Curcumin in Osteosarcoma Therapy: Combining With Immunotherapy, Chemotherapeutics, Bone Tissue Engineering Materials and Potential Synergism With Photodynamic Therapy

Abstract

Osteosarcoma is a dominating malignant bone tumor with high mortality due to pulmonary metastases. Furthermore, because of the cancer cell erosion and surgery resection, osteosarcoma always causes bone defects, which means dysfunction and disfigurement are seldom inevitable. Although various advanced treatments (e.g. chemotherapy, immunotherapy, radiotherapy) are coming up, the 5-year survival rate for osteosarcoma with metastases is still dismal. In line with this, the more potent treatments for osteosarcoma are in high demand. Curcumin, a perennial herb, has been reportedly applied in the therapy of various types of tumors via different mechanisms. In vitro, it has also been reported that curcumin can inhibit the proliferation of osteosarcoma cell lines and can be used to repair bone defects. This seems curcumin is a promising candidate in osteosarcoma treatment. However, due to its congenital property like hydrophobicity, and low bioavailability, affecting its anticancer effect, clinical applications of curcumin are highly limited. To enhance its performance in cancer therapies, some synergist approaches with curcumin have emerged. The present review presents some prospective ones (i.e. combinations with immunotherapy, chemotherapeutics, bone tissue engineering, and biomaterials) applied in osteosarcoma treatment. Additionally, with the advancements of photodynamic therapy in cancer therapy, this review also prospects the combination of curcumin with photodynamic therapy in osteosarcoma treatment.

A relevância da educação para a saúde coletiva

“…O osteosarcoma é um tumor ósseo maligno dominante com elevada mortalidade devido a metástases pulmonares [79,81]. A curcumina, uma erva perene, tem sido alegadamente aplicada na terapia de vários tipos de tumores através de diferentes mecanismos [80,90,91]. Ela pode inibir a proliferação das linhas celulares do osteosarcoma e pode ser utilizada para reparar defeitos ósseos [81,90].…”

“…A curcumina, uma erva perene, tem sido alegadamente aplicada na terapia de vários tipos de tumores através de diferentes mecanismos [80,90,91]. Ela pode inibir a proliferação das linhas celulares do osteosarcoma e pode ser utilizada para reparar defeitos ósseos [81,90]. Observou-se que combinação das propriedades fotoativas da curcumina com a localização superficial do melanoma e da TFD parece ser um método de tratamento promissor [85].…”

Análise do perfil sociodemográfico, clínico e funcional de idosos com Doença de Parkinson

“…A curcumina é isolada do rizoma de Curcuma longa [81]. É um pigmento dietético que inibe a proliferação celular e induz a apoptose em diferentes linhas celulares [81,82,90,91]. O osteosarcoma é um tumor ósseo maligno dominante com elevada mortalidade devido a metástases pulmonares [79,81].…”

Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

“…Because of some curcumin disadvantages such as extensive first pass metabolism and poor bioavailability [ 63 ], conventional delivery strategies cannot overcome these problems. By incorporating curcumin in such materials, it can properly accumulate in the target area, resulting in a pharmacological potency boost [ 64 ].…”