Curcumin-PLGA based nanocapsule for the fluorescence spectroscopic detection of dopamine

Zakaria, Hanine; Kurdi, Riham El; Patra, Digambara

doi:10.1039/d2ra01679f

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…Additionally, some herbal compounds have shown dopaminergic properties; for example, Hepad S1, a Korean medicinal herbal combination, is an important source of dopamine with neuroprotective properties that improve Parkinson’s symptoms; it could modulate adverse cellular events such as inflammation and oxidation in neuronal cells [ 15 ]. Curcumine has shown neuroprotective properties and is an important component of dopamine [ 16 ], and Hordenine, a natural compound of germinated barley, is an agonist of the dopamine D2 receptor [ 17 ]. These and other herbs have been mainly studied in neuronal diseases, with less research in nonneuronal diseases.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies

et al. 2023

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Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the management of diseases related to the nervous system. However, DA receptors have been identified in nonneuronal tissues, which has been related to their therapeutic potential in pathologies such as sepsis or septic shock, blood pressure, renal failure, diabetes, and obesity, among others. In addition, DA and dopaminergic drugs have shown anti-inflammatory and antioxidant properties in different kinds of cells. Aim: To compile the mechanism of action of DA and the main dopaminergic drugs and show the findings that support the therapeutic potential of these molecules for the treatment of neurological and non-neurological diseases considering their antioxidant and anti-inflammatory actions. Method: We performed a review article. An exhaustive search for information was carried out in specialized databases such as PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web of Science, Bookshelf, DrugBank, Livertox, and Clinical Trials. Results: We showed that DA and dopaminergic drugs have emerged for the management of neuronal and nonneuronal diseases with important therapeutic potential as anti-inflammatories and antioxidants. Conclusions: DA and DA derivatives can be an attractive treatment strategy and a promising approach to slowing the progression of disorders through repositioning.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies

et al. 2023

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“…This resulted in a shift in the emission wavelength and a further change in fluorescence. Similarly, a blue shift in the emission wavelength of CUR was found in Tween 80 micellar nanocurcumin prepared by Pinilla-Peñalver et al ( 2020) and Curcumin-PLGA prepared by Zakaria et al (2022). It was observed that the uptake of CUR-LF NPs was stronger than that of free CUR.…”

Section: Cellular Uptakementioning

confidence: 64%

Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: Characterization, neuroprotective effect and in vivo pharmacokinetic study

Tan

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Curcumin (CUR) is a natural polyphenol extract with significant antioxidant and anti-inflammatory effects, which indicates its great potential for neuroprotection. Lactoferrin (LF), a commonly used oral carrier and targeting ligand, has not been reported as a multifunctional nanocarrier for nose-to-brain delivery. This study aims to develop a nose-to-brain delivery system of curcumin-lactoferrin nanoparticles (CUR-LF NPs) and to further evaluate the neuroprotective effects in vitro and brain accumulation in vivo. Herein, CUR-LF NPs were prepared by the desolvation method with a particle size of 84.8 ± 6.5 nm and a zeta potential of +22.8 ± 4.3 mV. The permeability coefficient of CUR-LF NPs (4.36 ± 0.79 × 10−6 cm/s) was 50 times higher than that of CUR suspension (0.09 ± 0.04 × 10−6 cm/s) on MDCK monolayer, indicating that the nanoparticles could improve the absorption efficiency of CUR in the nasal cavity. Moreover, CUR-LF NPs showed excellent protection against Aβ25-35-induced nerve damage in PC12 cells. In vivo pharmacokinetic studies showed that the brain-targeting efficiency of CUR-LF NPs via IN administration was 248.1%, and the nose-to-brain direct transport percentage was 59.7%. Collectively, nose-to-brain delivery of CUR-LF NPs is capable of achieving superior brain enrichment and potential neuroprotective effects.

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“…10 In view of the coexistence of AC and DA, there is a demand to distinguish their analytical signals when monitoring the biological level of DA. In recent years, there have been many methods used to detect DA and AC, such as high-performance liquid chromatography, 11 fluorescence, 12 spectrophotometry 13 and mass spectrometry. 14 However, these methods often require specialized operations, long analysis times, high costs and complex equipment.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous and sensitive detection of dopamine and acetaminophen at a glassy carbon electrode modified with a carbonized-ZIF-67/Super P nanocomposite

Li,

Yang,

Han

et al. 2024

New J. Chem.

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Curcumin-PLGA based nanocapsule for the fluorescence spectroscopic detection of dopamine

Abstract: The main purpose of this paper is to design curcumin loaded PLGA nanocapsules for the selective detection of dopamine using fluorescence spectroscopy.

Cited by 15 publications

References 33 publications

Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies

Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies

Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: Characterization, neuroprotective effect and in vivo pharmacokinetic study

Simultaneous and sensitive detection of dopamine and acetaminophen at a glassy carbon electrode modified with a carbonized-ZIF-67/Super P nanocomposite

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