Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells

Hua, Wen; Fu, Yong; Liao, Yi; Wen, Xin; Chen, Yangchao; Zeng, Yi Xin; Kung, Hsiang Fu; Xie, Dan

doi:10.1016/j.ejphar.2010.03.051

Cited by 103 publications

(74 citation statements)

References 24 publications

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“…Curcumin, a natural ingredient present in turmeric, also decrease breast cancer cell proliferation by modulating EZH2 levels and inducing G 1 arrest in MDA-MB-435 breast cancer cells. 127 Mitogen-activated protein kinase (MAPK) pathway was reported to be involved in the downregulation of EZH2, contributing to the curcumininduced anti-proliferative effect in breast cancer cells. A recent study demonstrated that (−)-epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, independently or in combination with DZNep, reduces EZH2 and other PcG proteins such as EED, SUZ12, Mel18 and Bmi-1 levels in skin cancer cells.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Multifaceted role of EZH2 in breast and prostate tumorigenesis

2013

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Section: Acknowledgmentsmentioning

confidence: 99%

Multifaceted role of EZH2 in breast and prostate tumorigenesis

2013

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“…In human breast cancers, overexpression of enhancer of zeste homolog 2 (EZH2) gene indicates poor prognosis; curcumin treatment of MDA-MB-435 breast cancer cells led to the downregulation of EZH2 expression in a dose-and time-dependent manner, which also correlated with decreased cell proliferation. Curcumin induces downregulation of EZH2 through activation of MAPK, c-Jun NH2-terminal kinase, ERK, and p38, leading to anti-proliferative effects (45).…”

Section: Curcuminmentioning

confidence: 99%

Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention

Thakur

Deb

Babcook

et al. 2013

AAPS J

141

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Abstract. In recent years, "nutri-epigenetics," which focuses on the influence of dietary agents on epigenetic mechanism(s), has emerged as an exciting novel area in epigenetics research. Targeting of aberrant epigenetic modifications has gained considerable attention in cancer chemoprevention research because, unlike genetic changes, epigenetic alterations are reversible and occur during early carcinogenesis. Aberrant epigenetic mechanisms, such as promoter DNA methylation, histone modifications, and miRNA-mediated post-transcriptional alterations, can silence critical tumor suppressor genes, such as transcription factors, cell cycle regulators, nuclear receptors, signal transducers, and apoptosis-inducing and DNA repair gene products, and ultimately contribute to carcinogenesis. In an effort to identify and develop anticancer agents which cause minimal harm to normal cells while effectively killing cancer cells, a number of naturally occurring phytochemicals in food and medicinal plants have been investigated. This review highlights the potential role of plant-derived phytochemicals in targeting epigenetic alterations that occur during carcinogenesis, by modulating the activity or expression of DNA methyltransferases, histone modifying enzymes, and miRNAs. We present in detail the epigenetic mode of action of various phytochemicals and discuss their potential as safe and clinically useful chemopreventive strategies.

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“…The stirring rate was 400 rpm and the temperature was 37 °C. At different intervals (1,2,4,8,10,12,18,24,36, and 48 h), the receptor samples were removed and replaced with fresh receptor medium. The receptor samples were then analyzed for the drug content by HPLC.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

“…It has a variety of biological activities and pharmacological actions, such as anti-inflammatory, anti-carcinogenic, and anti-virus properties, as well as promising clinical applications due to its low toxicity [1][2][3]. In recent years, curcumin has been shown to inhibit cell proliferation in a variety of human cancer-cell lines in vitro [4][5][6] and has been used both to prevent and treat various cancers in vivo [7,8]. However, its extremely low aqueous-solubility and rapid intestinal and hepatic metabolism, which result in poor systemic bioavailability, restrict its oral use [9].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics

et al. 2012

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This study aimed to investigate the in vitro skin permeation and in vivo antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated soybean phospholipids (HSPC) were selected for the preparation of different kinds of phospholipids composed of curcumin-loaded liposomes: C-SPC-L (curcumin-loaded SPC liposomes), C-EPC-L (curcumin-loaded EPC liposomes), and C-HSPC-L (curcumin-loaded HSPC liposomes). The physical properties of different lipsomes were investigated as follows: photon correlation spectroscopy revealed that the average particle sizes of the three types of curcumin-loaded liposomes were 82.37 ± 2.19 nm (C-SPC-L), 83.13 ± 4.89 nm (C-EPC-L), and 92.42 ± 4.56 nm (C-HSPC-L), respectively. The encapsulation efficiency values were found to be 82.32 ± 3.91%, 81.59 ± 2.38%, and 80.77 ± 4.12%, respectively. An in vitro skin penetration study indicated that C-SPC-L most significantly promoted drug permeation and deposition followed by C-EPC-L, C-HSPC-L, and curcumin solution. Moreover, C-SPC-L displayed the greatest ability of all loaded liposomes to inhibit the growth of B16BL6 melanoma cells. Therefore, the C-SPC-L were chosen for further pharmacodynamic evaluation. A significant effect on antimelanoma activity was observed with C-SPC-L, as compared to treatment with curcumin solution in vivo. These results suggest that C-SPC-L would be a promising transdermal carrier for curcumin in cancer treatment.

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Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells

Cited by 103 publications

References 24 publications

Multifaceted role of EZH2 in breast and prostate tumorigenesis

Multifaceted role of EZH2 in breast and prostate tumorigenesis

Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention

Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics

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