Curcumin prevents the structural changes induced in the rats' deep cerebellar nuclei by sodium metabisulfite, a preservative agent

Karimfar, Mohammad Hassan; Noorafshan, Ali; Rashidiani-Rashidabadi, Ali; Poostpasand, Aghdas; Asadi-Golshan, Reza; Abdollahifar, Mohammad‐Amin; Karbalay‐Doust, Saied

doi:10.1016/s1995-7645(14)60250-9

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Sulfite metabolism generates an intermediate product called sulfur trioxide radical that may act in some toxic effects of sulfite, including increment of lipid peroxidation, impairment of DNA synthesis, and destruction of amino acids according to Niknahad and O'Brien (2008). These results partially agreed with Karimfar, et al (2014) who stated that the volume and number of neurons of deep cerebellar nuclei were evaluated in sodium metabisulfite-treated rats. The kidneys showed Proliferation and congestion of the glomerular tuft, the presence of hyaline cast in the lumen of the renal tubules and Periglomerular and intertubular mononuclear leukocyticbinfiltration.…”

Section: Discussionsupporting

confidence: 72%

Pathological study on the effect of some food additives in male albino rats

AL-Sharkawy

Gab-Allah

El-Mashad

et al. 2017

Benha Veterinary Medical Journal

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A B S T R A C TThe histo and clinicopathological effect of MonoSodium Glutamate (food enhancer) and Sodium MetaBisulfite (food preservatives) on different tissues and organs of male Albino rats were investigated. Eighty male Albino rats (150-180 gm) were divided into 5 groups: control group and 4 groups administrated 30 and 60 mg MSG /kg b.wt; 260 and 520 mg SMB /kg b.wt for 12 weeks per os. Rats were sacrificed at 2, 4, 8 and 12 weeks from beginning the experiment. Significant decrease in Hb concentration, PCV, MCV and MCH; and significant increase in RBCs, leukogram, platelet counts, GPT, GOT, BUN, creatinine and total protein were observed in rats administred 30 and 60 mg MSG /kg b.wt. Histopathologically, mild changes were observed in liver, kidney, heart, stomach and intestine. Multifocally, marked degenerative and necrotic changes were seen in the lining epithelium of the seminiferous tubules and neurons particularly in high doses after 8 and 12 weeks post MSG administration. On the other hand, administration of SMB by a dose 260 and 520 mg/kg b.wt resulted in significant increase in Hb, MCH, MCHC, Platelets, total leukocytic counts, GPT, GOT, albumin, BUN and creatinine values. Microscopically, hyperplasia of the biliary epithelium, lymphoid depletion of white pulpe of the spleen and mild degenerative changes in the lining epithelium of the seminiferous tubules, neurons and cardiac muscle were detected. Moderate changes were seen in the renal tissue characterized by degenerative changes in the endothelial cells of glomeruli and renal tubular epithelium with desquamation of the lining epithelial cells and presence of hyaline casts in the lumen. Multifocally, necrotic gastroenteritis with heavy leukocytic infiltration in the lamina propria of the stomach and intestine. In conclusion, the addition of MSG resulted in marked changes in brain and testes while, SMB lead to marked changes in gastrointestinal tract and brain. These changes are dose and time independent in MSG and dose independent only in SMB.

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Section: Discussionsupporting

confidence: 72%

Pathological study on the effect of some food additives in male albino rats

AL-Sharkawy

Gab-Allah

El-Mashad

et al. 2017

Benha Veterinary Medical Journal

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“…In the same manner, curcumin‐loaded lipid nanoparticles revealed a higher ameliorative effect than free curcumin in reversing the pathological alterations induced by aluminum chloride in mice brain section (Kakkar & Kaur, 2011 ). In addition, several studies on curcumin and curcumin‐loaded nanoparticles have reported the combined antioxidant and anti‐inflammatory roles of free curcumin and nanoencapsulated curcumin using different nanoparticles in neurodegenerative diseases (Huang et al, 2017 ; Karimfar et al, 2014 ; Li et al, 2016 ; Noorafshan et al, 2013 ; Partadiredja et al, 2013 ; Sandhir et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Curcumin‐loaded cockle shell‐derived calcium carbonate nanoparticles ameliorates lead‐induced neurotoxicity in rats via attenuation of oxidative stress

