Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges

Wang, Wei; Li, Mingqin; Wang, Lingzhi; Chen, Lu; Goh, Boon Cher

doi:10.1016/j.canlet.2023.216332

Cited by 25 publications

(9 citation statements)

References 105 publications

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“…This NRF2 upregulation triggers ferroptosis, characterized by iron accumulation, ROS generation, lipid peroxidation, and GSH depletion. The study also validated the inhibition of tumor growth and induction of ferroptosis in vivo (Wang, Li, Wang, Chen, & Goh, 2023; Wang, Li, Wang, Chen, Li, et al, 2023; Wang, Li, Wang, Zhu, Liu, et al, 2023; Wang, Lin, Huang, Liu, Chen, et al, 2023; Wang, Liu, Li, Zha, Chen, et al, 2023; Wang, Shen, Lian, Deng, Qu, et al, 2023; Wang, Tan, Zhang, Wu, & Shi, 2023; Wang, Wan, Peng, Zhao, Bai, & Hu, 2023). ISL inhibits ferroptosis in the context of lipopolysaccharide (LPS)‐induced acute kidney injury by specifically targeting the protein NCOA4.…”

Section: Flavonoids and Ferroptosis In Cancersupporting

confidence: 57%

“…But the targets that through them ferroptosis is inhibited are different from those in cancer cells. In acute lung injury and Parkinson's disease, the main mechanism is attributed to the activation of NRF2 signaling (Deng et al, 2023; Lin et al, 2022), while in asthma and spinal cord injury, these effects are exerted through suppressing the immune response and, Id2/transferrin pathway, respectively (Wang, Li, Wang, Chen, & Goh, 2023; Wang, Li, Wang, Chen, Li, et al, 2023; Wang, Li, Wang, Zhu, Liu, et al, 2023; Wang, Lin, Huang, Liu, Chen, et al, 2023; Wang, Liu, Li, Zha, Chen, et al, 2023; Wang, Shen, Lian, Deng, Qu, et al, 2023; Wang, Tan, Zhang, Wu, & Shi, 2023; Wang, Wan, Peng, Zhao, Bai, & Hu, 2023). This dual role, modulating NRF2 signaling, suppressing immune response, or affecting specific pathways, emphasizes the need for a nuanced understanding of quercetin's effects in different contexts.…”

Section: Flavonoids and Ferroptosis In Cancermentioning

confidence: 99%

“…Amentoflavone (AMF) is a natural biflavonoid compound isolated from plants such as ginkgo, hinoki, and St. John's wort (Tuli et al, 2023). Its anticancer features have been linked to its ability to induce cell cycle arrest, apoptosis, and autophagy alongside hindering metastasis and angiogenesis via modulating pathways such as the AMPK/mTOR pathway (Xiong et al, 2021), which is implicated in ferroptosis as well (Wang, Li, Wang, Chen, & Goh, 2023; Wang, Li, Wang, Chen, Li, et al, 2023; Wang, Li, Wang, Zhu, Liu, et al, 2023; Wang, Lin, Huang, Liu, Chen, et al, 2023; Wang, Liu, Li, Zha, Chen, et al, 2023; Wang, Shen, Lian, Deng, Qu, et al, 2023; Wang, Tan, Zhang, Wu, & Shi, 2023; Wang, Wan, Peng, Zhao, Bai, & Hu, 2023). AMF has been shown to cause ferroptotic death in gastric cancer via downregulating a transcription factor named ATF2 and decreasing its target genes, including GPX4 and SLC7A11.…”

Section: Flavonoids and Ferroptosis In Cancermentioning

confidence: 99%

“…Its capacity to function as an antioxidant, anti‐inflammatory agent, and direct inhibitor of tumors, makes it a promising avenue for cancer therapy, demonstrating effectiveness against diverse cancer types in experimental studies (Ren et al, 2021). There are some evidence that have highlighted the ferroptosis suppressive function of resveratrol in human diseases such as ischemia–reperfusion injury (Liu, An, et al, 2022; Liu, Qi, et al, 2022; Liu, Wei, & Li, 2022; Liu, Wu, et al, 2022; Liu, Zhang, et al, 2022; Wang, Li, Wang, Chen, & Goh, 2023; Wang, Li, Wang, Chen, Li, et al, 2023; Wang, Li, Wang, Zhu, Liu, et al, 2023; Wang, Lin, Huang, Liu, Chen, et al, 2023; Wang, Liu, Li, Zha, Chen, et al, 2023; Wang, Shen, Lian, Deng, Qu, et al, 2023; Wang, Tan, Zhang, Wu, & Shi, 2023; Wang, Wan, Peng, Zhao, Bai, & Hu, 2023), heart failure (Zhang et al, 2023), and oxygen–glucose deprivation/reoxygenation (Zhu et al, 2022), due to its activatory effect on sirtuins (as master regulators of antioxidative response) (Wang, Li, Wang, Chen, & Goh, 2023; Wang, Li, Wang, Chen, Li, et al, 2023; Wang, Li, Wang, Zhu, Liu, et al, 2023; Wang, Lin, Huang, Liu, Chen, et al, 2023; Wang, Liu, Li, Zha, Chen, et al, 2023; Wang, Shen, Lian, Deng, Qu, et al, 2023; Wang, Tan, Zhang, Wu, & Shi, 2023; Wang, Wan, Peng, Zhao, Bai, & Hu, 2023; Zhang et al, 2023). However, induction of ferroptosis by resveratrol in tumors seems to be promising as cancer cells are more dependent on iron.…”

