Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells

Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats

“…Thus, this parameter is important for Page 14 of 29 A c c e p t e d M a n u s c r i p t 14 differentiation of normal cells with that of rapidly proliferating cancerous cells, thereby portray the DNA transcriptional activity (Akhtar et al, 2005). In earlier reports, curcumin has been reported to reduce AgNOR pool in vitro in HeLa cell (Lewinska et al, 2014). Similarly in the present study, curcumin per se significantly reduced the AgNORs number, suggesting its role in inhibition of cell proliferation induced by DENA (Mohamed et al, 2010).…”

Spices for Prevention and Treatment of Cancers

“…Additionally, the proliferation and apoptosis of human endometrial carcinoma cells was down-regulated by curcumin through down-regulating their AR expression mediated by the Wnt signal pathway [77]. In another study, curcumin induced decrease in silver-staining nucleolar organizer region (AgNOR) protein pools which reflected the rapidity of cancer cell proliferation, which might be mediated by global DNA hypermethylation in HeLa cells [78]. Besides, tumor growth and angiogenesis in cervical cancer-implanted mice were inhibited by curcumin via down-regulating vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) and EGFR [79].…”

Nanoparticle-mediated decrease of lamin B1 pools promotes a TRF protein-based adaptive response in cultured cells

“…Briefly, cells were incubated with nanoparticles for 48 h, washed, and cultured in nanoparticle-free medium for up to 144 h, and cell cycle and metabolic activity were analyzed as previously described [16,22]. After a 24 h treatment with nanoparticles, the cell proliferation rate was established using a BrdU incorporation assay [16].…”