Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role

Kanitkar, Meghana; Sanjeev, Galande; Bhonde, Ramesh

doi:10.1016/j.ejphar.2007.09.002

Cited by 159 publications

(106 citation statements)

References 43 publications

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“…It is clearly observed that, curcumin give more ameliorating effect. It has been reported the effectiveness of curcumin in reducing secondary complications in STZ induced diabetic animals [11]. Moreover, the curcumin has been demonstrated in prevention isolated betacell death and dysfunction induced by STZ [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…The efficacy of curcumin has been widely observed in reducing various diabetic secondary complications such as diabetic nephropathy/renal lesions retinopathy wound healing and reduction of advanced glycation end products.further studies evaluate the effect of curcumin that could influence pancreatic islets recuperation after the damage induced by STZ. It had been found that in the diabetic mice which were induced by STZ, alkylating agent, DNA was damaged in beta-cell and subsequent inhibition of insulin biosynthesis and secretion [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Curcumin (diferuloylmethane) is a naturally occurring yellow pigment isolated from the rhizomes of the plant Curcuma longa (Linn) found in south Asia and is a potent antioxidant agent and free radical scavenger. Extensive research within the last half a century has proven that, its renowned range of medicinal properties, once associated with turmeric, are due to curcumin, a polyphenolic compound derived from dietary spice turmeric possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, anti proliferative and anti-angiogenic activities [9][10][11][12]. Along with being an inhibitor of lipid peroxidation it is also an inhibitor of Nitric Oxide Syntheses (NOS) over expression and of nuclear factor kappa B activation.…”

Section: Introductionmentioning

confidence: 99%

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Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Waer¹,

Helmy²

2017

J Nutr Food Sci

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Background: Diabetes mellitus is a major endocrine disorder and growing health problem in most countries. Diabetes manifested by experimental animal models exhibit high oxidative stress due to persistent and chronic hyperglycemia which increases the generation of free radicals, Streptozotocin (STZ) provides an animal model of type 1 diabetes. Thereby depleting the activities of antioxidative defense systems with alteration of antioxidant activities of enzymes such as green tea and curcumin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Waer¹,

Helmy²

2017

J Nutr Food Sci

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“…Thereafter, it can be used as a cytoprotective agent for pancreatic islet cells via inhibition of islet apoptosis as it inhibited oxidative stress, more the less, several studies has been investigated the role of curcumin in experimental T2DM. 32,33) Zn supplementation was known by its essential and beneficial role in diabetes. Especially, the Zn levels in pancreatic islets are amongst the highest concentration in the body (about 20 mM).…”

Section: Discussionmentioning

confidence: 99%

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Al-Ali

Fatah

El‐Badry

2016

Biological & Pharmaceutical Bulletin

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Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin-zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin-Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin-Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance.Key words diabetes; curcumin-zinc complex; dual action; curcumin; zinc metal; diabetes complication Diabetes mellitus, the most common endocrine disorder characterized by a state of chronic hyperglycemia and insulin resistance. Type 2 Diabetes Mellitus (T2DM) is projected to rise over 215 million people worldwide by the year 2010.

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“…STZ is a potent methylating agent for DNA and acts as nitric oxide donor in pancreatic cells. β-cells are particularly sensitive to damage by nitric oxide and free radical scavenging enzymes (Lukic et al, 1998;Spinas, 1999;Meghana et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The Wound Healing Effect of Hydnocarpi Semen Extract on Ulcer in Diabetic Mice

Lee¹,

Choi²,

Choi³

et al. 2010

Biomolecules and Therapeutics

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-The extract from Hydnocarpi Semen (HS) has been used to treat leprosy and its anti-inflammatory activity has been reported. However, the effect of HS on the treatment of diabetic or peripheral ulcer is not well known. We therefore examined its wound healing effects on ulcer area in diabetic mice. GC and GC/MS analysis with the total extract of HS show that the main constituents of the extract are chaulmoogric acid, hydnocarpic acid, and gorlic acid. Whereas HS showed wound healing effect in diabetic ulcer, there was no hypoglycemic effect in diabetic mice. The treatment of HS extract significantly decreased the level of total WBC and neutrophils in mice compared to control mice. Cutting ulcer was induced by the round-shaped punch on the backside of diabetic mice and the extract of HS was given orally or topically. The wound area score significantly decreased after treatment of HS at dose of 50 mg/kg. The treatment of HS also induced the activation of macrophages and increased the production of IL-12 and TNF-α in macrophages, indicating that the wound healing by HS extract is associated with the inflammatory effect via the activation of macrophages. Our results suggest that HS extract can be a new therapeutic candidate for treatment of diabetic ulcer.

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Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role

Cited by 159 publications

References 43 publications

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

The Wound Healing Effect of Hydnocarpi Semen Extract on Ulcer in Diabetic Mice

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