Curcumin-loaded multifunctional chitosan gold nanoparticles: An enhanced PDT/PTT dual-modal phototherapeutic and pH-responsive antimicrobial agent

Zhang, Ying; Li, Peiyuan; Su, Rixiang; Wen, Fangzhou; Jia, Zhen; Lv, Yingbin; Cai, Jinyun; Su, Wei

doi:10.1016/j.pdpdt.2022.103011

Cited by 28 publications

(7 citation statements)

References 62 publications

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“…Encouraged by the excellent biosafety and fine in vitro bactericidal performance of BG-SNP, the in vivo therapeutic efficacy of BG-SNP + laser in combating wound infection was further evaluated using trauma models with back wound inoculation of S. aureus . − The animal experiments were conducted strictly following the ethical guidelines of Weifang Medical University. The photographs of wounds during the treatment from days 0–9 are presented in Figure g.…”

Section: Resultsmentioning

confidence: 99%

Nanoporous BODIPY-Based Cationic Porous Organic Polymer Composites as Photocontrolled NO-Releasing Platforms for Wound Healing and Antimicrobial Applications

Wang,

Zhang,

Wang

et al. 2023

ACS Appl. Nano Mater.

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Here, an intelligent theranostic therapeutic platform based on a nanoporous ionic porous organic polymer (POP) hybrid (BG-SNP) endowed with photodriven nitric oxide (NO) release capacity was facilely fabricated as a four-mode synergistic antimicrobial agent. The BG-SNP nanoporous composite incorporated the motifs of guanidinium, BODIPY, and sodium nitroprusside (SNP) and, concurrently, could realize the combinational photothermal, photodynamic, cationic, and NO gas antibacterial therapy. This specific hybrid is constructed by in situ ion exchange, in which the negatively charged nitroprusside anion was bonded with the positively charged POP, forming a composite with controllable carbon monoxide generation behavior. Both the release amount and speed are highly controlled in response to photoirradiation. Upon laser irradiation (638 nm, 1.0 W cm–2) for 10 min, a BG-SNP nanoporous composite (250 μg mL–1) could rapidly generate massive quantities of NO, exerting a multimode synergistic antibacterial effect with bacteria killing >99% toward both the Staphylococcus aureus and Escherichia coli. Meanwhile, BG-SNP featured good biosafety according to blood and cell compatibility experiments. In vivo open-wound-healing assay revealed that the BG-SNP nanoporous composite also featured enhanced antibacterial and antiinflammatory capabilities in the infected wounds, thereby prominently accelerating the regeneration of skin tissue and closure of wounds. This unique “all-in-one” POP composite provides a safe but reliable multimode synergistic antibacterial strategy for the rapid repair of infected wounds.

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Section: Resultsmentioning

confidence: 99%

Nanoporous BODIPY-Based Cationic Porous Organic Polymer Composites as Photocontrolled NO-Releasing Platforms for Wound Healing and Antimicrobial Applications

Wang,

Zhang,

Wang

et al. 2023

ACS Appl. Nano Mater.

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“…CH was added to improve the dispersibility of curcumin in an aqueous solution, while AuNPs were used to enhance the electrostatic binding ability of the carrier to the bacterial cell membrane. They developed a polysaccharide-AuNPs antibacterial platform with electrostatic-targeting photodynamic and photothermal antibacterial properties [ 155 ]. Shaimaa et al [ 156 ] developed a pH-responsive nanocomposite hydrogel by synthesizing chitosan-grafted acrylamide monomers and incorporating gold nanoparticles.…”

Section: Drug Release From Polysaccharide-aunpsmentioning

confidence: 99%

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

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Clinical drug administration aims to deliver drugs efficiently and safely to target tissues, organs, and cells, with the objective of enabling their therapeutic effects. Currently, the main approach to enhance a drug’s effectiveness is ensuring its efficient delivery to the intended site. Due to the fact that there are still various drawbacks of traditional drug delivery methods, such as high toxicity and side effects, insufficient drug specificity, poor targeting, and poor pharmacokinetic performance, nanocarriers have emerged as a promising alternative. Nanocarriers possess significant advantages in drug delivery due to their size tunability and surface modifiability. Moreover, nano-drug delivery systems have demonstrated strong potential in terms of prolonging drug circulation time, improving bioavailability, increasing drug retention at the tumor site, decreasing drug resistance, as well as reducing the undesirable side effects of anticancer drugs. Numerous studies have focused on utilizing polysaccharides as nanodelivery carriers, developing delivery systems based on polysaccharides, or exploiting polysaccharides as tumor-targeting ligands to enhance the precision of nanoparticle delivery. These types of investigations have become commonplace in the academic literature. This review aims to elucidate the preparation methods and principles of polysaccharide gold nanocarriers. It also provides an overview of the factors that affect the loading of polysaccharide gold nanocarriers with different kinds of drugs. Additionally, it outlines the strategies employed by polysaccharide gold nanocarriers to improve the delivery efficiency of various drugs. The objective is to provide a reference for further development of research on polysaccharide gold nanodelivery systems.

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“…Moreover, aluminum phthalocyanine chloride was encapsulated in chitosan NPs to inactivate multispecies cariogenic biofilms [ 257 ]. Chitosan-gold NPs with curcumin conjugates were prepared to enhance curcumin's dispersibility and stability and provide a pH-responsive behavior that allows a controlled antibacterial effect against gram-positive and -negative species [ 258 ].…”

Section: Smart Dental Materials For Antimicrobial and Antibiofilm The...mentioning

confidence: 99%

Smart dental materials for antimicrobial applications

Montoya

Roldán

et al. 2023

Bioactive Materials

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Curcumin-loaded multifunctional chitosan gold nanoparticles: An enhanced PDT/PTT dual-modal phototherapeutic and pH-responsive antimicrobial agent

Cited by 28 publications

References 62 publications

Nanoporous BODIPY-Based Cationic Porous Organic Polymer Composites as Photocontrolled NO-Releasing Platforms for Wound Healing and Antimicrobial Applications

Nanoporous BODIPY-Based Cationic Porous Organic Polymer Composites as Photocontrolled NO-Releasing Platforms for Wound Healing and Antimicrobial Applications

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Smart dental materials for antimicrobial applications

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