Curcumin inhibits the invasion and migration of pancreatic cancer cells by upregulating TFPI-2 to regulate ERK- and JNK-mediated epithelial–mesenchymal transition

Zhai, Lu-Lu; Li, Wei-Bo; Chen, Long-Jiang; Wang, Wei; Ju, Tong-Fa; Yin, Da-Long

doi:10.1007/s00394-023-03296-5

Eur J Nutr

2023

DOI: 10.1007/s00394-023-03296-5

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Curcumin inhibits the invasion and migration of pancreatic cancer cells by upregulating TFPI-2 to regulate ERK- and JNK-mediated epithelial–mesenchymal transition

Lu-Lu Zhai,

Wei-Bo Li,

Long-Jiang Chen

et al.

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2024

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Cited by 6 publications

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Curcuma Longa: Nutraceutical Use and Association With Nanotechnology

Corrêa Carvalho,

Marena,

Gaspar Gonçalves Fernandes

et al. 2024

Adv Healthcare Materials

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Curcumin is a natural product found in the rhizome of Curcuma longa (L) and other Curcuma spp. As a lipophilic molecule, it has greater affinity for polar, non‐polar, alkaline or extremely acidic organic solvents. Several studies indicate that curcumin has several benefits for human health, for example, against degenerative diseases, cancer and infectious diseases. To obtain a quality product with nutraceutical properties, it is necessary to know its physicochemical characteristics and preserve it from cultivation until ingestion by the human. However, its low solubility leads to low absorption, in this context, nanotechnological systems can contribute to increase curcumin bioavailability. This review aims to highlight important issues in all stages that curcumin goes through: from aspects related to its extraction, to its association with nanotechnology. Although curcumin extraction process is already well established, it is possible to observe that more and more research focused on increasing yield and being more environmentally friendly. Furthermore, curcumin's low absorption is notable due to its physicochemical characteristics, mainly due to its low aqueous solubility. However, its association with nanotechnology has shown to be promising and an increasingly growing trend, since the use of this “Indian solid gold” is the hope of many patients.This article is protected by copyright. All rights reserved

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Curcuma Longa: Nutraceutical Use and Association With Nanotechnology

Corrêa Carvalho,

Marena,

Gaspar Gonçalves Fernandes

et al. 2024

Adv Healthcare Materials

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show abstract

Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

Saadh,

Mustafa,

Malathi

et al. 2024

Med Oncol

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A focus on c-Jun-N-terminal kinase signaling in sepsis-associated multiple organ dysfunction: Mechanisms and therapeutic strategies

Gagnani,

Srivastava,

Suri

et al. 2024

International Immunopharmacology

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Curcumin inhibits the invasion and migration of pancreatic cancer cells by upregulating TFPI-2 to regulate ERK- and JNK-mediated epithelial–mesenchymal transition

Cited by 6 publications

References 59 publications

Curcuma Longa: Nutraceutical Use and Association With Nanotechnology

Curcuma Longa: Nutraceutical Use and Association With Nanotechnology

Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

A focus on c-Jun-N-terminal kinase signaling in sepsis-associated multiple organ dysfunction: Mechanisms and therapeutic strategies

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