Curcumin polymeric membranes for postoperative peritoneal adhesion: Comparison of nanofiber vs. film and phospholipid-enriched vs. non-enriched formulations

Babadi, Delaram; Rabbani, Shahram; Akhlaghi, Sarah; Haeri, Azadeh

doi:10.1016/j.ijpharm.2021.121434

Cited by 12 publications

(9 citation statements)

References 60 publications

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“…Nanofibers loaded with CUR showed lower adhesion grades compared to blank PCL nanofibers. The authors suggest further investigation and long-term studies in vivo …”

Section: Types Of Antiadhesive Nanofibrous Materialsmentioning

confidence: 98%

“…Last, but not least, in vivo experiments bring the most valuable outcomes. Some of the studies are performed on small animals, such as rats or mice. ,,,− ,,, Tendon and epidural antiadhesion/adhesion properties were mostly tested on rabbit animal models, as in studies. ,, Utilization of higher animals for the assessment of antiadhesive properties in abdominal surgeries was reported in our previous studies. − …”

Section: Assessment Of Antiadhesive Propertiesmentioning

confidence: 99%

“…The authors suggest further investigation and long-term studies in vivo. 24 5.1.3. Hydrophilic Nanofibers.…”

Section: Types Of Antiadhesive Nanofibrous Materialsmentioning

confidence: 99%

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Antiadhesive Nanofibrous Materials for Medicine: Preventing Undesirable Tissue Adhesions

et al. 2023

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Undesirable postoperative tissue adhesions remain among the most common complications after surgery. Apart from pharmacological antiadhesive agents, various physical barriers have been developed in order to prevent postoperative tissue adhesions. Nevertheless, many introduced materials suffer from shortcomings during in vivo application. Thus, there is an increasing need to develop a novel barrier material. However, various challenging criteria have to be met, so this issue pushes the research in materials to its current limits. Nanofibers play a major role in breaking the wall of this issue. Due to their properties, such as a large surface area for functionalization, tunable degradation rate, or the possibility of layering individual nanofibrous materials, it is feasible to create an antiadhesive surface while maintaining biocompatibility. There are many ways to produce nanofibrous material; electrospinning is the most used and versatile technique. This review reveals the different approaches and puts them into context.

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“…Nanofibers loaded with CUR showed lower adhesion grades compared to blank PCL nanofibers. The authors suggest further investigation and long-term studies in vivo …”

Section: Types Of Antiadhesive Nanofibrous Materialsmentioning

confidence: 98%

Section: Assessment Of Antiadhesive Propertiesmentioning

confidence: 99%

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Antiadhesive Nanofibrous Materials for Medicine: Preventing Undesirable Tissue Adhesions

et al. 2023

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“…Then, the gene expression of fibrinogen and collagen I, as well as pro-inflammatory cytokine TGF-β1, in injured peritoneum and/or adhesion tissues were determined by qRT-PCR after 7 d. Figure f shows that the expression levels of fibrinogen, collagen I and TGF-β1 mRNA in ChemPatch group were significantly lower than those in the controls. It has been proven that curcumin could increase the fibrinolytic activity around the wound area via upregulating urokinase-like plasminogen activator, and decreasing collagen synthesis, which can reduce postoperative intra-abdominal adhesion formation . Collectively, there are a series of possible antiadhesion mechanisms involved in ChemPatch, such as creating a physical barrier of wound surfaces, promoting peritoneal repair, modulating the inflammatory response, enhancing fibrinolysis, and reducing collagen synthesis.…”

mentioning

confidence: 99%

“…It has been proven that curcumin could increase the fibrinolytic activity around the wound area via upregulating urokinase-like plasminogen activator, 54 and decreasing collagen synthesis, 55 which can reduce postoperative intra-abdominal adhesion formation. 56 Collectively, there are a series of possible antiadhesion mechanisms involved in ChemPatch, such as creating a physical barrier of wound surfaces, promoting peritoneal repair, modulating the inflammatory response, enhancing fibrinolysis, and reducing collagen synthesis.…”

mentioning

confidence: 99%

Light-Activated Chemically Reactive Fibrous Patch Revolutionizes Wound Repair Through the Prevention of Postoperative Adhesion

Chen

Zhou

et al. 2023

Nano Lett.

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A light-activated chemically reactive fibrous patch (ChemPatch) with tissue adhesion and wound healing activity was developed for preventing postoperative peritoneal adhesion. ChemPatch was constructed by an integrative electrospinning fabrication strategy, generating multifunctional PCL-NHS fibers encapsulating antioxidant curcumin and MnO 2 nanoparticles. ChemPatch exhibited excellent photothermal conversion, which not only reformed the physical state to match the tissue but also improved conjugation between ChemPatch and tissues, allowing for strong attachment. Importantly, ChemPatch possessed good antioxidant and radical scavenging activity, which protected cells in an oxidative microenvironment and improved tissue regeneration. Particularly, ChemPatch acted as a multifunctional barrier and could not only promote reepithelialization and revascularization in wound defect model but simultaneously ameliorate inflammation and prevent postoperative peritoneal adhesion in a mouse cecal defect model. Thus, ChemPatch represents a dual-active bioadhesive barrier for reducing the incidence and severity of peritoneal adhesions.

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A review of preparation methods and biomedical applications of poly(ε-caprolactone)-based novel formulations

Taghizadeh,

Heidari,

Mostafavi

et al. 2024

J Mater Sci

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Curcumin polymeric membranes for postoperative peritoneal adhesion: Comparison of nanofiber vs. film and phospholipid-enriched vs. non-enriched formulations

Cited by 12 publications

References 60 publications

Antiadhesive Nanofibrous Materials for Medicine: Preventing Undesirable Tissue Adhesions

Antiadhesive Nanofibrous Materials for Medicine: Preventing Undesirable Tissue Adhesions

Light-Activated Chemically Reactive Fibrous Patch Revolutionizes Wound Repair Through the Prevention of Postoperative Adhesion

A review of preparation methods and biomedical applications of poly(ε-caprolactone)-based novel formulations

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