Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

Kanwal, Qudsia; Ahmed, Mahmood; Hamza, Muhammad; Ahmad, Muhammad; Atiq-ur-Rehman,; Yousaf, Numan; Javaid, Arshad; Anwar, Aneela; Khan, Iqra Haider; Muddassar, Muhammad

doi:10.1039/d3ra01432k

Cited by 15 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The physical properties of materials depend on production routes, surface-to-volume ratio, and grain boundaries that affect the electrical, optical, mechanical, magnetic, and electrochemical properties of the materials ( Jeevanandam et al, 2018 ; Khan I. et al, 2019 ; Kanwal et al, 2023 ). As a result, the conductivity at the grain boundary and other surface characteristics like roughness play an important role in the energy storage of materials.…”

Section: Synthesis Methods and Morphological Study Of Mo Materialsmentioning

confidence: 99%

Recent progress in metal oxide-based electrode materials for safe and sustainable variants of supercapacitors

Asghar,

Khan,

Hakami

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

A significant amount of energy can be produced using renewable energy sources; however, storing massive amounts of energy poses a substantial obstacle to energy production. Economic crisis has led to rapid developments in electrochemical (EC) energy storage devices (EESDs), especially rechargeable batteries, fuel cells, and supercapacitors (SCs), which are effective for energy storage systems. Researchers have lately suggested that among the various EESDs, the SC is an effective alternate for energy storage due to the presence of the following characteristics: SCs offer high-power density (PD), improvable energy density (ED), fast charging/discharging, and good cyclic stability. This review highlighted and analyzed the concepts of supercapacitors and types of supercapacitors on the basis of electrode materials, highlighted the several feasible synthesis processes for preparation of metal oxide (MO) nanoparticles, and discussed the morphological effects of MOs on the electrochemical performance of the devices. In this review, we primarily focus on pseudo-capacitors for SCs, which mainly contain MOs and their composite materials, and also highlight their future possibilities as a useful application of MO-based materials in supercapacitors. The novelty of MO’s electrode materials is primarily due to the presence of synergistic effects in the hybrid materials, rich redox activity, excellent conductivity, and chemical stability, making them excellent for SC applications.

show abstract

Section: Synthesis Methods and Morphological Study Of Mo Materialsmentioning

confidence: 99%

Recent progress in metal oxide-based electrode materials for safe and sustainable variants of supercapacitors

Asghar,

Khan,

Hakami

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…A large number of natural drugs antagonize the UHRF1 effects in vitro , but need to be improved in order to be employed for anti-cancer therapy. Indeed, there are several drawbacks of natural compounds, e.g., curcumin and flavonoids, such as quick systemic elimination, poor pharmacokinetics, poor absorption, low water solubility, fast metabolism, low bioavailability, low penetration-targeting efficacy, and instability against environmental factors [ 171 , 172 ]. The use of nano-carriers can resolve these issues [ 171 ], as it has been also suggested for curcumin and flavonoids [ 171 , 173 ].…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Natural and Synthetic Anticancer Epidrugs Targeting the Epigenetic Integrator UHRF1

et al. 2023

View full text Add to dashboard Cite

Cancer is one of the leading causes of death worldwide, and its incidence and mortality are increasing each year. Improved therapeutic strategies against cancer have progressed, but remain insufficient to invert this trend. Along with several other risk factors, abnormal genetic and epigenetic regulations play a critical role in the initiation of cellular transformation, as well as tumorigenesis. The epigenetic regulator UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multidomain protein with oncogenic abilities overexpressed in most cancers. Through the coordination of its multiple domains and other epigenetic key players, UHRF1 regulates DNA methylation and histone modifications. This well-coordinated dialogue leads to the silencing of tumor-suppressor genes (TSGs) and facilitates tumor cells’ resistance toward anticancer drugs, ultimately promoting apoptosis escape and uncontrolled proliferation. Several studies have shown that the downregulation of UHRF1 with natural compounds in tumor cells induces the reactivation of various TSGs, inhibits cell growth, and promotes apoptosis. In this review, we discuss the underlying mechanisms and the potential of various natural and synthetic compounds that can inhibit/minimize UHRF1’s oncogenic activities and/or its expression.

show abstract

In‐Vitro Antimicrobial, Antidiabetic and Anticancer Activities of Calyptocarpus Vialis Extract and its Integration with Computational Studies

Bachhar,

Joshi,

Shekher Mishra

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Calyptocarpus vialis (C. vialis), a plant of Asteraceae family exhibits nutritional value, antioxidant properties and has potential for various other biomedical applications. The present study is focused to assess the antimicrobial, antidiabetic, and anticancer potential of C. vialis extract and its integration with computational studies. The antimicrobial activity is performed against the Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis) pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli) bacteria and Saccharomyces cerevisiae (S. cerevisiae), Candida albicans (C. albicans) fungi using disc diffusion method. Maximum Zone of Inhibition (ZOI) of 37±3.2 and 35±2.9 mm is obtained for S. aureus and B. subtilis respectively, whereas ZOI of 39±2.8 mm is obtained against C. albicans at dose of 500 μg/mL. The extract shows strong α‐amylase inhibition activity with IC50 ~46.8±0.81 μg/mL inferring about its antidiabetic potential. Anticancer activity of C. vialis extract is checked against HCT‐116 and DU‐145 cell lines using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium‐bromide (MTT) assay, which shows excellent anticancer activity with IC50 value of 38.09±0.65 μg/ml and 36.34±1.05 μg/ml respectively. The obtained results are further verified using computational studies considering interaction among phytochemicals and selected targets. Extract is found potent for biological activities and promising candidate for development of new drugs.

show abstract

Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

Abstract: Curcumin is an extensively studied natural compound due to its extensive biological applications.

Cited by 15 publications

References 51 publications

Recent progress in metal oxide-based electrode materials for safe and sustainable variants of supercapacitors

Recent progress in metal oxide-based electrode materials for safe and sustainable variants of supercapacitors

Natural and Synthetic Anticancer Epidrugs Targeting the Epigenetic Integrator UHRF1

In‐Vitro Antimicrobial, Antidiabetic and Anticancer Activities of Calyptocarpus Vialis Extract and its Integration with Computational Studies

Contact Info

Product

Resources

About