Curcumin-loaded nanocapsules: Influence of surface characteristics on technological parameters and potential antimalarial activity

Santos, Raquel Rocha; Nakama, Kelly Ayumi; Pacheco, Camila Oliveira; Gomes, Marcelo Gomes de; Souza, Jaqueline F. de; Pinto, Ana Claudia de Souza; Oliveira, Fernanda Alice de; Fonseca, Amanda Luisa da; Varotti, Fernando de Pilla; Fajardo, André R.; Haas, Sandra Elisa

doi:10.1016/j.msec.2020.111356

Cited by 25 publications

(15 citation statements)

References 60 publications

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“…It can be seen that FTIR spectra of original curcumin and curcumin nanoparticles did not show significant differences. Infrared spectrum of curcumin showed its signature peaks at 3508 cm −1 (phenolic O-H stretching vibration), 1628 cm −1 (aromatic moiety C=C stretching), 1597 cm −1 (benzene ring stretching vibrations), 1509 cm −1 (C=O and C=C vibrations), 1428 cm −1 (olefinic C-H bending vibrations), 1278 cm −1 (aromatic C-O stretching vibrations), 1024 cm −1 (C-O-C stretching vibrations) [13]. [14][15][16]: (i) a broad medium intensity band at 3340 cm -1 was assigned to the hydroxyl group in the main structure, (ii) a sharp, intense band at 1735 cm -1 and another band at 1100 cm -1 corresponds to the C-O stretching vibrations in the acetate group, (iii) bands at 2940 and 2910 cm -1 attributed for the aliphatic backbone C-H stretching vibrations and (iv) the band at 1335 cm -1 has been assigned to the combination frequencies of (CH•OH).…”

Section: Ft-ir Optical Absorption Spectra Of Studied Materialsmentioning

confidence: 99%

Structural and optical characteristics of poly(vinyl alcohol)/carboxymethyl cellulose/ curcumin nanocomposites

Ahmed¹,

Aboelkhair²,

Abdelghany³

2022

Bull. Chem. Soc. Eth.

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ABSTRACT. Curcumin nanoparticles (CurNP’s) were successfully synthesized, characterized, and used as a cross-linking dopant of polyvinyl alcohol/ sodium carboxymethyl cellulose (PVA/CMC) semi-natural polymer blend. Synthesized nanocomposite films of (PVA/CMC/CurNP’s) were characterized using Fourier transforms infrared FTIR spectroscopy and tested for their resistance of different bacterial grams. Obtained data shows that studied PVA polymerized and cross-linked with CMC as a result for hydrogen bonding between the carboxylic groups and with the non-substituted hydroxyl groups of the cellulose molecule. The optical energy gap was found to be sensitive for the CurNP’s doping level, and the indirect transition was dominant in the studied samples. The addition of CurNP’s appears to increase the activity index of all samples against both gram-negative and positive bacteria, and their activity increases with increasing dopant level until a specific optimal concentration. KEY WORDS: Curcumin nanoparticles, Semi-natural polymer blend, Antibacterial, FTIR, Optical energy gap Bull. Chem. Soc. Ethiop. 2021, 35(3), 615-624. DOI: https://dx.doi.org/10.4314/bcse.v35i3.12

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Section: Ft-ir Optical Absorption Spectra Of Studied Materialsmentioning

confidence: 99%

Structural and optical characteristics of poly(vinyl alcohol)/carboxymethyl cellulose/ curcumin nanocomposites

Ahmed¹,

Aboelkhair²,

Abdelghany³

2022

Bull. Chem. Soc. Eth.

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“…The C=O and C=C stretch modes are scanned in spectral range 1850-1300 cm −1 (Dos Santos et al 2021;Lin et al 2021;Zhou et al 2021). The C=O stretch for C60-2COOH is observed at 1828 cm −1 for both IR and Raman spectra.…”

Section: Building Model Moleculesmentioning

confidence: 99%

Exploring the electronic, optical, and bioactive properties for new modified fullerenes via molecular modeling

et al. 2022

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Pristine fullerene characters are highly influenced upon surface decoration by COOH, NH2, and Li sets. The electronic, vibrational, and optical properties of pristine and modified fullerenes are well tested using DFT. QSAR descriptors are fulfilled via PM6 interface for proposed fullerenes. Results showed that C60-2Li may compete recent kesterite Cu2ZnGeSe4 solar cell which have band gap range as 1.5~1.7 eV and efficiency > 14%. The C60-2Li may represent a new row of highly efficient fabricated solar cells.MESP contours found that additive Li possesses a blue shift in Fullerene electronegative behavior towards electrophilic additions whereas additive COOH and NH2 maintain the original nucleophilic additions. Based upon QSAR values, C60-2NH2 is acknowledged as potential bioactive substrate for drug delivery. This paves the way towed multidisciplinary application of the studied fullerene system.

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“…Also, biofilm instability through reaction with structural protein ingredients and release of various biofilm ingredients to extracellular space of bacteria offered as hypothetical mechanisms for the antibacterial and antibiofilm activities of Cur nanoparticles. Tables 4 and 5 role in the treatment of parasitic infections (Busari et al, 2017;Chaubey et al, 2018;dos Santos et al,…”

Section: Potential Therapeutic Applications Of Cur Nanoformulations In Epilepsymentioning

confidence: 99%

“…Today, the increasing number of global mortality and morbidity due to parasitic infections such as Malaria , Visceral leishmaniasis , African trypanosomiasis , Trichomoniasis , and other parasitic diseases has caused much concern at the global level (Date, Joshi, & Patravale, 2007). In recent years, studies have shown that Cur nanoparticles have a special role in the treatment of parasitic infections (Busari et al, 2017; Chaubey et al, 2018; dos Santos et al, 2020; Ghosh, Banerjee, Bhandary, & Surolia, 2014; Memvanga, Coco, & Préat, 2013. In an in vivo study, Mokbel, Baiuomy, Sabry, Mohammed, and El‐Dardiry (2020) designed nanoformulations containing Cur‐gold‐praziquantel and tested its antiparasitic activity against parasite infection with Schistosoma mansoni in the C57BL/6 mice model.…”

Section: Cur Nanoformulations As Promising Strategies For the Treatme...mentioning

confidence: 99%

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khezri

Saeedi

Mohammadamini

et al. 2021

Phytotherapy Research

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Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur.Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

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Curcumin-loaded nanocapsules: Influence of surface characteristics on technological parameters and potential antimalarial activity

Cited by 25 publications

References 60 publications

Structural and optical characteristics of poly(vinyl alcohol)/carboxymethyl cellulose/ curcumin nanocomposites

Structural and optical characteristics of poly(vinyl alcohol)/carboxymethyl cellulose/ curcumin nanocomposites

Exploring the electronic, optical, and bioactive properties for new modified fullerenes via molecular modeling

A comprehensive review of the therapeutic potential of curcumin nanoformulations

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