Curcumin loaded gold nanoparticles–chitosan/sodium alginate nanocomposite for nanotheranostic applications

Shanmugam, Balu Kolathupalayam; Rajendran, Nidhusha; Karthik, A.; Rangaraj, Suriyaprabha; Subramani, Karthik; Surendhiran, S.; Nayagam, Lenin; Aicher, Wilhelm K.; Rajendran, V.

doi:10.1080/09205063.2022.2151819

Cited by 7 publications

(13 citation statements)

References 34 publications

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“…21 Moreover, AZA and AZT scaffolds have less swelling because the presence of alumina-zirconia nanoparticles decreases water absorption, which is favorable for the mechanical strength of scaffolds. 24 The swelling ratio of the scaffolds matches with contact angle measurements.…”

Section: Characterization Of Csc and Csaz Scaffoldsmentioning

confidence: 52%

“…In addition, during the biomineralization study, ion release from SBF to samples is analyzed through pH and conductivity measurement and illustrated in Figure 5(iii‐vi). Changes in pH and conductivity, especially in the 14th to 15th days of incubation followed by decreasing, lead to HAp layer formation on the surfaces, which are investigated using FTIR 24 …”

Section: Resultsmentioning

confidence: 99%

“…Changes in pH and conductivity, especially in the 14th to 15th days of incubation followed by decreasing, lead to HAp layer formation on the surfaces, which are investigated using FTIR. 24 Swelling properties of the CSC, AZA, and AZT scaffolds are calculated using PBS for 5 days. The everyday weight of the scaffolds observed, and their values are shown in Figure 4(iii).…”

Section: Characterization Of Csc and Csaz Scaffoldsmentioning

confidence: 99%

“…29 The zone of inhibition values produced by (100 mg/mL) of CSC, AZA-1,2,3, and AZT-1,2,3 scaffolds against S. aureus is 9. along with nanoparticles attached to the bacterial surface. 24 All the scaffolds produce a broader zone of inhibition against S. aureus than E. coli due to the plasmolytic activity of scaffolds involved in separating cytoplasm from their cell membrane. 12 S. aureus is highly susceptible toward scaffolds due to its thin cell wall structure than E. coli.…”

Section: Characterization Of Csc and Csaz Scaffoldsmentioning

confidence: 99%

“…Also, P O vibrated at 1050 cm À1 . Above mentioned peaks, reveal HAp layer formation on the surface of CSC, AZA, and AZT scaffolds 8,[24][25][26]. In addition, during the biomineralization study, ion release from SBF to samples is analyzed through pH and…”

mentioning

confidence: 99%

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A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications

Shanmugam,

Arumugam,

Srinivasan

et al. 2023

Polymers for Advanced Techs

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Presently, alumina-zirconia nanoparticles are prominently used in biomedical applications because of their valuable properties and augmented biological interactions. Amorphous (AZA) and tetragonal phase (AZT) nanoparticles are synthesized by spray pyrolysis. Three concentrations (10/15/20 mg) of synthesized alumina-zirconia nanoparticles were mixed separately with 4 wt% of chitosan-sodium alginate composite and developed as scaffolds using solvent casting. The physico-chemical and in vitro biological properties of the prepared samples are evaluated using appropriate techniques. The physico-chemical characteristics of AZT (tetragonal phase) nanoparticles and their scaffolds enhances in vitro biocompatibility, improve antibacterial activity against S. aureus and E. coli and also possess better in vitro cytotoxicity against human osteosarcoma (MG-63) cells compare than amorphous nanoparticles (AZA) and their scaffolds. From the analysis, AZT nanoparticles and AZT scaffolds are fit for biomedical applications, including tissue engineering and nano theranostics.

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Section: Characterization Of Csc and Csaz Scaffoldsmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Characterization Of Csc and Csaz Scaffoldsmentioning

confidence: 99%

Section: Characterization Of Csc and Csaz Scaffoldsmentioning

confidence: 99%

mentioning

confidence: 99%

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A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications

Shanmugam,

Arumugam,

Srinivasan

et al. 2023

Polymers for Advanced Techs

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In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co₃O₄ nanoparticles loaded biomimetic scaffold for preclinical analysis

Savitha,

Surendhiran,

Balu

et al. 2023

Polymers for Advanced Techs

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The work aims for biomimetic fabrication of Moringa oleifera seed (MOS) extract‐mediated cobalt oxide nanoparticles (Co3O4 NPs) with chitosan‐sodium alginate scaffolds by solvent casting. Distinct concentrations of green synthesized Co3O4 nanoparticles were combined to fabricate scaffolds. XRD analysis revealed the cubic structure with an average crystallite size of 18.83 nm. Smaller particle size, spherical morphology, and the presence of organic MOS extract had a substantial impact on the physio‐chemical properties of Co3O4 NPs. In‐vitro bioactivity Co3O4 NPs and nanoparticles anchored scaffolds were determined using simulated body fluid (SBF) through HAP formation. The scaffolds' swelling, protein absorption behavior and bio‐electrochemical analysis were evaluated under PBS. The antibacterial activity of Co3O4 NPs/scaffolds was more effective against Gram‐positive bacterial strains than Gram‐negative ones due to the increased production of ROS. In‐vitro cytotoxicity of the synthesized Co3O4 NPs and scaffolds was tested against the MCF‐7 cell line using an MTT assay. These studies demonstrate that the Co3O4 NPs/scaffolds have excellent physico‐chemical characteristics that increase in‐vitro biocompatibility. Furthermore, impedance and LSV studies showed that biomimetic CSA 200 electrolytes extend host tissue's regenerative compatibility. Also, the anticancer and antibacterial properties of biomimetic scaffold enabled Co3O4 nanoparticles to retain their required biomaterial characteristics for tissue engineering applications.

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Curcumin nanopreparations: recent advance in preparation and application

Liu,

Yin,

Tian

et al. 2024

Biomed. Mater.

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Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders and a variety of bioactivities, which is widely used in the field of food and medicine. However, the drawbacks of curcumin such as poor aqueous solubility and stability have limited the practical application of curcumin. To overcome these defects and enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein nanoparticles, solid lipid nanoparticles, metal nanoparticles, etc) have been extensively employed for curcumin encapsulation and delivery. Despite the rapid development of curcumin nanoformulations, there is a lack of comprehensive reviews on their preparation and properties. This review provides an overview of the construction of curcumin nano-delivery systems, mechanisms of action, nanocarrier preparation methods and the applications of curcumin nanocarriers in the food and pharmaceutical fields to provide a theoretical basis and technological support for the efficient bio-utilization, product development and early clinical application of curcumin.

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Curcumin loaded gold nanoparticles–chitosan/sodium alginate nanocomposite for nanotheranostic applications

Cited by 7 publications

References 34 publications

A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications

A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications

In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co₃O₄ nanoparticles loaded biomimetic scaffold for preclinical analysis

Curcumin nanopreparations: recent advance in preparation and application

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Curcumin loaded gold nanoparticles–chitosan/sodium alginate nanocomposite for nanotheranostic applications

Cited by 7 publications

References 34 publications

A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications

A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications

In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co3O4 nanoparticles loaded biomimetic scaffold for preclinical analysis

Curcumin nanopreparations: recent advance in preparation and application

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Product

Resources

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In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co₃O₄ nanoparticles loaded biomimetic scaffold for preclinical analysis