Curcumin induces apoptosis in a murine mammary gland adenocarcinoma cell line through the mitochondrial pathway

Ibrahim, Abdelazim; El-meligy, Abdelmoniem; Lungu, Gina; Fetaih, Hamdy; Dessouki, Amina; Stoica, George; Barhoumi, Rola

doi:10.1016/j.ejphar.2011.06.048

Cited by 30 publications

(19 citation statements)

References 34 publications

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“…Curcumin mediated induction of apoptosis by depletion of reduced glutathione has not been observed in breast cancer. It not only decreases the viability of murine mammary gland adenocarcinoma cell line by inhibiting Bcl-2 (B-cell lymphoma 2) and activating caspase-3, it increases mitochondrial Ca 2+ and reactive oxygen species (ROS) production that act synergistically to produce the mitochondrial permeability transition and cell death [57]. It also induced apoptosis in breast cancer cells through up-regulating p21 expression [58].…”

Section: Introductionmentioning

confidence: 99%

Curcumin: the spicy modulator of breast carcinogenesis

Banik

Parasuraman

Adhikary

et al. 2017

J Exp Clin Cancer Res

127

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Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remained unconquered and the quest for cure is still going on. Present-day strategy of breast cancer therapy and prevention is either combination of a number of drugs or a drug that modulates multiple targets. In this regard natural products are now becoming significant options. Curcumin exemplifies a promising natural anticancer agent for this purpose. This review primarily underscores the modulatory effect of curcumin on the cancer hallmarks. The focus is its anticancer effect in the complex pathways of breast carcinogenesis. Curcumin modulates breast carcinogenesis through its effect on cell cycle and proliferation, apoptosis, senescence, cancer spread and angiogenesis. Largely the NFkB, PI3K/Akt/mTOR, MAPK and JAK/STAT are the key signaling pathways involved. The review also highlights the curcumin mediated modulation of tumor microenvironment, cancer immunity, breast cancer stem cells and cancer related miRNAs. Using curcumin as a therapeutic and preventive agent in breast cancer is perplexed by its diverse biological activity, much of which remains inexplicable. The information reviewed here should point toward potential scope of future curcumin research in breast cancer.

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Section: Introductionmentioning

confidence: 99%

Curcumin: the spicy modulator of breast carcinogenesis

Banik

Parasuraman

Adhikary

et al. 2017

J Exp Clin Cancer Res

127

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“…To study the effect of substituents at the aromatic rings regarding the attachment and detachment of an electron, we correlated the AEAs, VEAs, and VDEs with the Hammett sigma constant [27][28][29]. In both series, 1-6 and 7-12, we found for AEA a correlation coefficient (R 2 ) of 0.89 (1-6) and 0.90 (7)(8)(9)(10)(11)(12) for values calculated with the 6-31G(d) basis set and 0.94 (1-6) and 0.91 (7)(8)(9)(10)(11)(12) Compounds 4 and 10, with the strongest electro-donor p-N(CH 3 ) 2 group, on the aromatic rings, presented the lowest AEAs, followed by the unsubstituted compounds 1 and 7, and by the p-Cl compounds 2 and 8 and the p-Br derivatives 3 and 9, which can be considered weak electron-donor substituents at long distances. Compounds with strong electron-acceptor substituents as -CF 3 (6 and 12) and -CN (5 and 11) on para position of the aromatic rings had higher AEAs.…”

Section: Radical Anions and Electron Affinitiesmentioning

confidence: 93%

“…A currently active field of research deals with the multiple biological activities displayed by curcumin and their derivatives [1,[3][4][5][6]. Nevertheless, for these applications, curcumin presents some disadvantages, namely poor water solubility, poor bioavailability, and fast metabolic degradation [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A Computational Study of Structure and Reactivity of N-Substitued-4-Piperidones Curcumin Analogues and Their Radical Anions

2016

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In this work, a computational study of a series of N-substitued-4-piperidones curcumin analogues is presented. The molecular structure of the neutral molecules and their radical anions, as well as their reactivity, are investigated. N-substituents include methyl and benzyl groups, while substituents on the aromatic rings cover electron-donor and electron-acceptor groups. Substitutions at the nitrogen atom do not significantly affect the geometry and frontier molecular orbitals (FMO) energies of these molecules. On the other hand, substituents on the aromatic rings modify the distribution of FMO. In addition, they influence the capability of these molecules to attach an additional electron, which was studied through adiabatic (AEA) and vertical electron affinities (VEA), as well as vertical detachment energy (VDE). To study electrophilic properties of these structures, local reactivity indices, such as Fukui (f + ) and Parr (P + ) functions, were calculated, and show the influence of the aromatic rings substituents on the reactivity of α,β-unsaturated ketones towards nucleophilic attack. This study has potential implications for the design of curcumin analogues based on a 4-piperidone core with desired reactivity.

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“…The use of the mitochondrial uniporter inhibitor (RU-360) partially suppressed curcumin-induced apoptosis. Moreover, the use of SKF-96365, a store-operated Ca 2+ channel blocker, blocked the elevation of mitochondrial calcium, promoting a potentiation in curcumin-induced apoptosis [288]. …”

Section: Cellular Deathmentioning

confidence: 99%

Unraveling the Anticancer Effect of Curcumin and Resveratrol

et al. 2016

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Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.

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Curcumin induces apoptosis in a murine mammary gland adenocarcinoma cell line through the mitochondrial pathway

Cited by 30 publications

References 34 publications

Curcumin: the spicy modulator of breast carcinogenesis

Curcumin: the spicy modulator of breast carcinogenesis

A Computational Study of Structure and Reactivity of N-Substitued-4-Piperidones Curcumin Analogues and Their Radical Anions

Unraveling the Anticancer Effect of Curcumin and Resveratrol

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