Curcumin in Situ Gel for Local Treatment of Periodontitis: Preparation, in Vitro Evaluation and Clinical Assessment

Samal, Himansu Bhusan; Boyeena, Lavanya; Patra, Niranjan; Sriram, Sreenivas; Das, Itishree Jogamaya

doi:10.53879/id.59.11.13253

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…In order to allow the inert diffusion of the formulated herbal mouthwash, the agar plates were stored properly at 37° for 24 hours. The zones of inhibition were calculated inmm, the same procedure was carried out for commercially available mouthwash, and zones of inhibition (ZOI) were calculated in mm 31 .…”

Section: In-vitromentioning

confidence: 99%

Untitled

2023

IJPSR

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The current study aims to develop and evaluate herbal mouthwash and ascertain its effectiveness against microbes. Conventionally herbal mouthwashes are used as a disinfectant to lessen the presence of microbes in the oral cavity. Herbal mouthwashes act as a preventative agent for bleeding gums, decoloring teeth, and killing off bad breath germs. The herbal mouthwashes also have inherent benefits of plaque control and inflammation. The formulated mouthwash was prepared using herbs and the extract was extracted by hot water extraction method. Additional analysis of the Phyto ingredients was done where the flavonoid content and phenolic content was estimated as 41.71µg/ml and 76.25µg/ml, respectively and the in-vitro antibacterial assay was performed against Streptococcus mutans and Streptococcus salivarius and the zone of inhibition was calculated as 18mm and 22 mm at the highest concentration. The results indicated that the mouthwash exhibits effective antibacterial qualities. These solutions can be used for various things, including reducing the growth of germs in the oral cavity and for their analgesic, anti-inflammatory, or antifungal effects.

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Section: In-vitromentioning

confidence: 99%

Untitled

2023

IJPSR

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In situ Gels for Periodontitis: An Overview

Mallamma,

Rehman,

Goudanavar

et al. 2024

Asian Journal of Pharmaceutical Research and Health Care

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A successful approach for periodontitis treatment is in situ gel administration, which delivers medication to the site of infection in a controlled and continuous manner. Researchers used components such as zein, borneol, piperine, and curcumin to create a formulation. The formulations demonstrated antimicrobial effects and were designed to target the inflammatory condition associated with dysbiosis in periodontitis. Polymers such as gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly (D Lactic acid), poly (DL-lactide co glycolide), and polycaprolactone are commonly used polymers to prepare the In situ gel formulation , which enables prolonged medication and Controlled release. In the presence of ions, alginic acid gels are biocompatible. Whereas pectin gels are used in the presence of calcium ions, xyloglucan gels are used in response to temperature fluctuations. To increase the efficacy of the treatment, the studies sought to enhance gel characteristics such as gelation temperature, thickness, and drug release rate. The improved formulations showed anti-inflammatory solid effects and efficient drug delivery for periodontal conditions by significantly reducing pocket depth, plaque, and gum inflammation. The direct application of in situ gels offers targeted delivery, few side effects, and self-administration; the review focuses on the benefits, advantages, and disadvantages of in situ gel administration for periodontitis, as well as the characteristics of tooth physiology, preparation techniques, and polymers and biomarkers used. Assessments of in situ gels: To significantly improve periodontitis treatment, future research should focus on clinical studies to contribute substantially to periodontitis treatment.

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Assessment of Adherence to Medications and Prevalence of Depression Among Hemodialysis Patients

Mohammed,

Al-Hussaniy,

Oraibi

2024

IND. DRU.

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Hemodialysis patients often face challenges related to adherence to medications and psychological well-being, including depression. Understanding the prevalence of depression and adherence patterns among these patients is crucial for optimizing their care and improving outcomes. This study aimed to assess medication adherence and the prevalence of depression among hemodialysis patients compared to a control group of healthy volunteers. Additionally, sociodemographic and disease parameters were examined to identify potential correlations between depression and medication adherence. A total of 99 hemodialysis patients and 33 healthy volunteers were included in this comparative study. Depression prevalence was assessed using standardized scales and medication adherence was evaluated through self-reporting. Compared to the control group, which had a prevalence of 63.6%, hemodialysis patients had a depression prevalence of 86.9%. In addition, patients’ median depression scores were considerably greater than those of the control group. Nonetheless, there were no appreciable variations found in the sociodemographic and medical characteristics of individuals with and without depression. It was typical for individuals to not take their prescriptions as prescribed; 47.47% of them did not. The findings underscore the importance of routine screening for depression and interventions to enhance medication adherence in this population. Further research is warranted to explore the underlying factors contributing to depression and non-adherence among hemodialysis patients, with the aim of improving their overall quality of life and treatment outcomes.

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Curcumin in Situ Gel for Local Treatment of Periodontitis: Preparation, in Vitro Evaluation and Clinical Assessment

Cited by 3 publications

References 35 publications

Untitled

Untitled

In situ Gels for Periodontitis: An Overview

Assessment of Adherence to Medications and Prevalence of Depression Among Hemodialysis Patients

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