Curcumin-mediated Photodynamic Therapy for the treatment of oral infections—A review

Santezi, Carolina; Reina, Bárbara Donadon; Dovigo, Lívia Nordi

doi:10.1016/j.pdpdt.2018.01.016

Cited by 108 publications

(62 citation statements)

References 85 publications

(353 reference statements)

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“…22 With specific regard to the oral environment, its action includes the treatment of leukoplakia, 17 lichen planus, 23 periodontal pockets, 24 peri-implantitis, 25 and oral decontamination as well. 26,27 In the specific case of palatal ulcers during orthodontic therapy, this is the first case report to use this approach to solve this type of injury. Other studies have reported that the use of aPDT accelerated wound healing in oral mucosa right after the second day in comparison with the control group and the group with the laser applied alone.…”

Section: Discussionmentioning

confidence: 97%

“…When compared with antibiotic therapy used alone, 10 the present clinical results demonstrated a substantial relief from the painful sensation in a short period of time, achieving healthy tissue marked by the absence of bleeding in few days and more organized wound healing, which resulted from the combination with/activation by light and protocols proposed here. 26,27,34,35 In the present report, no pain scale measurement was applied (e.g. visual analogic scale).…”

Section: Discussionmentioning

confidence: 98%

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The Combination of Antimicrobial Photodynamic Therapy and Photobiomodulation Therapy for the Treatment of Palatal Ulcers: A Case Report

Maya¹,

Ladeira

Maya

et al. 2020

J Lasers Med Sci

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Introduction: One of the unexpected side effects of the Haas type palatal expander is ulcers progressing to necrotic lesions in the palatal area due to poor hygiene. The use of antibiotic therapy is mandatory. However, long periods of healing/pain and the need for a systemic host response with the aid of metabolization, especially in children, are issues that should be taken into account in the management of this type of injury. Since phototherapy modalities (antimicrobial photodynamic therapy [aPDT] and photobiomodulation therapy [PBMT]) are able to enhance and accelerate the healing process and reduce the bacterial load, this case report aimed to describe the use of the above-mentioned therapies to treat palatal ulcers occurring during orthodontic expansion. Case Report: The patient, a 10-year-old boy, with a chief complaint of bleeding and continuous pain in the region of his expander was verified on a follow-up visit. After a dental examination, the expander was removed and two necrotic lesions which were in contact with the acrylic part of the tooth-tissue expander were found in the palatal region. The proposal was to use one aPDT session with methylene blue followed by 4 sessions of PBMT with a red laser diode. On the 5th day, reorganized tissue was verified, with the absence of bleeding, swelling, and pain. On the 20th day of follow-up, the area showed no signs of inflammation, healthy tissue without any pathological clinical symptoms, and complete wound healing. Conclusion: The concomitant use of PBMT and aPDT therapies may be considered feasible as an adjunct treatment to manage palatal ulcers resulting from the incorrect use of tooth-tissue types of expanders

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

The Combination of Antimicrobial Photodynamic Therapy and Photobiomodulation Therapy for the Treatment of Palatal Ulcers: A Case Report

Maya¹,

Ladeira

Maya

et al. 2020

J Lasers Med Sci

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“…36 Recent studies have shown that the anticancer properties of curcumin can be improved by incorporating it in nanoparticles. [39][40][41] In previous work, we reported that curcumin in LDH could present good anticancer properties also phototoxicity upon using blue light LED irradiation (PDT). [39][40][41] In previous work, we reported that curcumin in LDH could present good anticancer properties also phototoxicity upon using blue light LED irradiation (PDT).…”

Section: Discussionmentioning

confidence: 99%

Photodynamic treatment with anionic nanoclays containing curcumin on human triple‐negative breast cancer cells: Cellular and biochemical studies

Khorsandi

Hosseinzadeh²,

Shahidi

2018

J of Cellular Biochemistry

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Photodynamic treatment is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with activation of a photosensitizer agent at a specific light. Little is known, however, about the phototoxic properties of curcumin, as a natural phenolic compound, against different types of cancers. It is generally accepted that cellular damage occurs during photo treatment. There is a limitation in using of curcumin as a drug due to its low solubility, but nanoparticles such as anionic nanoclays or layered double hydroxide (LDH) could overcome it. The aim of this study was to investigate cellular responses to curcumin‐LDH nanoparticles after photodynamic treatment of MDA‐MB‐231 human breast cancer cells. For this purpose, the MDA‐MB‐231 human breast cancer cell line treated with curcumin‐LDH nanoparticle and then irradiated (photodynamic treatment). After irradiation, lactate dehydrogenase assay, clonogenic cell survival, cell death mechanisms such as autophagy and apoptosis were determined. Cell cycle distribution after photodynamic therapy (PDT) and also intracellular reactive oxygen species (ROS) generation were measured. The result showed that curcumin‐LDH–PDT has a cytotoxic and antiprolifrative effect on MDA‐MB‐231 human breast cancer cells. Curcumin‐LDH–PDT induced autophagy, apoptosis, and G0/G1 cell cycle arrest in human breast cancer cell line. Intracellular ROS increased in MDA‐MB‐231 cancer cell line after treatment with curcumin‐LDH along with irradiation. The results suggest that curcumin‐LDH nanoparticle could be considered as a novel approach in the photodynamic treatment of breast cancer.

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“…Curcumin is a natural polyphenolic compound extracted from plants sources that possess antimicrobial properties [ 48 , 49 ]. Additionally, photoactivated curcumin appears to be an effective treatment strategy for persistent root canal infections [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Light Activated Disinfection in Root Canal Treatment—A Focused Review

Ali

Neelakantan

2018

Dentistry Journal

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Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the effectiveness of this mode of root canal disinfection. While most studies offer an important understanding of the effectiveness of LAD on monospecies biofilms, few have offered credence to the fact that infections of the root canal system are mediated by polymicrobial biofilms. Hence, it is imperative to understand the effect of LAD on polymicrobial biofilms both in terms of microbial killing and the changes in the biofilm architecture. The aim of this review was to systematically review the literature to evaluate the effect of LAD on dual and multispecies biofilms and demonstrate the antibiofilm effect of LAD. Two databases (PubMed and Scopus) were searched to identify eligible studies using a combination of key words. These studies were reviewed to draw conclusions on the effect of LAD on dual and multi species biofilm and the antibiofilm effect of LAD. It was found that LAD alone may be unable to eradicate dual and multispecies biofilms, but it may enhance the effect of conventional canal debridement strategies. Novel formulations of photosensitizers with nanoparticles showed the potential to inhibit biofilm formation and/or disrupt the biofilm architecture.

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Curcumin-mediated Photodynamic Therapy for the treatment of oral infections—A review

Cited by 108 publications

References 85 publications

The Combination of Antimicrobial Photodynamic Therapy and Photobiomodulation Therapy for the Treatment of Palatal Ulcers: A Case Report

The Combination of Antimicrobial Photodynamic Therapy and Photobiomodulation Therapy for the Treatment of Palatal Ulcers: A Case Report

Photodynamic treatment with anionic nanoclays containing curcumin on human triple‐negative breast cancer cells: Cellular and biochemical studies

Light Activated Disinfection in Root Canal Treatment—A Focused Review

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