Curcumin Loaded Nano Cubosomal Hydrogel: Preparation, In Vitro Characterization and Antibacterial Activity

Archana, A.; Sri, K. Vijaya; Madhuri, M.; Kumar, Ajay; Reddy, M. Rajavardhan

doi:10.7598/cst2015.913

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Specifically, the cocoa gel demonstrated antibacterial activity against P. fluorescens , B. licheniformis , and M. leuteus , and antifungal activity against R. oryzae , Trichoderma, and A. niger . Archana et al [ 46 ] prepared a hydrogel containing curcumin-loaded cubosomal to enhance curcumin activity in topical drug delivery. The morphological study of the curcumin-loaded cubosomes shows a particle size of 75.2 nm with a zeta potential of −24 mV.…”

Section: Nanocarriers In Their Effective Delivery Against Topical Inf...mentioning

confidence: 99%

Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders

Dwivedi,

Mandal,

Afzal

et al. 2023

Gels

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Flavonoids are hydroxylated phenolic substances in vegetables, fruits, flowers, seeds, wine, tea, nuts, propolis, and honey. They belong to a versatile category of natural polyphenolic compounds. Their biological function depends on various factors such as their chemical structure, degree of hydroxylation, degree of polymerization conjugation, and substitutions. Flavonoids have gained considerable attention among researchers, as they show a wide range of pharmacological activities, including coronary heart disease prevention, antioxidative, hepatoprotective, anti-inflammatory, free-radical scavenging, anticancer, and anti-atherosclerotic activities. Plants synthesize flavonoid compounds in response to pathogen attacks, and these compounds exhibit potent antimicrobial (antibacterial, antifungal, and antiviral) activity against a wide range of pathogenic microorganisms. However, certain antibacterial flavonoids have the ability to selectively target the cell wall of bacteria and inhibit virulence factors, including biofilm formation. Moreover, some flavonoids are known to reverse antibiotic resistance and enhance the efficacy of existing antibiotic drugs. However, due to their poor solubility in water, flavonoids have limited oral bioavailability. They are quickly metabolized in the gastrointestinal region, which limits their ability to prevent and treat various disorders. The integration of flavonoids into nanomedicine constitutes a viable strategy for achieving efficient cutaneous delivery owing to their favorable encapsulation capacity and diminished toxicity. The utilization of nanoparticles or nanoformulations facilitates drug delivery by targeting the drug to the specific site of action and exhibits excellent physicochemical stability.

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Section: Nanocarriers In Their Effective Delivery Against Topical Inf...mentioning

confidence: 99%

Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders

Dwivedi,

Mandal,

Afzal

et al. 2023

Gels

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“…The carriers also stabilize the bioactive elements and provide a protective barrier, thus preventing them from degradation. A few examples of carriers used in the encapsulation of bioactive elements, mainly antibacterial agents, include (i) liposomes − which are spherical vesicles containing at least one lipid bilayer formed from phospholipids, (ii) polymeric micelles − which are colloidal particles formed due to the aggregation of surfactant phospholipid molecules in liquid, and (iii) carbon-based materials such as carbon nanotubes, , carbon nanodots, , cubosomes, , and niosomes . The use of such carrier systems allows for high bioactive element loading capacity.…”

Section: Encapsulation and Release Of Bioactive Elementsmentioning

confidence: 99%

Multifunctional Composite Hydrogels for Bacterial Capture, Growth/Elimination, and Sensing Applications

Dsouza

Constantinidou

Arvanitis

et al. 2022

ACS Appl. Mater. Interfaces

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Hydrogels are cross-linked networks of hydrophilic polymer chains with a three-dimensional structure. Owing to their unique features, the application of hydrogels for bacterial/antibacterial studies and bacterial infection management has grown in importance in recent years. This trend is likely to continue due to the rise in bacterial infections and antimicrobial resistance. By exploiting their physicochemical characteristics and inherent nature, hydrogels have been developed to achieve bacterial capture and detection, bacterial growth or elimination, antibiotic delivery, or bacterial sensing. Traditionally, the development of hydrogels for bacterial/antibacterial studies has focused on achieving a single function such as antibiotic delivery, antibacterial activity, bacterial growth, or bacterial detection. However, recent studies demonstrate the fabrication of multifunctional hydrogels, where a single hydrogel is capable of performing more than one bacterial/antibacterial function, or composite hydrogels consisting of a number of single functionalized hydrogels, which exhibit bacterial/antibacterial function synergistically. In this review, we first highlight the hydrogel features critical for bacterial studies and infection management. Then, we specifically address unique hydrogel properties, their surface/network functionalization, and their mode of action for bacterial capture, adhesion/growth, antibacterial activity, and bacterial sensing, respectively. Finally, we provide insights into different strategies for developing multifunctional hydrogels and how such systems can help tackle, manage, and understand bacterial infections and antimicrobial resistance. We also note that the strategies highlighted in this review can be adapted to other cell types and are therefore likely to find applications beyond the field of microbiology.

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“…Rotating paddle dissolution apparatus type II was used to measure the in vitro drug release from all prepared formulas. The sealed dialysis bag containing nanocubosomal gel formulas (equivalent to 60 mg erythromycin) was immersed in 250 mL [16] phosphate buffered (pH 7.4 dissolution media) [17] with a rotating speed of 50 rpm. The temperature of the medium was maintained at 37±0.5°C.…”

Section: In Vitro Release Of the Drug From The Prepared Nanocubosomal...mentioning

confidence: 99%

In vitro Evaluation of the Effect of Using Different Gelling agents on the Release of Erythromycin from a Nanocubosomal gel

Al-Sakini

Maraie

2019

AJPS

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Preparation of a topical gel for erythromycin using optimized nano-sized cubosome dispersion, which is changed into a gel to get nanocubosomal gel using different gelling agents. The optimum nanocubosomal dispersion containing 4.4% glyceryl mono oleate (GMO) (as an oil phase) and 0.6% poloxamer 407 (as an emulsifying agent) was converted into a gel using different gelling agents including carbopol 974, carbopol 940, carbopol 934 and hydroxyl propyl methylcellulose (HPMC) at different ratios of (1:1 and 1:2). Each prepared gel was then evaluated in vitro to determine the homogenisity, consistency, spreadability, viscosity and drug release. The selected formula (FG6) showed best homogenisity, consistency and spreadability as well as it produced initial burst release of 60.3% (within 1 hour) followed by prolonged release of 96.3% continued for 4 hours. In addition, the optimum gel formula (FG6) has shown remarkable antibacterial activity, which was significantly higher than the marketed gel (ERYTHROMYCIN GEL ® 2%) against four different strains of bacteria (Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa).

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Curcumin Loaded Nano Cubosomal Hydrogel: Preparation, In Vitro Characterization and Antibacterial Activity

Cited by 6 publications

References 8 publications

Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders

Emergence of Nano-Based Formulations for Effective Delivery of Flavonoids against Topical Infectious Disorders

Multifunctional Composite Hydrogels for Bacterial Capture, Growth/Elimination, and Sensing Applications

In vitro Evaluation of the Effect of Using Different Gelling agents on the Release of Erythromycin from a Nanocubosomal gel

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