Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells

Ghasemi, Faezeh; Shafiee, Mojtaba; Banikazemi, Zarrin; Pourhanifeh, Mohammad Hossein; Khanbabaei, Hashem; Shamshirian, Amir; Moghadam, Shirin Amiri; ArefNezhad, Reza; Sahebkar, Amirhossein; Avan, Amir; Mirzaei, Hamed

doi:10.1016/j.prp.2019.152556

Cited by 221 publications

(108 citation statements)

References 64 publications

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“…As a result, that mediation of IL-6 and soluble IL-6 receptor secretion by the miR-145-ADAM17 pathway has been revealed that could played a role in maintaining the CSC characteristics in a paracrine way. Curcumin is a natural compounds that could be used in the treatment of different diseases such as cancer [168][169][170][171][172][173][174][175]. The curcumin delivery attenuated the tumor expansion in vivo by enhancing the miR-145 promoter activities [167].…”

Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.

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Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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“…Cervical cancer is known as the fourth cancer among women and the eighth common cancer worldwide [1,2]. Cervical cancer is a result of being infected by some types of human papillomavirus or HPV, which are effective on the mucosa [3,4].…”

Section: Introductionmentioning

confidence: 99%

Functional activities of beta-glucans in the prevention or treatment of cervical cancer

et al. 2020

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Cervical cancer is the fourth-ranked cancer in the world and is associated with a large number of deaths annually. Chemotherapy and radiotherapy are known as the common therapeutic approaches in the treatment of cervical cancer, but because of their side effects and toxicity, researchers are trying to discovery alternative therapies. Betaglucans, a group of glucose polymers that are derived from the cell wall of fungi, bacteria, and etc. it has been showed that beta-glucans have some anti-cancer properties which due to their impacts on adaptive and innate immunity. Along to these impacts, these molecules could be used as drug carriers. In this regard, the application of beta-glucans is a promising therapeutic option for the cancer prevention and treatment especially for cervical cancer. Herein, we have summarized the therapeutic potential of beta-glucans alone or as adjuvant therapy in the treatment of cervical cancer. Moreover, we highlighted beta-glucans as drug carriers for preventive and therapeutic purposes.

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“…1,2 Although CC at the early stage could be cured via surgery, most patients are diagnosed at advanced or metastatic stages. 3,4 Treatment by surgery, chemotherapy and radiotherapy achieves unsatisfactory outcomes in these advanced patients. And the five-year survival rate of CC patients remains very low.…”

Section: Introductionmentioning

confidence: 99%

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Liu

Wen

2020

CMAR

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Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells

Cited by 221 publications

References 64 publications

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

Functional activities of beta-glucans in the prevention or treatment of cervical cancer

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

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