Curcumin protects thymus against D-galactose-induced senescence in mice

Li, Jie-Han; Wei, Tingting; Guo, Li; Cao, Jiahui; Feng, Yuan‐kang; Guo, Shu-Ning; Liu, Guo-Hong; Ding, Yi; Chai, Yurong

doi:10.1007/s00210-020-01945-8

Cited by 12 publications

(4 citation statements)

References 58 publications

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“…Thymus is the main immune organ of the body, and calculation of thymus index can reflect the immune status to a certain extent (44) . In this study, the thymus index of the rats in group M was significantly lower than that in group N, indicating that D-galactose could cause degenerative changes in the thymus of the ageing model rats, which was consistent with the literature reports (45,46) . According to the experimental data, the thymus index of groups FM and FH was notably higher than that of group M. It can be seen that a certain dose of FE can delay the ageing-induced thymic atrophy and exert a certain protective effect on the decline of immune function.…”

Section: Discussionsupporting

confidence: 93%

Peanut meal extract fermented with Bacillus natto attenuates physiological and behavioural deficits in a d-galactose-induced ageing rat model

Ding

Liu

et al. 2021

Br J Nutr

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Our previous studies have shown that the nutritional properties of peanut meal after fermentation are markedly improved. In this study, in order to facilitate the further utilization of peanut meal, we investigated the effects of its fermentation extract by Bacillus natto (FE) on cognitive ability, antioxidant activity of brain, and protein expression of hippocampus of aging rats induced by D-galactose. Seventy-two female SD rats aged 4-5 months were randomly divided into six groups: normal control group (N), aging model group (M), FE low-dose group (FL), FE medium-dose group (FM), FE high-dose group (FH) and vitamin E positive control group (Y). Morris water maze (MWM) test was performed to evaluate their effects on learning and memory ability in aging rats. SOD activity and malondialdehyde (MDA) content of brain, HE staining and the expression of γ-aminobutyric acid receptor 1 (GABABR1) and N-methyl-D-aspartic acid 2B receptor (NMDAR2B) in the hippocampus of rats were measured. The results show that FE supplementation can effectively alleviate the decrease of thymus index induced by aging, decrease the escape latency of MWM by 66.06%, brain MDA by 28.04%, hippocampus GABABR1 expression by 7.98%, and increase brain SOD by 63.54% in aging model rats. This study provides evidence for its anti-aging effects and is a research basis for potential nutritional benefits of underutilized food by-products.

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Section: Discussionsupporting

confidence: 93%

Peanut meal extract fermented with Bacillus natto attenuates physiological and behavioural deficits in a d-galactose-induced ageing rat model

Ding

Liu

et al. 2021

Br J Nutr

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“…Curcumin targets senescent cells for clearing. The senolytic capacity of curcumin has been demonstrated in a variety of contexts and cell types ( 136 , 139 , 140 ). Additionally, the curcumin analog, EF24, is a strong senolytic that induces apoptosis of senescent cells through Bal-2 proteasome degradation, independent of producing ROS ( 141 ).…”

Section: Senolytic and Senomorphic Secondary Metabolites In ...mentioning

confidence: 99%

Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease

Miller,

Darji,

Walaieh

et al. 2023

Front. Neurol.

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Drosophila melanogaster is a valuable model organism for a wide range of biological exploration. The well-known advantages of D. melanogaster include its relatively simple biology, the ease with which it is genetically modified, the relatively low financial and time costs associated with their short gestation and life cycles, and the large number of offspring they produce per generation. D. melanogaster has facilitated the discovery of many significant insights into the pathology of Parkinson’s disease (PD) and has served as an excellent preclinical model of PD-related therapeutic discovery. In this review, we provide an overview of the major D. melanogaster models of PD, each of which provide unique insights into PD-relevant pathology and therapeutic targets. These models are discussed in the context of their past, current, and future potential use for studying the utility of secondary metabolites as therapeutic agents in PD. Over the last decade, senolytics have garnered an exponential interest in their ability to mitigate a broad spectrum of diseases, including PD. Therefore, an emphasis is placed on the senolytic and senomorphic properties of secondary metabolites. It is expected that D. melanogaster will continue to be critical in the effort to understand and improve treatment of PD, including their involvement in translational studies focused on secondary metabolites.

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“…Another study even reported how long-time CUR therapy may progressively reverse cognitive dysfunction in D-galinduced senescent mice by delaying the aging process and improving cognitive functions and locomotor activity, as well as restoring the mitochondrial enzyme complex function [154]. In a recent study, CUR supplementation rejuvenates senescence-associated changes in thymus among D-galinduced senescent mice through promotion of proliferating cells, preventing cells from apoptosis, and enhancing the transcription of the autoimmune regulator (Aire) [155].…”

Section: Studies Of Cell Senescence: Evidence From Mice Andmentioning

confidence: 99%

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

Bahrami

Montecucco

Carbone

et al. 2021

BioMed Research International

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Aging is characterized by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues throughout the lifespan. Senescence is occurring following enormous intracellular or extracellular stress stimuli. Cellular senescence serves as an antiproliferative process that causes permanent cell cycle arrest and restricts the lifespan. Senescent cells are characterized by terminal cell cycle arrest, enlarged lysosome, and DNA double-strand breaks as well as lipofuscin granularity, senescence-associated heterochromatin foci, and activation of DNA damage response. Curcumin, a hydrophobic polyphenol, is a bioactive chemical constituent of the rhizomes of Curcuma longa Linn (turmeric), which has been extensively used for the alleviation of various human disorders. In addition to its pleiotropic effects, curcumin has been suggested to have antiaging features. In this review, we summarized the therapeutic potential of curcumin in the prevention and delaying of the aging process.

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Curcumin protects thymus against D-galactose-induced senescence in mice

Cited by 12 publications

References 58 publications

Peanut meal extract fermented with Bacillus natto attenuates physiological and behavioural deficits in a d-galactose-induced ageing rat model

Peanut meal extract fermented with Bacillus natto attenuates physiological and behavioural deficits in a d-galactose-induced ageing rat model

Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

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