Curcumin inhibits iron-dependent lipid peroxidation

Sreejayan,; Rao, M. N. A.

doi:10.1016/0378-5173(93)90079-u

Cited by 56 publications

(21 citation statements)

References 23 publications

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“…However it has been proved that copper complexation enhanced the activities in all the cases. Earlier studies have shown that curcumin is an inhibitor of lipid peroxidation, 18 which promotes anticancer properties of the compound. It has also been reported that curcumin-gold complex is an effective antiarthritic agent.…”

Section: Effect Of Compounds On Solid Tumour Developmentmentioning

confidence: 99%

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

John¹,

Krishnankutty²

2006

Appl. Organometal. Chem.

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Four new curcuminoid analogues, 1,7-bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, 1a; 1,7-di(2-furyl)-1,6-heptadiene-3,5-dione, 1b; 1,7-di(2-naphthyl)-1,6-heptadiene-3,5-dione, 1c; 1,7-bis(2-chlorophenyl)-1,6-heptadiene-3,5-dione, 1d; and their copper(II) complexes of ML 2 stoichiometry were synthesized and characterized by UV, IR, 1 H NMR, ESR and mass spectral data. The compounds were investigated for their possible cytotoxic and antitumour activities. It was found that copper chelates are remarkably active compared with free curcuminoid analogues. All the compounds were found to be cytotoxic towards Ehrlich ascites carcinoma cells and cultured L929 (lung fibroblast cells). In the case of culture studies, concentrations needed for 50% cell death were around 5 µg/ml for copper complexes and 10 µg/ml for curcuminoid analogues. Copper complex of 1a with hydroxyl group in the phenyl ring was found to be most active towards L929cells (1 µg/ml produced 43.3 ± 1.3% cell death). Compound 1b, which possesses a furyl ring system, was found to show least activity towards increase in life span of tumour-bearing mice (increase in life span 39.31%). Copper chelates of all curcuminoid analogues showed a significant reduction (p < 0.001) of solid tumour volume in mice.

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Section: Effect Of Compounds On Solid Tumour Developmentmentioning

confidence: 99%

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

John¹,

Krishnankutty²

2006

Appl. Organometal. Chem.

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“…Studies have shown that ingestion of turmeric reduced the levels of lipid peroxides and resulted in higher activities of superoxide dismutase, catalase and glutathione peroxidase in liver homogenate (26,27). Studies have shown that curcumin is a potent inhibitor of lipid peroxidation catalysed by iron and its chelates in rat brain homogenate and rat liver microsomes (28) Curcuminoids are potent inhibitors of experimentally induced lipid peroxidation as that of D-tocopherol (17). Curcumin has been found to be more potent than D-tocopherol as an antioxidant in the inhibition of lipid peroxidation of rat liver microsomes (14).…”

Section: Discussionmentioning

confidence: 99%

In vitro inhibition of lipid peroxidation in fish by turmeric (Curcuma longa)

D'Souza

Prabhu

2006

Indian J Clin Biochem

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“…In the last 20 years, a constantly increasing number of publications have shown that, in vitro, curcumin displays notable effects, not only as an anti-inflammatory compound [15][16][17][18][19][20] but also as a potent antioxidant [19][20][21][22][23][24][25][26][27][28][29], chemopreventive [30][31][32][33][34][35][36][37] and chemotherapeutic [38][39][40][41] agent. Moreover, curcumin can inhibit the metabolic action of aflatoxin B 1 [42], of aminopeptidase N [43], of lipoxygenase [44], of cycloxygenase [45], of ornithine decarboxylase [37] and of the efflux transporters MRP1 and MRP2 [46].…”

Section: Curcumin and Its Derivatives As Photosensitizersmentioning

confidence: 99%