Curcumin-loaded nano-emulsion prepared by high pressure homogenization: impact of emulsifiers on physicochemical stability and in vitro digestion

Abstract

Curcumin possesses various pharmacological properties such as antioxidation, anticancer, and anti-inflammatory, but performs unexpected physicochemical stability and bioavailability when directly incorporate it into food or medicine. In this work, we fabricated a nano-emulsion system for the delivery and protection of curcumin. A precise and theoretically understandable fabrication procedure of curcumin-loaded nano-emulsion was proposed via systematically evaluating the effect of oil type (medium-chain triglyceride oil (MCT) and canola oil), emulsifier type (Tween-80 and lecithin), and surfactant-to-oil ratios (SOR) on the physiochemical properties and stabilities. In terms of oil phase, nano-emulsion fabricated by using MCT exhibited the highest curcumin loading capacity, smallest particle size and best storage stability. Meanwhile, Tween-80 and higher SOR were suggested to prepare monodisperse uniform, physicochemical stable and high loading nano-emulsion. In vitro digestion study indicated that most of curcumin encapsulated within nano-emulsions were released in small intestine, and the increase of particle size of the emulsions could be caused by bile salts displacing some surfactant from lipid surface. This work will finally contribute to the optimization of the curcumin nano-emulsion with better physiochemical characteristics and stability in food and beverage products.

Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review

“…NEs are homogeneous dispersion systems with particle sizes of 1 to 100 nm formed by water, oil, surfactants, and co-surfactants, which have also been designed to improve Cur performance. Chen et al [ 54 ] achieved controllable physicochemical properties and stability of Cur-loaded NEs by adjusting the oil type (medium chain triglyceride oil and canola oil), emulsifier type (Tween-80 and lecithin), and surfactant/oil ratio. Li et al [ 55 ] prepared chitosan-coated Cur-loaded NEs with 95% encapsulation efficiency, and the functionalization of chitosan effectively inhibited the degradation of Cur by heat and ultraviolet irradiation and improved the stability of Cur-loaded NEs.…”