Curcumin-loaded self-emulsifying drug delivery system (cu-SEDDS): a promising approach for the control of primary pathogen and secondary bacterial infections in cutaneous leishmaniasis

Khan, Momin; Ali, Muhammad; Shah, Walayat; Shah, Anwar‐ul‐Haq Ali; Yasinzai, Muhammad Masoom

doi:10.1007/s00253-019-09990-x

Cited by 24 publications

(14 citation statements)

References 23 publications

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“…On the other side, heptacosane (peak 39) is only present in the Eletta campana sample (23.9%). The latter contains more complex mixture characterized by the exclusive presence of other six compounds (peaks 16,17,25,26,30,33). The quantitative differences as for myrcene (peak 4, range 6.8-26.4%), terpinolene (peak 14, 2.3-7.0%), limonene (peak 9, 1.8-4.7%) and selina-3,7(11)-diene (peak 32, 0.5-2.5%) suggest potentially relevant effects on organoleptic properties.…”

Section: Resultsmentioning

confidence: 99%

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Chemical and Bioinformatics Analyses of the Anti-Leishmanial and Anti-Oxidant Activities of Hemp Essential Oil

et al. 2021

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Industrial hemp is a multiuse crop that has been widely cultivated to produce fibers and nutrients. The capability of the essential oil (EO) from inflorescences as antimicrobial agent has been reported. However, literature data are still lacking about the hemp EO antiprotozoal efficacy in vivo. The present study aims to unravel this concern through the evaluation of the efficacy of hemp EOs (2.5 mL/kg, intraperitoneally) of three different cultivars, namely Futura 75, Carmagnola selezionata and Eletta campana, in mice intraperitoneally infected with Leishmania tropica. A detailed description of EO composition and targets-components analysis is reported. Myrcene, α-pinene and E-caryophyllene were the main components of the EOs, as indicated by the gas-chromatographic analysis. However, a prominent position in the scenario of the theoretical interactions underlying the bio-pharmacological activity was also occupied by selina-3,7(11)-diene, which displayed affinities in the micromolar range (5.4–28.9) towards proliferator-activated receptor α, cannabinoid CB2 receptor and acetylcholinesterase. The content of this compound was higher in Futura 75 and Eletta campana, in accordance with their higher scavenging/reducing properties and efficacy against the tissue wound, induced by L. tropica. Overall, the present study recommends hemp female inflorescences, as sources of biomolecules with potential pharmacological applications, especially towards infective diseases.

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Section: Resultsmentioning

confidence: 99%

“…To prepare sample solution, aliquots (12.5 µg) of EC, CS and F75 EOs were mixed in 1 mL saline solution containing 0.5% v/v dimethyl sulfoxide (DMSO) [16]. The use and percentage of DMSO as co-solvent were according to literature data [17].…”

Section: Preparation Of Sample Solutionmentioning

confidence: 99%

Chemical and Bioinformatics Analyses of the Anti-Leishmanial and Anti-Oxidant Activities of Hemp Essential Oil

et al. 2021

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“…In turn, this activity of curcumin against such bacteria as A. lwoffii [ 20 ], Proteus mirabilis [ 24 , 30 ], Serratia marcescens [ 20 , 24 ], Stenotrophomonas maltophilia [ 31 ], and Streptococcus agalactiae [ 30 ] has been examined sporadically. In the contemporary research, the in vitro ability of curcumin to inhibit microbial growth has frequently been tested against a small (4–6) number of species representing a small group of taxa, mostly E. coli , P. aeruginosa , and S. aureus , and less often Bacillus subtilis and Enterococcus faecalis (e.g., [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ]). Some works have reported the minimum inhibitory concentration (MIC) value for only one species and a single, usually reference, strain (e.g., [ 39 , 40 , 41 , 42 ]).…”

