Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells

Zeng, Guohua; Dai, Hai-Ping; Jiang, Ou; Zhang, Qi; Zhai, Yunliang

doi:10.3109/13880209.2015.1060508

Cited by 35 publications

(33 citation statements)

References 24 publications

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“…SHI-1 is an acute monocytic leukaemia cell line that was originally derived from the mononuclear cells of the bone marrow of a 37-year-old male with M5b in relapse and has been maintained as a stable cell line in vitro; it has an abnormal t (6; 11) (q27; q23) translocation and expresses the pathogenic fusion product of MLL/AF6 (Chen et al 2005;Chen et al 2007). Previously, we showed that curcumin could inhibit the proliferation and induce the apoptosis of SHI-1 cells in vitro (Zhu et al 2016). In the present study, we confirmed that curcumin significantly induced apoptosis and partially suppressed the invasion of SHI-1 cells in vivo.…”

Section: Introductionsupporting

confidence: 85%

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cellsin vivoby altering MAPK and MMP signalling

Zeng

Jiang

et al. 2019

Pharmaceutical Biology

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Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute. Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo. Materials and methods: The SHI-1 cells (1 Â 10 6 cells in 0.1 mL PBS) were injected subcutaneously into the right flanks of the female SCID mice. Curcumin dissolved in olive oil (15 and 30 mg/kg) was administered (i.p.) to mice once a day for 15 days while the control group received olive oil injection. Tumour proliferation and apoptosis were examined by PCNA, TUNEL and cleaved caspase-3 staining. The expression of MAPK, NF-jB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting. Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg). Curcumin inhibited the expression of PCNA and increased the degree of TUNEL and cleaved caspase-3 staining in tumour tissue. The results of western blotting showed that curcumin treatment inhibited NF-jB and ERK signalling while activating p38 and JNK. Moreover, curcumin attenuated the mRNA transcription and protein expression of MMP2 and MMP9. Curcumin also suppressed the level of vimentin. Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target.

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Section: Introductionsupporting

confidence: 85%

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cellsin vivoby altering MAPK and MMP signalling

Zeng

Jiang

et al. 2019

Pharmaceutical Biology

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“…43 Zhu et al reported that curcumin induced apoptosis by inhibiting ERK expression and p38 activation in human monocytic leukemia cells. 44 We found that the anti-proliferative effect of UA on OSCC cells may be via the downregulation of ERK and p38 expression.…”

Section: Discussionmentioning

confidence: 72%

Ursolic acid induces apoptosis and autophagy in oral cancer cells

Lin

Chin

Lee

et al. 2019

Environmental Toxicology

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Oral squamous cell carcinoma (OSCC) is the fifth common cause of cancer mortality in Taiwan with high incidence and recurrence and needs new therapeutic strategies. In this study, ursolic acid (UA), a triterpenoid, was examined the antitumor potency in OSCC cells. Our results showed that UA inhibited the proliferation of OSCC cells in a dose‐ and time‐dependent manner in both Ca922 and SCC2095 oral cancer cells. UA induced caspase‐dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF‐κB signaling, ERK, and p38. In addition, UA inhibited angiogenesis as evidenced by abrogation of migration/invasion and blocking MMP‐2 secretion in Ca922 cells. Interestingly, UA induced autophagy in OSCC cells, as manifested by LC3B‐II conversion and increased p62 expression and accumulation of autophagosomes. Inhibition by autophagy inhibitor enhanced UA‐mediated apoptosis in Ca922 cells. The experiment provides a rationale for using triterpenoid in the treatment of OSCC.

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“…1 The anti-cancer compounds from Chinese herbal medicine (CHM). The popular anti-cancer compounds in CHM presented as a "word cloud", in which the size of each name is proportional to the number of publications of the compounds (NF-κB), signal transducer and activator of transcription and cell cycle-related proteins [36][37][38][39][40][41][42][43][44][45][46]. Curcumin is shown to induce anti-cancer activities through the disruption of mitochondrial membrane potential and blockade at G2/M phase of the cell cycle in human epidermoid carcinoma A-431 cells [47].…”

Section: Curcuminmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells

Cited by 35 publications

References 24 publications

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cellsin vivoby altering MAPK and MMP signalling

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cellsin vivoby altering MAPK and MMP signalling

Ursolic acid induces apoptosis and autophagy in oral cancer cells

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

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