Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP PCG-1a nbsp  and pERK1 2

Hou, Kaijian; Chen, Yongru; Zhu, Dan; Chen, Genben; Chen, Fengwu; Xu, Ningning; Barakat, Khan; Zheng, Jiehong; Xie, Xi; Chen, Rongping

doi:10.2741/4887

Cited by 6 publications

(2 citation statements)

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“…MAPK1 protein has been reported to be overexpressed in cultured human dental pulp cells from decayed teeth [ 34 ]. Curcumin has been shown to inhibit MAPK1 phosphorylation in cultured pancreatic beta cells [ 35 ]. Therefore, curcumin could decrease caries inflammation through MAPK1.…”

Section: Discussionmentioning

confidence: 99%

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

Guzmán-Flores,

Pérez-Reyes,

Vázquez-Jiménez

et al. 2024

Dentistry Journal

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Background: Dental caries is a dynamic, multifactorial disease that destroys teeth and can affect anyone’s quality of life because it can cause tooth loss and make chewing difficult. Dental caries involves various factors, such as Streptococcus mutans and host factors. Currently, adjuvant therapies, such as curcumin, have emerged, but how they work has not been adequately described. Therefore, this work aims to identify the molecular mechanism of curcumin in caries and Streptococcus mutans. Methods: We obtained differentially expressed genes from a GEO dataset, and curcumin targets were obtained from other databases. The common targets were analyzed according to gene ontology enrichment, key genes were obtained, and binding to curcumin was verified by molecular docking. Results: Our analysis showed that curcumin presents 134 therapeutic targets in caries. According to the gene ontology analysis, these targets are mainly involved in apoptosis and inflammation. There are seven key proteins involved in the action of curcumin on caries: MAPK1, BCL2, KRAS, CXCL8, TGFB1, MMP9, and IL1B, all of which spontaneously bind curcumin. In addition, curcumin affects metabolic pathways related to lipid, purine, and pyrimidine metabolism in Streptococcus mutans. Conclusions: Curcumin affects both host carious processes and Streptococcus mutans.

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Section: Discussionmentioning

confidence: 99%

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

Guzmán-Flores,

Pérez-Reyes,

Vázquez-Jiménez

et al. 2024

Dentistry Journal

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“…In vitro studies have shown that CL increases insulin expression and secretion by activating the phosphatidylinositol-3-kinase/protein kinase B/glucose transporter 2 (PI3K/Akt/GLUT2) signaling pathway and upregulates insulin mRNA expression [ 73 ]. In mouse models, CL attenuated oxidative stress, dose-dependently reducing the apoptosis of pancreatic β-cells [ 74 ]. In hepatocytes and adipocytes, CL reduced glucose uptake by inhibiting the translocation of GLUT4 from the cytosol to the plasma membrane via the insulin receptor substance 1/PI3K/Akt signaling pathway [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of turmeric (Curcuma longa) supplementation on glucose metabolism in diabetes mellitus and metabolic syndrome: An umbrella review and updated meta-analysis

Pathomwichaiwat,

Jinatongthai,

Prommasut

et al. 2023

PLoS ONE

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Aims This study aims to comprehensively review the existing evidence and conduct analysis of updated randomized controlled trials (RCTs) of turmeric (Curcuma longa, CL) and its related bioactive compounds on glycemic and metabolic parameters in patients with type 2 diabetes (T2DM), prediabetes, and metabolic syndrome (MetS) together with a sub-group analysis of different CL preparation forms. Methods An umbrella review (UR) and updated systematic reviews and meta-analyses (SRMAs) were conducted to evaluate the effects of CL compared with a placebo/standard treatment in adult T2DM, prediabetes, and MetS. The MEDLINE, Embase, The Cochrane Central Register of Control Trials, and Scopus databases were searched from inception to September 2022. The primary efficacy outcomes were hemoglobin A1C (HbA1C) and fasting blood glucose (FBG). The corrected covered area (CCA) was used to assess overlap. Mean differences were pooled across individual RCTs using a random-effects model. Subgroup and sensitivity analyses were performed for various CL preparation forms. Results Fourteen SRMAs of 61 individual RCTs were included in the UR. The updated SRMA included 28 studies. The CCA was 11.54%, indicating high overlap across SRMAs. The updated SRMA revealed significant reduction in FBG and HbA1C with CL supplementation, obtaining a mean difference (95% confidence interval [CI]) of –8.129 (–12.175, –4.084) mg/dL and –0.134 (–0.304, –0.037) %, respectively. FBG and HbA1C levels decreased with all CL preparation forms as did other metabolic parameters levels. The results of the sensitivity and subgroup analyses were consistent with those of the main analysis. Conclusion CL supplementation can significantly reduce FBG and HbA1C levels and other metabolic parameters in T2DM and mitigate related conditions, including prediabetes and MetS. Trial registration PROSPERO (CRD42016042131).

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Curcumin and Intestinal Oxidative Stress of Pigs With Intrauterine Growth Retardation: A Review

et al. 2022

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Intrauterine growth restriction (IUGR) refers to the slow growth and development of a mammalian embryo/fetus or fetal organs during pregnancy, which is popular in swine production and causes considerable economic losses. Nutritional strategies have been reported to improve the health status and growth performance of IUGR piglets, among which dietary curcumin supplementation is an efficient alternative. Curcumin is a natural lipophilic polyphenol derived from the rhizome of Curcuma longa with many biological activities. It has been demonstrated that curcumin promotes intestinal development and alleviates intestinal oxidative damage. However, due to its low bioavailability caused by poor solubility, chemical instability, and rapid degradation, the application of curcumin in animal production is rare. In this manuscript, the structural-activity relationship to enhance the bioavailability, and the nutritional effects of curcumin on intestinal health from the aspect of protecting piglets from IUGR associated intestinal oxidative damage were summarized to provide new insight into the application of curcumin in animal production.

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Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP PCG-1a nbsp and pERK1 2

Cited by 6 publications

References 0 publications

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

Effects of turmeric (Curcuma longa) supplementation on glucose metabolism in diabetes mellitus and metabolic syndrome: An umbrella review and updated meta-analysis

Curcumin and Intestinal Oxidative Stress of Pigs With Intrauterine Growth Retardation: A Review

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