Curcumin nano-micelle induced testicular toxicity in healthy rats; evidence for oxidative stress and failed homeostatic response by heat shock proteins 70-2a and 90

Radmanesh, Fereshteh; Razi, Mazdak; Jalali, Ali Shalizar

doi:10.1016/j.biopha.2021.111945

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…In addition to synthetic NPs, the presence of EVs also provides a direct drug delivery route to colon mucosa for the treatment of IBD. Compared with the synthetic NPs, which will lead to cell stress, apoptosis, inflammatory body activation and other side effects, EVs are non-toxic, low immunogenicity and can be produced in large scale, may have better application prospects ( Hu and Palic, 2020 ; Radmanesh et al, 2021 ). In a variety of EVs, plants derived EVs contain bioactive lipids, proteins, ribonucleic acids and other pharmacologically active molecules, which can be used as natural nano carriers.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plant-based drug delivery system for inflammatory bowel disease

Wang

Lyu

et al. 2023

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease. The incidence rate of IBD is increasing year by year, which seriously endangers human health worldwide. More and more studies have shown that medicinal plants or their main phytochemicals have great potential in the treatment of intestinal diseases. However, the disadvantages of low oral absorption rate, low biological distribution and low systemic bioavailability limit their clinical application to a certain extent. In recent years, the application of nanotechnology has made it possible to treat IBD. Nanoparticles (NPs) drug delivery system has attracted special attention in the treatment of IBD due to its small size, low immunogenicity, surface modification diversity, targeting and other advantages. Synthetic nanoparticles and extracellular vehicles (EVs) can deliver drug components to colon, and play a role in anti-inflammation, regulation of oxidative stress, improvement of intestinal flora, etc. In addition, some medicinal plants can secrete EVs by themselves, and carry biological molecules with therapeutic effects to act on the intestine. Some clinical trials to evaluate the safety, tolerance, toxicity and effectiveness of EVs-loaded drugs in IBD are also progressing steadily. This review introduces that synthetic nanoparticles and medicinal plants derived EVs can play an important role in the treatment of IBD by carrying the effective active phytochemicals of medicinal plants, and discuss the limitations of current research and future research needs, providing a scientific and reliable basis and perspective for further clinical application and promotion.

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Section: Discussionmentioning

confidence: 99%

Medicinal plant-based drug delivery system for inflammatory bowel disease

Wang

Lyu

et al. 2023

Front. Pharmacol.

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“…Therapeutic medications are being delivered via both natural and synthetic dispersion systems (DDS), such as mammalian and plant-derived exosomes and liposomes and microspheres. However, the artificial nanoparticles may cause apoptosis, cell stress, inflammation, and other adverse consequences (Radmanesh et al, 2021). Exosomes from citrus and lemons have anti-inflammatory and antioxidant properties; exosomes from edible plants, such grapefruit, tomato, blueberries, and shiitake mushrooms, have anti-inflammatory properties and exosomes from apples and carrots may influence intestinal transporters (Y.…”

Section: Confronting Inflammatory Bowel Disease and The Looming Threa...mentioning

confidence: 99%

Bridging Nature and Nanotechnology: Harnessing Plant-Derived Exosome-Like Nanoparticles for Targeted Therapy in Inflammatory Diseases

Singh,

Jawanda,

Soni

et al. 2024

Preprint

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Exosomes are nano-sized extracellular vesicles released by cells that contain nucleic acids, proteins, lipids, and other bioactive compounds that play a role in the body's physiological and pathological processes. Exosomes have significant and distinct benefits over synthetic carriers such as liposomes and nanoparticles in the realm of illness diagnostics and therapy due to their endogeneity and heterogeneity. Exosomes are classified as either natural or designed, depending on whether they have been deliberately altered. Natural exosomes are further classified as either animal-derived or plant-derived exosomes. Plant-derived exosome-like nanoparticles (PDENs) are comprised of numerous kinds of bioactive biomolecules. As an alternative cell-free therapeutic strategy, they have the ability to transfer nano-bioactive chemicals to the human body, resulting in diverse anti-inflammatory, antioxidant, and anti-tumour effects. This review focuses on the beneficial effects of plant-derived exosomes against a range of inflammatory conditions, including as periodontitis, inflammatory bowel disease (IBD), autoimmune skin disorders, and inflammation of the liver, lungs, and intestines. Inflammatory disorders are a major issue because of their widespread influence on both personal health and public healthcare systems. Since these illnesses are persistent, the affected people's quality of life is negatively impacted and long-term morbidity is exacerbated. The complicated interaction of genetic, environmental, and immunological variables in the development of various disorders makes effective prevention and therapy more challenging. Plant exosomes present a promising avenue for developing novel therapeutic strategies against inflammatory diseases, offering unique advantages over other alternatives. In order to exploit this efficient carrier, future research will concentrate on creating a PELNV delivery system with high stability, transdermal volume, and ease of administration. Plant exosomes have the potential to become reliable therapeutic agents for a range of common disorders if they are targeted and generated with interdisciplinary expertise.

