Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress

Zeng, Yi; Du, Qingdi; Zhang, Zhiwei; Ma, Jing; Han, Le; Wang, Yuanyuan; Yang, Linpu; Ning, Tao; Qin, Zhihai

doi:10.1016/j.abb.2020.108613

Cited by 44 publications

(23 citation statements)

References 48 publications

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“…Zeng et al found that curcumin induces endoplasmic reticulum stress, loss of mitochondrial potential, cell cycle arrest at the G2−M transition, and apoptosis in prostate CAFs. The sensitivity of natural fibroblasts was approximately three times lower than that in treated CAFs [253]. Ba et al reported that a sublethal curcumin dose (10 µM) decreased the expression of α-SMA, MMP-2, SDF-1, and TGF-β1, and Smad2/3 phosphorylation/activation by approximately half [173].…”

Section: Effect Of Curcumin and Flavonoid Applications On Emt And Metastasis Formationmentioning

confidence: 99%

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

et al. 2021

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Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in some cases with high metastatic activity and high levels of circulating tumour cells (CTCs), the efficacy of standard treatment methods is insufficient and results in treatment failure and reduced patient survival. CTCs are seen not only as an isolated phenomenon but also a key inherent part of the formation of metastasis and a key factor in cancer death. This review discusses the impact of NSCLC therapy strategies based on a meta-analysis of clinical studies. In addition, possible therapeutic strategies for repression when standard methods fail, such as the administration of low-toxicity natural anticancer agents targeting these phenomena (curcumin and flavonoids), are also discussed. These strategies are presented in the context of key mechanisms of tumour biology with a strong influence on CTC spread and metastasis (mechanisms related to tumour-associated and -infiltrating cells, epithelial–mesenchymal transition, and migration of cancer cells).

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Section: Effect Of Curcumin and Flavonoid Applications On Emt And Metastasis Formationmentioning

confidence: 99%

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

et al. 2021

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“…After that, proteins related to DNA reparation, like DNA-dependent protein kinase are activated to act in favor of the DNA damage response pathway [ 27 ]. Curcumin can induce ROS generation and suppress DNA repair machinery, thus leading to increased radiation-induced cell death [ 28 , 29 ].…”

Section: Radiosensitization By Curcuminmentioning

confidence: 99%

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

et al. 2022

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Radiation therapy plays an important role in almost every cancer treatment. However, radiation toxicity to normal tissues, mainly due to the generation of reactive free radicals, has limited the efficacy of radiotherapy in clinical practice. Curcumin has been reported to possess significant antitumor properties. Although curcumin can sensitize cancer cells to irradiation, healthy cells are much less sensitive to this effect, and thus, curcumin is thought to be a potent, yet safe anti-cancer agent. In this review, a summary of the role of curcumin as both a radiosensitizer and radioprotector has been presented, based on the most recent data from the experimental and clinical evaluation of curcumin in different cancer cell lines, animal models, and human patients.

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“…On prostate-CAFs, curcumin can increase the intracellular ROS levels and induce G2/M arrest [ 132 ], while in tongue squamous cell carcinoma, curcumin has been found to inhibit the secretion of pro-carcinogenic cytokines, including stromal cell-derived factor-1 (SDF-1) and matrix metalloproteinases 2 (MMP2) [ 133 ].…”

Section: Curcumin and Cancer-associated Fibroblasts/tumor-associated Fibroblasts (Cafs/tafs)mentioning

confidence: 99%

The Role of Curcumin in Cancer Treatment

et al. 2021

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Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, Curcuma longa which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated with the development of cancer. Curcumin acts on the regulation of various immune modulators, including cytokines, cyclooxygenase-2 (COX-2), and reactive oxygen species (ROS), which partly explains its anticancer effects. It also takes part in the downregulation of growth factors, protein kinases, oncogenic molecules and various signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (STAT3) signaling. Clinical trials of curcumin have been completed or are ongoing for various types of cancer. This review presents the molecular mechanisms of curcumin in different types of cancer and the evidence from the most recent clinical trials.

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Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress

Cited by 44 publications

References 48 publications

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

The Role of Curcumin in Cancer Treatment

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