Curcumin protects against cerebral ischemia-reperfusion injury in rats by attenuating oxidative stress and inflammation: A meta-analysis and mechanism exploration

Yang, Xuyi; Xu, Liang; Zhao, Hui; Xie, Tinghui; Wang, Jiabing; Wang, Lei; Yang, Jun

doi:10.1016/j.nutres.2023.02.009

Cited by 7 publications

(2 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resveratrol has demonstrated therapeutic potential in rats by decreasing oxidative stress markers and showing improvement in neurological function, as well as a decrease in infarct size in a study [182,183]. On the other hand, curcumin has also shown potential benefits in ischemic stroke in rats, reducing neurological deficit score and infarct size, increasing antioxidant enzymes, and decreasing markers of oxidative stress [184]. In a study in rats, quercetin demonstrated a reduction in infarct size and an upregulation of antioxidant status [185].…”

Section: Strokementioning

confidence: 99%

Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

Pinilla-González,

Rojas-Solé,

Gómez-Hevia

et al. 2024

Foods

View full text Add to dashboard Cite

Numerous natural antioxidants commonly found in our daily diet have demonstrated significant benefits for human health and various diseases by counteracting the impact of reactive oxygen and nitrogen species. Their chemical properties enable a range of biological actions, including antihypertensive, antimicrobial, anti-inflammatory, anti-fibrotic, and anticancer effects. Despite promising outcomes from preclinical studies, ongoing debate persists regarding their reproducibility in human clinical models. This controversy largely stems from a lack of understanding of the pharmacokinetic properties of these compounds, coupled with the predominant focus on monotherapies in research, neglecting potential synergistic effects arising from combining different antioxidants. This study aims to provide an updated overview of natural antioxidants, operating under the hypothesis that a multitherapeutic approach surpasses monotherapy in efficacy. Additionally, this study underscores the importance of integrating these antioxidants into the daily diet, as they have the potential to prevent the onset and progression of various diseases. To reinforce this perspective, clinical findings pertaining to the treatment and prevention of non-alcoholic fatty liver disease and conditions associated with ischemia and reperfusion phenomena, including myocardial infarction, postoperative atrial fibrillation, and stroke, are presented as key references.

show abstract

Section: Strokementioning

confidence: 99%

Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

Pinilla-González,

Rojas-Solé,

Gómez-Hevia

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…Curcumin MIRI [67] and CIRI [68] Decrease myocardial apoptosis by activating JAK2/STAT3 pathway, thus reducing OS-damage [67]; while neuroprotection could be due to inhibition of pyroptosis by suppressing the p38 MAPK pathway [69].…”

Section: Natural Antioxidant Bioactive Molecules Against Myocardial I...mentioning

confidence: 99%

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Orellana-Urzúa,

Briones-Valdivieso,

Chichiarelli

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Stroke and acute myocardial infarction are leading causes of mortality worldwide. The latter accounts for approximately 9 million deaths annually. In turn, ischemic stroke is a significant contributor to adult physical disability globally. While reperfusion is crucial for tissue recovery, it can paradoxically exacerbate damage through oxidative stress (OS), inflammation, and cell death. Therefore, it is imperative to explore diverse approaches aimed at minimizing ischemia/reperfusion injury to enhance clinical outcomes. OS primarily arises from an excessive generation of reactive oxygen species (ROS) and/or decreased endogenous antioxidant potential. Natural antioxidant compounds can counteract the injury mechanisms linked to ROS. While promising preclinical results, based on monotherapies, account for protective effects against tissue injury by ROS, translating these models into human applications has yielded controversial evidence. However, since the wide spectrum of antioxidants having diverse chemical characteristics offers varied biological actions on cell signaling pathways, multitherapy has emerged as a valuable therapeutic resource. Moreover, the combination of antioxidants in multitherapy holds significant potential for synergistic effects. This study was designed with the aim of providing an updated overview of natural antioxidants suitable for preventing myocardial and cerebral ischemia/reperfusion injuries.

show abstract

A network pharmacology-based study to investigate the mechanism of curcumin-regulated regenerative repair of quadriceps femoris muscle in KOA rats

Ye,

Li,

Yang

et al. 2024

European Journal of Pharmacology

View full text Add to dashboard Cite

Curcumin protects against cerebral ischemia-reperfusion injury in rats by attenuating oxidative stress and inflammation: A meta-analysis and mechanism exploration

Cited by 7 publications

References 68 publications

Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

A network pharmacology-based study to investigate the mechanism of curcumin-regulated regenerative repair of quadriceps femoris muscle in KOA rats

Contact Info

Product

Resources

About