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“…For the assessment of testicular tissue malondialdehyde (MDA) level at 550 nm, the absorbance of the test was monitored immediately after all the reagents (according to the manufacturer) were added to a 1,000 ml reaction in which 200 ml of supernatant was added, and 800 ml of different reagents were added [24]. Measurement of superoxide dismutase (SOD) level was investigated based on an assay kit (Nanjing Jiancheng Bioengineering Institute, Nanjing, China) and the method of xanthine oxidase to measure its absorbance at 450 nm [23].…”

Section: Determination Of the Antioxidant Biomarkers In Testismentioning

confidence: 99%

“…Measurement of superoxide dismutase (SOD) level was investigated based on an assay kit (Nanjing Jiancheng Bioengineering Institute, Nanjing, China) and the method of xanthine oxidase to measure its absorbance at 450 nm [23]. At 340 and 550 nm, respectively, the absorbance of the testicular glutathione peroxidase (GPX) and catalase (CAT) reactions was monitored in 300 ml, including 40 ml of supernatant and 260 ml from the different reagents of the kit [24]. Testicular total antioxidant capacity (TAC) assuagement was achieved by incubating the reaction mixture for 5 min at room temperature.…”

Section: Determination Of the Antioxidant Biomarkers In Testismentioning

confidence: 99%

“…Testicular total antioxidant capacity (TAC) assuagement was achieved by incubating the reaction mixture for 5 min at room temperature. The mixture had 1,000 μl reaction buffer containing 400 μl distilled water, 100 μl supernatant, and 500 μl ABTS buffer, and monitoring absorbance at 414 nm after incubation was complete [24]. The total oxidant status (TOS) level analysis was done in 240 ml, including 30 ml of supernatant and 210 ml from several reagents from the kit, as instructed by the manufacturer.…”

Section: Determination Of the Antioxidant Biomarkers In Testismentioning

confidence: 99%

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Antioxidant Properties of Pistacia vera against the Effects of Phenylhydrazine-Induced Hemolytic Anemia on Male Fertility in Mice

Falahati-pour,

Khoradmehr,

Baghery

et al. 2024

Andrologia

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Objective. The reproductive system can be adversely affected by anemia, characterized by elevated free radical production and lipid peroxidation. Conversely, the pistachio is well-known for its antioxidant capabilities. In this study, a mouse model was employed to investigate the safeguarding effects of the aqueous extract of pistachio (Pistacia vera) against oxidative stress induced by phenylhydrazine (PHZ)-triggered hemolytic anemia. Materials and methods. Forty-eight male mice were distributed into six distinct experimental groups (n = 8): control, PHZ, PHZ + 20Pis, PHZ + 80Pis, PHZ + 160Pis, and 80Pis groups. The experimental groups were administered a PHZ dose of 80 mg/kg/48 hr, along with pistachio doses of 20, 80, and 160 mg/kg/day, delivered intraperitoneally. After a period of 35 days, an assessment of sperm count, motility, morphology, and viability was conducted. Additionally, sperm chromatin quality was evaluated through Chromomycin A3, aniline blue, and toluidine blue staining. Hematoxylin–eosin staining was performed to examine the total diameter of seminiferous tubes and spermatogenic cells. Hormonal levels (FSH, LH, T) and antioxidant levels were analyzed using standard kits. Results. The PHZ groups exhibited a noteworthy decrease in various sperm parameters, as well as diminished chromatin quality assays and reduced levels of sex hormones when compared to the control group. Moreover, the morphometric evaluation indicated a substantial reduction in spermatogonia cell number, spermatid count, tubule count, seminiferous diameters, and seminiferous area in the PHZ group. Notably, the Pis group demonstrated the highest concentration of antioxidant contents. Conclusion. The protective impact of P. vera extract against PHZ-induced anemia on the male reproductive system in mice may be attributed to its abundant antioxidant components, which possess therapeutic properties at elevated levels.

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Curcumin nano-micelle induced testicular toxicity in healthy rats; evidence for oxidative stress and failed homeostatic response by heat shock proteins 70-2a and 90

Cited by 8 publications

References 41 publications

Medicinal plant-based drug delivery system for inflammatory bowel disease

Medicinal plant-based drug delivery system for inflammatory bowel disease

Bridging Nature and Nanotechnology: Harnessing Plant-Derived Exosome-Like Nanoparticles for Targeted Therapy in Inflammatory Diseases

Antioxidant Properties of Pistacia vera against the Effects of Phenylhydrazine-Induced Hemolytic Anemia on Male Fertility in Mice

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