Section: Stilbenes and Ferroptosis In Cancermentioning

confidence: 99%

“…In osteoarthritis, curcumin safeguards chondrocytes from erastin‐induced ferroptosis by upregulating the Nrf2 signaling pathway, which in turn reverses lipid ROS and Fe 2+ production (Zhou, Jia, et al, 2023). Additionally, curcumin's protective role extends to ligature‐induced periodontitis, where it inhibits ferroptosis in periodontal‐diseased mice by reducing MDA levels and modulating key ferroptosis‐related proteins, including ACSL4, SLC7A11, GPX4, and TfR1 (Wang, Li, Wang, Chen, & Goh, 2023; Wang, Li, Wang, Chen, Li, et al, 2023; Wang, Li, Wang, Zhu, Liu, et al, 2023; Wang, Lin, Huang, Liu, Chen, et al, 2023; Wang, Liu, Li, Zha, Chen, et al, 2023; Wang, Shen, Lian, Deng, Qu, et al, 2023; Wang, Tan, Zhang, Wu, & Shi, 2023; Wang, Wan, Peng, Zhao, Bai, & Hu, 2023). In hepatolenticular degeneration, curcumin's efficacy lies in its ability to expel copper and inhibit ferroptosis through the Nrf2/HO‐1/GPX4 signaling pathway (Sun et al, 2023).…”

Section: Curcumin and Ferroptosis In Cancermentioning

confidence: 99%

See 4 more Smart Citations

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated cell death characterized by iron‐dependent lipid peroxidation. This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well‐known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron‐dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis‐mediated cancer therapy.

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Section: Flavonoids and Ferroptosis In Cancersupporting

confidence: 57%

Section: Flavonoids and Ferroptosis In Cancermentioning

confidence: 99%

Section: Flavonoids and Ferroptosis In Cancermentioning

confidence: 99%

Section: Stilbenes and Ferroptosis In Cancermentioning

confidence: 99%

Section: Curcumin and Ferroptosis In Cancermentioning

confidence: 99%

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Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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Chinese Medicines and Natural Medicine as Immunotherapeutic Agents for Gastric Cancer: Recent Advances

Zhang,

Chen,

Que

et al. 2024

Cancer Reports

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BackgroudAccording to the 2020 statistics from the World Health Organization’s International Agency for Research on Cancer (IARC), it is projected that there will be over 1 million new cases of gastric cancer (GC) patients worldwide in 2020, resulting in approximately 770 000 deaths. Gastric cancer ranks fifth in terms of incidence rate and forth in death rate among malignant tumors. Despite advancements in early diagnostic techniques, the incidence of GC has exhibited a marginal decline; nevertheless, the mortality rate remains elevated for advanced inoperable patients with no currently available efficacious treatment options.Recent FindingChinese medicine (CM) has emerged as an efficacious treatment for GC, gradually gaining acceptance and widespread usage in China. It exhibits distinctive advantages in the prevention and treatment of metastasis. CM and natural medicine possess the ability to elicit antitumor effects by augmenting immune cell population, enhancing immune cell activity, and improving the tumor immune microenvironment. CMs and natural remedies encompass a diverse range of types, characterized by multiple targets, pathways, and extensive pharmacological effects. Consequently, they have become a prominent research area among oncologists worldwide. Numerous studies have demonstrated that CM and natural medicine can directly or indirectly enhance innate immune system components (including macrophages, natural killer cells, and myeloid suppressor cells), adaptive immune system elements (such as T lymphocytes and regulatory T cells), relevant cytokines (e.g., IL‐2, IL‐4, IL‐10, TNF‐α), and PD‐1/PD‐L1 axis regulation, thereby bolstering the cytotoxicity of immune cells against tumor cells.ConclusionsThis ultimately leads to an improved tumor immune microenvironment facilitating superior antitumor efficacy. This paper critically examines the role of CM and natural medicine in regulating immunotherapy for GC, aiming to establish a new theoretical framework for the clinical treatment and prevention of gastric cancer within the realm of CM.

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Exploring the Interaction of Lipid Bilayers with Curcumin–Laponite Nanoparticles: Implications for Drug Delivery and Therapeutic Applications

Pawar,

Peña‐Figueroa,

Verde‐Sesto

et al. 2024

Small

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Curcumin, the active compound in turmeric, is renowned for its anti‐inflammatory, antioxidant, and antimicrobial properties, making it beneficial for treating conditions like arthritis, neurodegenerative diseases, and various cancers. Despite its promising therapeutic potential, curcumin's poor bioavailability—due to its rapid metabolism and low solubility—limits its clinical efficacy. To address this, recent research has focused on enhancing curcumin delivery using nanoparticles, liposomes, and novel nanomaterials. Among these, laponite, a synthetic nanoclay, has shown promise in improving curcumin delivery due to its unique properties, including large surface area, dual charge, and stability in solution. This study explores the use of curcumin–laponite nanoparticles as carrier vehicles for controlled delivery to in vitro model membranes. Utilizing advanced techniques such as neutron reflectometry, atomic force microscopy, quartz crystal microbalance with dissipation, and infrared spectroscopy, the interaction between curcumin–laponite nanoparticles and solid‐supported lipid bilayers is monitored, revealing enhanced stability and controlled release of curcumin across the membrane. These findings pave the way for the development of curcumin‐based therapies targeting cardiovascular, neurological, and oncological diseases, leveraging the synergistic effects of curcumin's biological activity and laponite's delivery capabilities.

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Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges

Cited by 25 publications

References 105 publications

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Chinese Medicines and Natural Medicine as Immunotherapeutic Agents for Gastric Cancer: Recent Advances

Exploring the Interaction of Lipid Bilayers with Curcumin–Laponite Nanoparticles: Implications for Drug Delivery and Therapeutic Applications

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