Curcumin-mediated lifespan extension in Caenorhabditis elegans

Liao, Vivian Hsiu‐Chuan; Yu, Chun; Chu, Yen-Ping; Li, Wen-Hsuan; Hsieh, Yi-Cheng; Wang, Teng-Ting

doi:10.1016/j.mad.2011.07.008

Cited by 236 publications

(168 citation statements)

References 70 publications

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“…Antioxidant supplements, for example, appear to either have no effect on lifespan, or to increase morbidity and mortality in humans (McCormick 2010). In contrast to the results cited above, many antioxidants appear to extend the lifespan of worms or flies (e.g., Liao et al 2011;Peng et al 2012;Shen et al 2013). These results suggest that screening drugs and supplements in lower eucaryotes may be confounded by high false discovery rates.…”

Section: Discussionmentioning

confidence: 92%

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Spindler

Mote

Flegal

2013

AGE

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Present data suggest that the consumption of individual dietary supplements does not enhance the health or longevity of healthy rodents or humans. It might be argued that more complex combinations of such agents might extend lifespan or health-span by more closely mimicking the complexity of micronutrients in fruits and vegetables, which appear to extend health-span and longevity. To test this hypothesis we treated long-lived, male, F1 mice with published and commercial combinations of dietary supplements and natural product extracts, and determined their effects on lifespan and health-span. Nutraceutical, vitamin or mineral combinations reported to extend the lifespan or health-span of healthy or enfeebled rodents were tested, as were combinations of botanicals and nutraceuticals implicated in enhanced longevity by a longitudinal study of human aging. A cross-section of commercial nutraceutical combinations sold as potential health enhancers also were tested, including Bone Restore®, Juvenon®, Life Extension Mix®, Ortho Core®, Ortho Mind®, Super K w k2®, and Ultra K2®. A more complex mixture of vitamins, minerals, botanical extracts and other nutraceuticals was compounded and tested. No significant increase in murine lifespan was found for any supplement mixture. Our diverse supplement mixture significantly decreased lifespan. Thus, our results do not support the hypothesis that simple or complex combinations of nutraceuticals, including antioxidants, are effective in delaying the onset or progress of the major causes of death in mice. The results are consistent with epidemiological studies suggesting that dietary supplements are not beneficial and even may be harmful for otherwise healthy individuals.

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Section: Discussionmentioning

confidence: 92%

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Spindler

Mote

Flegal

2013

AGE

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“…Cocoa supplementation increases the lifespan of the fruit fly Drosophila melanogaster under oxidative stress conditions (Bahadorani and Hilliker, 2008). Curcumininduced lifespan extension was reported in Drosophila and C. elegans, but not in mouse models (Suckow and Suckow, 2006;Liao et al, 2011;Shen et al, 2013a,b).…”

Section: Agingmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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“…For the heat tolerance assay, the adult day 3 worms were incubated at 37°C for 3.5 h and then transferred back to 20°C. [26][27][28][29] The survival of the worms was monitored daily. Each assay was performed in three independent trials.…”

Section: )mentioning

confidence: 99%

The longevity effect of echinacoside inCaenorhabditis elegansmediated throughdaf-16

Wang

Zhang

Liu

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Echinacoside (ECH), a natural polyphenolic compound, has been reported to possess important pharmacological activities. However, very little is known about whether or how ECH affects longevity in vivo. We have examined the effects of ECH on the life span and stress tolerance in Caenorhabditis elegans. Our studies demonstrate that the life span of wild-type worms could be extended in the presence of ECH. Furthermore, ECH was found to increase tolerance of worms to heat shock and oxidative stress, while not exerting any influence on pharyngeal pumping rate and progeny production. Our mechanistic studies indicate that supplementation of ECH increases the transcript level of daf-16. ECH treatment also modulates the nuclear localization and transcriptional activities of daf-16, thus fine tunes the expression of daf-16 target genes to promote longevity and increases stress response in C. elegans. Overall, this work reveals the longevity effect of ECH and elucidates the underpinning mechanisms.

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Curcumin-mediated lifespan extension in Caenorhabditis elegans

Cited by 236 publications

References 70 publications

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

The longevity effect of echinacoside inCaenorhabditis elegansmediated throughdaf-16

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