Curcumin Prevents Renal Damage of l‐NAME Induced Hypertension in by Reducing MMP‐2 and MMP‐9
Bruna Pinheiro Pereira,
Alessandra Oliveira Silva,
Wanessa Mayumi Carvalho Awata
et al.
Abstract:In the present study, we investigated whether curcumin administration would interfere with the main renal features of l‐NAME‐induced hypertension model. For this purpose, we conducted both in vitro and in vivo experiments to evaluate renal indicators of inflammation, oxidative stress, and metalloproteinases (MMPs) expression/activity. Hypertension was induced by l‐NAME (70 mg/kg/day), and Wistar rats from both control and hypertensive groups were treated with curcumin (50 or 100 mg/kg/day; gavage) or vehicle f… Show more
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