcytoplasm translocation of TAZ, but not YAP, the critical effectors of Hippo pathway.In addition, curcumin destabilzed TAZ protein stability and promoted TAZ protein degradation in lung cancer cells, which is dependent on the proteasome degradation system, not by autophagy lysosome degradation system. Overexpression of TAZ rescued the inhibition of curcumin on the stemness of lung cancer cells. Thus, our results suggest that curcumin can attenuate the stemness of lung cancer cells through promoting TAZ protein degradation and thus activating Hippo pathway.

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Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

Cited by 115 publications

References 186 publications

Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?

Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?

Degree-based topological indices and polynomials of hyaluronic acid-curcumin conjugates

Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ

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