Mailafiya

Abubakar

Chiroma

et al. 2022

Food Science & Nutrition

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A substantial global health burden is associated with neurotoxicity caused by lead (Pb) exposure and the common mechanism of this toxicity is mainly via oxidative damage. Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability when orally administered. Currently, cockle shell‐derived calcium carbonate nanoparticle (CSCaCO 3 NP) is gaining more acceptance in nanomedicine as a nanocarrier to various therapeutics. This study aimed at investigating the ameliorative effect of curcumin‐loaded CSCaCO 3 NP (Cur‐CSCaCO 3 NP) on lead‐induced neurotoxicity in rats. A total of 36 male Sprague–Dawley rats were randomly assigned into five groups. Each group consists of 6 rats apart from the control group which consists of 12 rats. During the 4 weeks induction phase, all rats received a flat dose of 50 mg/kg of lead while the control group received normal saline. The treatment phase lasted for 4 weeks, and all rats received various doses of treatments as follows: group C (Cur 100) received 100 mg/kg of curcumin, group D (Cur‐CSCaCO 3 NP 50) received 50 mg/kg of Cur‐CSCaCO 3 NP, and group E (Cur‐CSCaCO 3 NP 100) received 100 mg/kg of Cur‐CSCaCO 3 NP. The motor function test was carried out using the horizontal bar method. The cerebral and cerebellar oxidative biomarker levels were estimated using ELISA and enzyme assay kits. Lead‐administered rats revealed a significant decrease in motor scores and SOD activities with a resultant increase in MDA levels. Furthermore, marked cellular death of the cerebral and cerebellar cortex was observed. Conversely, treatment with Cur‐CSCaCO 3 NP demonstrated enhanced ameliorative effects when compared with free curcumin treatment by significantly reversing the aforementioned alterations caused by lead. Thus, CSCaCO 3 NP enhanced the efficacy of curcumin by ameliorating the lead‐induced neurotoxicity via enhanced attenuation of oxidative stress.

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“…Neurotoxic effects (decrease in volume of deep cerebellar nuclei and number of neurons) were seen after oral sodium metabisulfite administration at 25 mg/kg bw per day (corresponding to 17 mg SO 2 equivalents/kg bw per day) for 56 days in the study by Karimfar et al. (2014). It is noted that these effects were abrogated by concomitant dosing with an antioxidant, curcumin.…”

Section: Appendix B – Summary Of Toxicity Studies Considered Sufficie...mentioning

confidence: 99%

“…From the oral studies of Karimfar et al. (2014) and Noorafshan et al. (2015), the Panel noted that there were effects at 17 mg SO 2 equivalents/kg bw per day on neurons, glia and synaptic plasticity.…”

Section: Assessmentmentioning

confidence: 99%

Follow‐up of the re‐evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228)

Younes¹,

Aquilina²,

Castle³

et al. 2022

EFS2

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Sulfur dioxide–sulfites (E 220–228) were re‐evaluated in 2016, resulting in the setting of a temporary ADI of 0.7 mg SO2 equivalents/kg bw per day. Following a European Commission call for data, the present follow‐up opinion assesses data provided by interested business operators (IBOs) and additional evidence identified in the publicly available literature. No new biological or toxicological data addressing the data gaps described in the re‐evaluation were submitted by IBOs. Taking into account data identified from the literature search, the Panel concluded that there was no substantial reduction in the uncertainties previously identified in the re‐evaluation. Therefore, the Panel considered that the available toxicity database was inadequate to derive an ADI and withdrew the current temporary group acceptable daily intake (ADI). A margin of exposure (MOE) approach was considered appropriate to assess the risk for these food additives. A lower confidence limit of the benchmark dose of 38 mg SO2 equivalents/kg bw per day, which is lower than the previous reference point of 70 mg SO2 equivalents/kg bw per day, was estimated based on prolonged visual evoked potential latency. An assessment factor of 80 was applied for the assessment of the MoE. At the estimated dietary exposures, when using a refined exposure scenario (Data set D), MOEs at the maximum of 95th percentile ranges were below 80 for all population groups except for adolescents. The dietary exposures estimated using the maximum permitted levels would result in MOEs below 80 in all population groups at the maximum of the ranges of the mean, and for most of the population groups at both minimum and maximum of the ranges at the 95th percentile. The Panel concluded that this raises a safety concern for both dietary exposure scenarios. The Panel also performed a risk assessment for toxic elements present in sulfur dioxide–sulfites (E 220–228), based on data submitted by IBOs, and concluded that the maximum limits in the EU specifications for arsenic, lead and mercury should be lowered and a maximum limit for cadmium should be introduced.

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Curcumin prevents the structural changes induced in the rats' deep cerebellar nuclei by sodium metabisulfite, a preservative agent

Abstract: Curcumin, the main part of the turmeric, could prevent the structural changes induced in the deep cerebellar nuclei by sodium metabisulfite, a preservative agent, in rats.

Cited by 7 publications

References 26 publications

Pathological study on the effect of some food additives in male albino rats

Pathological study on the effect of some food additives in male albino rats

Curcumin‐loaded cockle shell‐derived calcium carbonate nanoparticles ameliorates lead‐induced neurotoxicity in rats via attenuation of oxidative stress

Follow‐up of the re‐evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228)

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