Curcumin nanoparticles incorporated collagen-chitosan scaffold promotes cutaneous wound healing through regulation of TGF-β1/Smad7 gene expression

Rezaii, Malakeh; Oryan, Shahrbanoo; Javeri, Arash

doi:10.1016/j.msec.2018.12.143

Cited by 88 publications

(56 citation statements)

References 38 publications

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“…Rezaii and co-workers prepared collagen-chitosan scaffolds incorporated with curcumin nanoparticles for cutaneous wound healing. The wound healing analysis in vivo utilizing male Wistar mice showed a significant contraction of the wound area treated with curcumin-nanoparticle loaded scaffolds when compared to the plain scaffold, indicating that the incorporation of curcumin nanoparticles into the scaffolds resulted in improved wound closure [ 154 ]. Venkatasubbu and Anusuya formulated curcumin nanocomposite loaded with silver nanoparticles and prepared from poly vinyl alcohol.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…Biocomposite films made from gelatin (a collagen derivative) and chitin nanofibres have been designed for various medical applications, including wound-dressing [170]. Recently, it was shown that the addition of curcumin particles within a chitosan/collagen scaffold structure enhances cutaneous wound healing by regulating the complex interactions happening during the process [171].…”

Section: Wound-dressingmentioning

confidence: 99%

Marine-Derived Polymeric Materials and Biomimetics: An Overview

et al. 2020

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The review covers recent literature on the ocean as both a source of biotechnological tools and as a source of bio-inspired materials. The emphasis is on marine biomacromolecules namely hyaluronic acid, chitin and chitosan, peptides, collagen, enzymes, polysaccharides from algae, and secondary metabolites like mycosporines. Their specific biological, physicochemical and structural properties together with relevant applications in biocomposite materials have been included. Additionally, it refers to the marine organisms as source of inspiration for the design and development of sustainable and functional (bio)materials. Marine biological functions that mimic reef fish mucus, marine adhesives and structural colouration are explained.

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“…Due to the anti-oxidative, anti-inflammatory and anti-tumoral activity of CUR, this natural active material has been selected for reducing the inflammations in different studies [33]. According to various studies, CUR triggered anti-inflammatory, bioactivity and biocompatibility in different structures, when combined with silk, gelatin, collagen and chitosan [34][35][36][37]. CUR has also been studied in combination with different polymers to produce electrospun scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

et al. 2020

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Appropriate selection of suitable materials and methods is essential for scaffolds fabrication in tissue engineering. The major challenge is to mimic the structure and functions of the extracellular matrix (ECM) of the native tissues. In this study, an optimized 3D structure containing poly(3-hydroxybutyrate) (P3HB), multiwalled carbon nanotubes (MCNTs) and curcumin (CUR) was created by electrospinning a novel biomimetic scaffold. CUR, a natural anti-inflammatory compound, has been selected as a bioactive component to increase the biocompatibility and reduce the potential inflammatory reaction of electrospun scaffolds. The presence of CUR in electrospun scaffolds was confirmed by 1H NMR and Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed highly interconnected porosity of the obtained 3D structures. Addition of up to 20 wt% CUR has enhanced mechanical properties of the scaffolds. CUR has also promoted in vitro bioactivity and hydrolytic degradation of the electrospun nanofibers. The developed P3HB-MCNT composite scaffolds containing 20 wt% of CUR revealed excellent in vitro cytocompatibility using mesenchymal stem cells and in vivo biocompatibility in rat animal model study. Importantly, the reduced inflammatory reaction in the rat model after 8 weeks of implantation has also been observed for scaffolds modified with CUR. Overall, newly developed P3HB-MCNTs-CUR electrospun scaffolds have demonstrated their high potential for tissue engineering applications.

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Curcumin nanoparticles incorporated collagen-chitosan scaffold promotes cutaneous wound healing through regulation of TGF-β1/Smad7 gene expression

Cited by 88 publications

References 38 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Marine-Derived Polymeric Materials and Biomimetics: An Overview

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

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