Section: Introductionmentioning

confidence: 99%

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

2020

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Curcumin, a principal bioactive substance of turmeric (Curcuma longa L.), is reported as a strong antioxidant, anti-inflammatory, antibacterial, antifungal, and antiviral agent. However, its antimicrobial properties require further detailed investigations into clinical and multidrug-resistant (MDR) isolates. In this work, we tested curcumin’s efficacy against over 100 strains of pathogens belonging to 19 species. This activity was determined by the broth microdilution method and by calculating the minimum inhibitory concentration (MIC). Our findings confirmed a much greater sensitivity of Gram-positive than Gram-negative bacteria. This study exhibited a significantly larger variation in the curcumin activity than previous works and suggested that numerous clinical strains of widespread pathogens have a poor sensitivity to curcumin. Similarly, the MICs of the MDR types of Staphylococcus aureus, S. haemolyticus, Escherichia coli, and Proteus mirabilis were high (≥2000 µg/mL). However, curcumin was effective against some species and strains: Streptococcus pyogenes (median MIC = 31.25 µg/mL), methicillin-sensitive S. aureus (250 µg/mL), Acinetobacter lwoffii (250 µg/mL), and individual strains of Enterococcus faecalis and Pseudomonas aeruginosa (62.5 µg/mL). The sensitivity of species was not associated with its affiliation to the genus, and it could differ a lot (e.g., S. pyogenes, S. agalactiae and A. lwoffii, A. baumannii). Hence, curcumin can be considered as a promising antibacterial agent, but with a very selective activity.

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“…SNEDDS have a high solubilizing capacity for lipophilic compounds, are thermodynamically stable, provide simplicity of fabrication, and have an elegant appearance [ 35 , 36 ]. They have been shown to enhance skin delivery of lipophilic solutes such as curcumin [ 37 ] and clofazimine [ 38 ]. When applied topically, a SNEDDS may be diluted by an aqueous phase coming to the skin surface from the secretion of sweat or trans epidermal water loss, and then form an occlusive topical system that has a high thermodynamic driving force for skin delivery [ 34 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Self-Nano-Emulsifying Drug Delivery Systems Containing Astaxanthin for Topical Skin Delivery

et al. 2021

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Astaxanthin (ASX) is a potent lipophilic antioxidant derived from the natural pigment that gives marine animals their distinctive red-orange colour and confers protection from ultraviolet radiation. Self nano-emulsifying drug delivery systems (SNEDDS) have been successfully developed and evaluated to increase the skin penetration of ASX and target its antioxidant and anti-inflammatory potential to the epidermis and dermis. SNEDDS were prepared using a low-temperature spontaneous emulsification method, and their physical characteristics, stability, antioxidant activity, and skin penetration were characterized. Terpenes (D-limonene, geraniol, and farnesol) were included in the SNEDDS formulations to evaluate their potential skin penetration enhancement. An HPLC assay was developed that allowed ASX recovery from skin tissues and quantification. All SNEDDS formulations had droplets in the 20 nm range, with low polydispersity. ASX stability over 28 days storage in light and dark conditions was improved and antioxidant activity was high. SNEDDS-L1 (no terpene) gave significantly increased ASX penetration to the stratum corneum (SC) and the epidermis-dermis-follicle region (E + D + F) compared to an ASX in oil solution and a commercial ASX facial serum product. The SNEDDS-containing D-limonene gave the highest ASX permeation enhancement, with 3.34- and 3.79-fold the amount in the SC and E + D + F, respectively, compared to a similar applied dose of ASX in oil. We concluded that SNEDDS provide an effective formulation strategy for enhanced skin penetration of a highly lipophilic molecule, and when applied to ASX, have the potential to provide topical formulations for UV protection, anti-aging, and inflammatory conditions of the skin.

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Curcumin-loaded self-emulsifying drug delivery system (cu-SEDDS): a promising approach for the control of primary pathogen and secondary bacterial infections in cutaneous leishmaniasis

Cited by 24 publications

References 23 publications

Chemical and Bioinformatics Analyses of the Anti-Leishmanial and Anti-Oxidant Activities of Hemp Essential Oil

Chemical and Bioinformatics Analyses of the Anti-Leishmanial and Anti-Oxidant Activities of Hemp Essential Oil

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

Novel Self-Nano-Emulsifying Drug Delivery Systems Containing Astaxanthin for Topical Skin Delivery

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