Curcumin Loaded Nanocarriers with Varying Charges Augmented with Electroporation Designed for Colon Cancer Therapy

Kulbacka, Julita; Wilk, Kazimiera A.; Bazylińska, Urszula; Dubińska–Magiera, Magda; Potoczek, S; Saczko, Jolanta

doi:10.3390/ijms23031377

Cited by 9 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, REDOX-reactive materials have been used to generate nanocarriers that deliver therapeutic drugs to cells depending on their ROS production, particularly against cancer. 104 , 105 In settings with VL cases, nanocarrier therapies could be used to deliver drugs directly to infected HSCs, also reducing the rates of drug resistance and preventing parasites from reinitiating the infection.…”

Section: Hematopoietic Stem Cells (Hscs)mentioning

confidence: 99%

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps

Pacheco-Fernandez,

Markle,

Verma

et al. 2023

RRTM

View full text Add to dashboard Cite

Leishmaniasis is a neglected tropical disease endemic primarily to low- and middle-income countries, for which there has been inadequate development of affordable, safe, and efficacious therapies. Clinical manifestations of leishmaniasis range from self-healing skin lesions to lethal visceral infection with chances of relapse. Although treatments are available, secondary effects limit their use outside the clinic and negatively impact the quality of life of patients in endemic areas. Other non-medicinal treatments, such as thermotherapies, are limited to use in patients with cutaneous leishmaniasis but not with visceral infection. Recent studies shed light to mechanisms through which Leishmania can persist by hiding in cellular safe havens, even after chemotherapies. This review focuses on exploring the cellular niches that Leishmania parasites may be leveraging to persist within the host. Also, the cellular, metabolic, and molecular implications of Leishmania infection and how those could be targeted for therapeutic purposes are discussed. Other therapies, such as those developed against cancer or for manipulation of the ferroptosis pathway, are proposed as possible treatments against leishmaniasis due to their mechanisms of action. In particular, treatments that target hematopoietic stem cells and monocytes, which have recently been found to be necessary components to sustain the infection and provide a safe niche for the parasites are discussed in this review as potential field-deployable treatments against leishmaniasis.

show abstract

Section: Hematopoietic Stem Cells (Hscs)mentioning

confidence: 99%

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps

Pacheco-Fernandez,

Markle,

Verma

et al. 2023

RRTM

View full text Add to dashboard Cite

show abstract

“…A microscopic technique with no special sample treatments is atomic force microscopy (AFM), which is used for topographical analysis of nanomedicines. This type of morphological imaging allows to probe surfaces to obtain parameters such as roughness and other mechanical properties [83]. Recently, two nanocomplexes consisting of saponin-cholesterol were prepared and characterized by AFM.…”

Section: Morphology and Size Of Carriersmentioning

confidence: 99%

Colon Delivery of Nutraceutical Ingredients by Food-Grade Polymeric Systems: An Overview of Technological Characterization and Biological Evaluation

et al. 2023

View full text Add to dashboard Cite

The development of food-grade carriers based on EFSA and/or FDA-approved polymeric materials is an area of growing interest for the targeted delivery of bioactive compounds to the colon. Many nutraceuticals have shown promise in the local treatment of conditions that threaten quality of life, such as ulcerative colitis, Crohn’s disease, colorectal cancer, dysbiosis and other problems affecting the gut and colon. Nevertheless, their bioavailability is often limited due to poor solubility, rapid metabolism and low permeability, as well as undesirable local side effects. Encapsulation in carriers, which can protect the active ingredient from degradation and improve absorption and targeted administration in the colon, is one way to overcome these limitations. The technological characterization of these systems is important to assess their efficacy, safety and stability. In particular, morphology, size and surface properties influence their actions and interaction with the bio-phase. Meanwhile, encapsulation efficiency, profile and in vitro release kinetics are key parameters to assess the ability to reach the target site. This paper proposes a recent review of food-grade polymer-based systems for colorectal targeting of bioactive substances, focusing on their technological characterization and assessment of stability and biological activity, which are important in determining their full bench-to-bed potential.

show abstract

Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review

Oryani,

Nosrati,

Javid

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Curcumin Loaded Nanocarriers with Varying Charges Augmented with Electroporation Designed for Colon Cancer Therapy

Cited by 9 publications

References 54 publications

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps

Colon Delivery of Nutraceutical Ingredients by Food-Grade Polymeric Systems: An Overview of Technological Characterization and Biological Evaluation

Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review

Contact Info

Product

Resources

About