Curcumin potentiates the ErbB receptors inhibitor Afatinib for enhanced antitumor activity in malignant mesothelioma

Benvenuto, Monica; Nardozi, Daniela; Palumbo, Camilla; Focaccetti, Chiara; Carrano, Raffaele; Angiolini, Valentina; Cifaldi, Loredana; Lucarini, Valeria; Mancini, Patrizia; Kërpi, Bora; Currenti, Walter; Bei, Roberto; Masuelli, Laura

doi:10.1080/09637486.2023.2251723

Cited by 1 publication

(1 citation statement)

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“…CUR is a pleiotropic molecule, able to target several signaling pathways involved in carcinogenesis [ 3 , 4 , 5 , 6 ]. Indeed, CUR is able to suppress proliferation, to induce apoptosis, to inhibit epithelial mesenchymal transition (EMT), neoangiogenesis, invasion and metastasis in different types of cancer [ 7 , 8 , 9 , 10 , 11 , 12 ]. The stilbene Resveratrol (RES) (3,5,4′-trihydroxy-trans-stilbene) is found in grapes, berries, peanuts, plums and pine nuts, as cis, trans isomers or conjugated derivatives [ 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival

Focaccetti,

Palumbo,

Benvenuto

et al. 2023

IJMS

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The polyphenols Curcumin (CUR) and Resveratrol (RES) are widely described for their antitumoral effects. However, their low bioavailability is a drawback for their use in therapy. The aim of this study was to explore whether CUR and RES, used at a bioavailable concentration, could modulate immune responses while retaining antitumor activity and to determine whether CUR and RES effects on the immune responses of peripheral blood mononuclear cells (PBMCs) and tumor growth inhibition could be improved by their combination. We demonstrate that the low-dose combination of CUR and RES reduced the survival of cancer cell lines but had no effect on the viability of PBMCs. Although following CUR + RES treatment T lymphocytes showed an enhanced activated state, RES counteracted the increased IFN-γ expression induced by CUR in T cells and the polyphenol combination increased IL-10 production by T regulatory cells. On the other hand, the combined treatment enhanced NK cell activity through the up- and downregulation of activating and inhibitory receptors and increased CD68 expression levels on monocytes/macrophages. Overall, our results indicate that the combination of CUR and RES at low doses differentially shapes immune cells while retaining antitumor activity, support the use of this polyphenol combinations in anticancer therapy and suggest its possible application as adjuvant for NK cell-based immunotherapies.

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