Curcumin in combination with anti-cancer drugs: A nanomedicine review

Batra, Harshul; Pawar, Shrikant; Bahl, Dherya

doi:10.1016/j.phrs.2018.11.005

Cited by 135 publications

(80 citation statements)

References 157 publications

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“…To solve this limitation, many researchers have focused on non‐platinum natural product‐based drugs containing a metal. Curcumin and its derivatives have anticancer activity on different types of cancer including melanoma, head and neck, breast, colon, pancreatic, genitourinary, gastrointestinal, lung, prostate, and ovarian cancers . There exist quite diverse mechanisms of action of curcumin as it pertains to anticancer activity.…”

Section: Anticancer Activitymentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Section: Anticancer Activitymentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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“…Nanomedicine is bridging the gap between pharmaceutical limitations and the therapeutic potentials of natural phytochemicals by improving the compound's targeting, pharmacokinetics, efficacy, and cellular uptake [73][74][75][76][77][78][79][80]. Many studies have focused on CUR nanotechnology mediated drug delivery formulations in optimization the therapeutics uses of CUR for various diseases, such as cancer therapy [81][82][83][84][85][86][87][88][89][90], neurodegenerative disorders [91,92], wound healing [93], diabetes [94,95], and inflammatory diseases [96]. A wide variety of nanomedicine-based drug delivery systems are used to deliver CUR such as liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, dendrosomes, nanogels, micelles, niosomes, cyclodextrin inclusion complexes, silver and gold nanoparticles, carbon nanotubes, nanoemulsions, nanosuspensions, exosomes, nanocrystals, and mesoporous silica nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…In the oral route, the bioavailability is enhanced by nanocarriers after improving solubility, protecting the drug from degradation in the gastrointestinal environment, and enhancing permeation in the small intestine; leading to an increase of drug levels in the blood stream [105]. Other emerging goals of nanocarriers is to achieve co-delivery of CUR with other drugs as an adjunct combinations therapy as an effective strategy to combat multi drug resistance [83,88]. Nanocarriers are also used to decrease the nonspecific drug uptake to undesirable tissues that leads to decreased toxicity [106,107].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

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Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre-and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

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“…The three major chemical constituents and biological activities of turmeric were approximately 77% curcumin (CUR), 17% demethoxycurcumin (DMC), and 3% bisdemethoxycurcumin (BDMC), which are belong to curcuminoids [1,2]. Cur, a linear diarylheptanoid, is a natural phenolic compound and it has been well known and used to treat many diseases, such as cancer [3][4][5][6], diabetes [7,8], inflammation [1] and neurodegenerative disorders [9,10]. In spite of the potential health benefits of CUR, its clinical applications are limited due to its low oral bioavailability, low water solubility, and instability at acidic Ph [11,12].…”

Section: Introductionmentioning

confidence: 99%

Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and –independent apoptosis via Smad or Akt signaling pathways in HOS cells

Huang

Chen

et al. 2020

BMC Complement Med Ther

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Background: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents and has also been associated with a high degree of malignancy and enhanced metastatic capacity. Curcumin (CUR) is well known for its anti-osteosarcoma activity. However, both demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are natural curcumin analogues/congeners from turmeric whose role in osteosarcoma development remains unknown. Methods: To evaluate the growth inhibitory effects of CUR, DMC and BDMC on osteosarcoma (HOS and U2OS), breast (MDA-MB-231), and melanoma (A2058) cancer cells, we employed the MTT assay, annexin V-FITC /7-AAD staining, and clonogenic assay. Results: CUR,DMC, and BDMC all decreased the viability of HOS, U2OS, MDA-MB-231, and A2058 cancer cells. Additionally, CUR,DMC, and BDMC induced the apoptosis of HOS cells through activation of Smad 2/3 or repression of Akt signaling pathway. Furthermore, the combination of CUR,DMC, and BDMC synergistically reduced cell viability, colony formation and increased apoptosis than either two or a single agent in HOS cells. Conclusions: The combination of these three compounds could be used as a novel target for the treatment of osteosarcoma.

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Curcumin in combination with anti-cancer drugs: A nanomedicine review

Cited by 135 publications

References 157 publications

Biological properties of metal complexes of curcumin

Biological properties of metal complexes of curcumin

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and –independent apoptosis via Smad or Akt signaling pathways in HOS cells

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