Curcumin inhibits colon cancer malignant progression and promotes T cell killing by regulating miR‐206 expression

Tong, Qin; Wu, Zhangqiang

doi:10.1002/ca.24057

Cited by 10 publications

(3 citation statements)

References 40 publications

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“…PD-L1 expression in tumor cells correlates with tumor immune evasion and poor clinical outcomes [ 56 ]. Accumulating evidence has shown the anti-tumor effects of suppressing PD-L1 expression in tumor cells [ 57 , 58 ]. In our study, SH003 effectively blocked the progression of melanoma by targeting the PD-L1 signaling pathway and promoting cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Mixture of Natural Products SH003 Exerts Anti-Melanoma Effects through the Modulation of PD-L1 in B16F10 Cells

Han

Park

et al. 2023

Nutrients

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Melanoma is the most invasive and lethal skin cancer. Recently, PD-1/PD-L1 pathway modulation has been applied to cancer therapy due to its remarkable clinical efficacy. SH003, a mixture of natural products derived from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, and formononetin (FMN), an active constituent of SH003, exhibit anti-cancer and anti-oxidant properties. However, few studies have reported on the anti-melanoma activities of SH003 and FMN. This work aimed to elucidate the anti-melanoma effects of SH003 and FMN through the PD-1/PD-L1 pathway, using B16F10 cells and CTLL-2 cells. Results showed that SH003 and FMN reduced melanin content and tyrosinase activity induced by α-MSH. Moreover, SH003 and FMN suppressed B16F10 growth and arrested cells at the G2/M phase. SH003 and FMN also led to cell apoptosis with increases in PARP and caspase-3 activation. The pro-apoptotic effects were further enhanced when combined with cisplatin. In addition, SH003 and FMN reversed the increased PD-L1 and STAT1 phosphorylation levels induced by cisplatin in the presence of IFN-γ. SH003 and FMN also enhanced the cytotoxicity of CTLL-2 cells against B16F10 cells. Therefore, the mixture of natural products SH003 demonstrates therapeutic potential in cancer treatment by exerting anti-melanoma effects through the PD-1/PD-L1 pathway.

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Section: Discussionmentioning

confidence: 99%

The Mixture of Natural Products SH003 Exerts Anti-Melanoma Effects through the Modulation of PD-L1 in B16F10 Cells

Han

Park

et al. 2023

Nutrients

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“…Curcumin , derived from the dried rhizome of turmeric, is rich in phenols, terpenoids, flavonoids, and other constituents. Specifically categorized as a diphenyl heptane within the phenolic group, curcumin treatment has been discovered to effectively impede the proliferation and promote the apoptosis of colon cancer cells ( 128 ). Notably, curcumin treatment elevates the expression of miR-206, which subsequently influences the functional behavior of colon cancer cells.…”

Section: New Findings Of Tcm Natural Products and Derivatives As Immu...mentioning

confidence: 99%

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Miao,

Liu,

et al. 2023

Front. Immunol.

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At present, cancer is the largest culprit that endangers human health. The current treatment options for cancer mainly include surgical resection, adjuvant radiotherapy and chemotherapy, but their therapeutic effects and long-term prognosis are unsatisfactory. Immunotherapy is an emerging therapy that has completely transformed the therapeutic landscape of advanced cancers, and has tried to occupy a place in the neoadjuvant therapy of resectable tumors. However, not all patients respond to immunotherapy due to the immunological and molecular features of the tumors. Traditional Chinese Medicine (TCM) provides a new perspective for cancer treatment and is considered to have the potential as promising anti-tumor drugs considering its immunoregulatory properties. This review concludes commonly used TCM monomers and compounds from the perspective of immune regulatory pathways, aiming to clearly introduce the basic mechanisms of TCM in boosting cancer immunotherapy and mechanisms of several common TCM. In addition, we also summarized closed and ongoing trials and presented prospects for future development. Due to the significant role of immunotherapy in the treatment of non-small cell lung cancer (NSCLC), TCM combined with immunotherapy should be emphasized in NSCLC.

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“…Studies have shown that Cur can reprogram the pro-tumor phenotype of cancer-associated fibroblasts ( 8 ) and inhibit the invasion and migration of carcinoma cells ( 9 ), effectively controlling carcinoma progression. Cur is thought to be a potent anti-tumor agent in colorectal cancer ( 10 ). A comprehensive understanding of the anti-tumor mechanism of Cur will provide a better reference for the clinical application of Cur.…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles isolated from curcumin-medium weakened RKO cell proliferation and migration

Xu,

Liu

2024

Transl Cancer Res

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Background Curcumin (Cur) is a natural phytochemical that is expected to become an indispensable drug for the treatment of colorectal cancer. A comprehensive understanding of the anti-tumor mechanism of Cur will provide a better reference for its clinical application. This study aimed to examine the effects of extracellular vesicles (EVs) isolated from Cur-medium on RKO colorectal cancer cell proliferation, apoptosis, and migration. Methods RKO cells were cultured in various concentrations of Cur-medium, and the EVs were isolated from the Cur-medium. The EVs were identified by transmission electron microscopy and western blotting. The effects of the EVs on RKO cell proliferation, apoptosis, and migration were analyzed, as was the expression of proliferating cell nuclear antigen (PCNA), Bax, vimentin, and E-cadherin. The expression of nuclear factor κB (NF-κB) p65 in the EVs was also detected. Results Our results showed that the EVs isolated from the Cur-medium weakened RKO cell proliferation and migration but had no effect on cell apoptosis. Cur suppressed the expression of NF-κB p65 in the EVs. Overall, this study revealed that Cur exerts anti-tumor effects by suppressing NF-κB p65 in EVs to weaken RKO cell proliferation and migration. Conclusions In conclusion, the packaging of Cur into EVs is expected to become an indispensable treatment of colorectal cancer in the future.

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Curcumin inhibits colon cancer malignant progression and promotes T cell killing by regulating miR‐206 expression

Cited by 10 publications

References 40 publications

The Mixture of Natural Products SH003 Exerts Anti-Melanoma Effects through the Modulation of PD-L1 in B16F10 Cells

The Mixture of Natural Products SH003 Exerts Anti-Melanoma Effects through the Modulation of PD-L1 in B16F10 Cells

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Extracellular vesicles isolated from curcumin-medium weakened RKO cell proliferation and migration

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