Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

Zeng, Chunlai; Zhong, Peng; Zhao, Yunjie; Kanchana, Karvannan; Zhang, Yali; Khan, Zia A.; Chakrabarti, Subrata; Wu, Lianpin; Wang, Jingying; Liang, Guang

doi:10.1016/j.yjmcc.2014.10.002

Cited by 155 publications

(97 citation statements)

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“…An increase in body weight has been directly associated with an increased risk in developing chronic disorders, such as hypertension, hyperlipidemia, diabetes mellitus, and cardiovascular disease (Mathieu et al, 2010;Gregor and Hotamisligil, 2011;Zeng et al, 2015). All of these can promote chronic kidney disease (CKD) and-as the prevalence of obesity is rapidly increasing-the incidence of obesity-related glomerulopathy (ORG) in obese patients has also been on the rise in the population (Kambham et al, 2001;Bello et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…PA, which is also the most common FFA found in animals (Gunstone et al, 1994), has also been implicated in the pathogenesis of glomerulopathy and tubulointerstitial lesions in type 2 diabetes (Nosadini and Tonolo, 2011). It has also been demonstrated both in vitro and in vivo that FFAs can activate both the nuclear factor (NF)-kB and mitogen-activated protein kinase (MAPK) pathways, subsequently increasing the expression of proinflammatory cytokines, such as tumor necrosis factor (TNF) a, interleukin (IL) b, IL-1b, and interferon (IFN) g as well as proadhesion genes, such as intercellular cell adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) (Yamagishi et al, 2002;Boden et al, 2005;Bost et al, 2005;Nguyen et al, 2006;Zeng et al, 2015). Furthermore, there is also increasing evidence suggesting that chronically elevated FFA levels in obese individuals were responsible for the systemic inflammation observed in CKD, and the accumulation of lipids in nonadipose tissue is associated with structural and functional changes of various kidney cells, which also contributes to the development of obesity-induced renal disease (de Vries et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Fang

Deng

Wang

et al. 2015

J Pharmacol Exp Ther

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The prevalence of obesity has increased dramatically worldwide leading to increases in obesity-related complications, such as obesity-related glomerulopathy (ORG). Obesity is a state of chronic, low-grade inflammation, and increased inflammation in the adipose and kidney tissues has been shown to promote the progression of renal damage in obesity. Current therapeutic options for ORG are fairly limited and, as a result, we are seeing increased rates of progression to end-stage renal disease. Chalcones are a class of naturally occurring compounds with various pharmacological properties. 1-(3,4-Dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one (L2H17) is a chalcone that we have previously synthesized and found capable of inhibiting the lipopolysaccharide-induced inflammatory response in macrophages. In this study, we investigated L2H17's effect on obesityinduced renal injury using palmitic acid-induced mouse peritoneal macrophages and high fat diet-fed mice. Our results indicate that L2H17 protects against renal injury through the inhibition of the mitogen-activated protein kinase/ nuclear factor kB pathways significantly by decreasing the expression of proinflammatory cytokines and cell adhesion molecules and improving kidney histology and pathology. These findings lead us to believe that L2H17, as an antiinflammatory agent, can be a potential therapeutic option in treating ORG.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Fang

Deng

Wang

et al. 2015

J Pharmacol Exp Ther

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“…For example, in India, it was rubbed on infectious wounds and healed it by destroying the bacterial wounds. In new medicine, turmeric, anti-bacterial, antifungal, antimicrobial and antiviral effects have been reported [21]. For example, its alcoholic extract was effective on gram-positive bacterium in vitro.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection

Ranjbar¹,

Mohammadi²

2018

biomedicalresearch

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“…Curcumin has been demonstrated to possess a wide range of pharmaceutical activities, such as anti-tumor [3,4], antiinflammation [5], anti-oxidation [6], anti-bacterial [7], and cardiovascular protection [8,9]. However, its high metabolic instability and low bioavailability have dramatically limited its practical application [10].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 2,5-bis((E)-2-(trifluoromethyl)benzylidene)cyclopentan-1-one, C₂₁H₁₄F₆O

Zhang

Qiu

et al. 2017

Zeitschrift Für Kristallographie - New Crystal Structures

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CCDC no.: 1569702The crystal structure is shown in the figure. Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of materialsThe title compound was synthesized by Aldol condensation between two molecules of 2-(trifluoromethyl)benzaldehyde and cyclopentanone, which was synthesized according our earlier published method [1,2]. In detail: 5.0 mmol cyclopentanone was added to a solution of 10 mmol 2-(trifluoromethyl)benzaldehyde in MeOH (10 mL). The solution was stirred at room temperature for 30 min, followed by dropwise addition of NaOCH 3 /CH 3 OH (1.0 mL, 5.0 mmol). The mixture was stirred at room temperature and monitored with TLC. When the reaction was finished, the residue was poured into saturated NH 4 Cl solution and filtered. The precipitate was washed with water and cold ethanol, and dried in vacuum. The solid was further purified by silica gel chromatography (CH 2 Cl 2 /CH 3 OH). All chemicals used for the synthesis were commercially available and were used without further purification. The yellow crystals of the title compound were obtained by slow evaporation of a CH 3 OH solution at room temperature. Experimental detailsPosition of the H atoms were calculated based on geometric criteria (C-H = 0.97 and 0.93 for methyl and aromatic atoms, respectively) and placed in their calculated position and refined, using a riding model with U iso (H) = 1.5 U eq (C) for methyl and U iso (H) = 1.2 U eq (C) for all others. DiscussionCurcumin has been demonstrated to possess a wide range of pharmaceutical activities, such as anti-tumor [3,4], antiinflammation [5], anti-oxidation [6], anti-bacterial [7], and cardiovascular protection [8,9]. However, its high metabolic instability and low bioavailability have dramatically limited its practical application [10]. Recently, our research group has synthesized a series of mono-carbonyl analogs of curcumin (MACs) by deleting β-diketone moiety [11,12]. The title compound is an Curcumin analogon with one central keto group only.

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Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

Cited by 155 publications

References 51 publications

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection

Crystal structure of 2,5-bis((E)-2-(trifluoromethyl)benzylidene)cyclopentan-1-one, C₂₁H₁₄F₆O

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Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

Cited by 155 publications

References 51 publications

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor κB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice

Synergistic effects of combined curcumin and antibiotic in ameliorating an animal model of Helicobacter pylori infection

Crystal structure of 2,5-bis((E)-2-(trifluoromethyl)benzylidene)cyclopentan-1-one, C21H14F6O

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Crystal structure of 2,5-bis((E)-2-(trifluoromethyl)benzylidene)cyclopentan-1-one, C₂₁H₁₄F₆O