Curcumin reduces cold storage-induced damage in human cardiac myoblasts

Abuarqoub, Hadil; Green, Colin J.; Foresti, Roberta; Motterlini, Roberto

doi:10.1038/emm.2007.16

Cited by 31 publications

(15 citation statements)

References 24 publications

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“…Both biliverdin and bilirubin possess antioxidant properties (28). Ample evidence supports the notion that up-regulation of heme oxygenase-1 expression provides potent cytoprotective effects in many in vitro and in vivo models of oxidative stress-induced cellular and tissue injury (15,19,(28)(29)(30). Many recent studies have revealed that curcumin potently induces heme oxygenase-1 expression, such as in cardiac myoblasts (29), hepatocytes (30), and monocytes (28), leading to increased resistance to oxidative stress-mediated damage.…”

Section: Discussionmentioning

confidence: 94%

Curcumin attenuates ischemia–reperfusion injury in rat testis

Wei

Zhou

2009

Fertility and Sterility

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Section: Discussionmentioning

confidence: 94%

Curcumin attenuates ischemia–reperfusion injury in rat testis

Wei

Zhou

2009

Fertility and Sterility

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“…2-4). In particular, curcumin increased the expression of HO-1 in human cardiac myoblasts, hepatocytes, monocytes and endothelial cells, rat neurons and astrocytes as well as porcine endothelial cells [34, [146][147][148][149][150]. In rodents and human cells, curcumin-induced HO-1 overexpression was correlated with production of mitochondrial ROS, activation of transcription factors Nrf2 and NF-jB, induction of MAPK p38 and inhibition of phosphatase activity [149,151,152].…”

Section: Natural Antioxidants Vitagenes and Neurodegenerative Disordersmentioning

confidence: 99%

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Calabrese

Cornelius

Mancuso³

et al. 2008

Neurochem Res

256

227

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The predominant molecular symptom of aging is the accumulation of altered gene products. Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox homeostasis and lead to accumulation of unfolded or misfolded proteins in the aging brain. Alzheimer's and Parkinson's diseases or Friedreich ataxia are neurological diseases sharing, as a common denominator, production of abnormal proteins, mitochondrial dysfunction and oxidative stress, which contribute to the pathogenesis of these so called "protein conformational diseases". The central nervous system has evolved the conserved mechanism of unfolded protein response to cope with the accumulation of misfolded proteins. As one of the main intracellular redox systems involved in neuroprotection, the vitagene system is emerging as a neurohormetic potential target for novel cytoprotective interventions. Vitagenes encode for cytoprotective heat shock proteins (Hsp) Hsp70 and heme oxygenase-1, as well as thioredoxin reductase and sirtuins. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Thus, the impact of dietary factors on health and longevity is an increasingly appreciated area of research. Reducing energy intake by controlled caloric restriction or intermittent fasting increases lifespan and protects various tissues against disease. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin, a group of proteins linked to aging, metabolism and stress tolerance in several organisms. Recent findings suggest that several phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of vitagenes encoding survival proteins, as in the case of the Keap1/Nrf2/ARE pathway activated by curcumin and NAD/NADH-sirtuin-1 activated by resveratrol. Consistently, the neuroprotective roles of dietary antioxidants including curcumin, acetyl-L-carnitine and carnosine have been demonstrated through the activation of these redox-sensitive intracellular pathways. Although the notion that stress proteins are neuroprotective is broadly accepted, still much work needs to be done in order to associate neuroprotection with specific pattern of stress responses. In this review the importance of vitagenes in the cellular stress response and the potential use of dietary antioxidants in the prevention and treatment of neurodegenerative disorders is discussed.

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“…Similarly to sulforaphane, in addition to potently inducing cytoprotective proteins, curcumin is a pleiotropic agent with multiple molecular targets and biological activities (reviewed in [96][97][98]). Interestingly, because of its cytoprotective effects (that have been attributed largely to induction of HO-1) against damage induced by cold preservation/warm reperfusion in cultured renal epithelial cells [99], hepatocytes [100], and cardiac myoblasts [101], a potential clinical use of curcumin has been suggested in the processes related to organ storage and transplantation.…”

Section: Michael Acceptors a Prominent Class Of Inducers Of Cytoprotmentioning

confidence: 99%

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

Dinkova‐Kostova¹,

Talalay²

2008

Mol. Nutr. Food Res.

355

415

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Cellular protection against oxidative and electrophile toxicities is provided by two types of small-molecule antioxidants: (i) direct antioxidants, which are redox active, short-lived, are sacrificed in the process of their antioxidant actions and need to be replenished or regenerated, and may evoke pro-oxidant effects; and (ii) indirect antioxidants, that may or may not be redox active. Indirect antioxidants activate the Keap1/Nrf2/ARE pathway resulting in transcriptional induction of a battery of cytoprotective proteins (also known as phase 2 enzymes) that act catalytically, are not consumed, have long half-lives, and are unlikely to evoke pro-oxidant effects. These protective systems are involved in a complex functional interplay, such that many cytoprotective proteins participate in the synthesis and/or regeneration of direct antioxidants, whereas some direct antioxidants are required for the catalytic functions of cytoprotective proteins. Importantly, many inducers of cytoprotective proteins have been isolated from edible plants, e. g., sulforaphane from broccoli and curcumin from turmeric. Both are pleiotropic agents with multiple biological activities that could collectively contribute to their protective effects in various animal studies, including models of carcinogenesis, hypertension, neuronal and retinal damage. In addition to inducing cytoprotective proteins, molecules like curcumin which contain Michael acceptor functionalities (olefins or acetylenes conjugated to electron withdrawing groups) and phenolic hydroxyl groups can scavenge directly and potently oxygen- and nitrogen-centered reactive intermediates. Such bifunctional antioxidants can play a dual protective role by: (i) scavenging hazardous oxidants directly and instantaneously, and (ii) inducing cytoprotective enzymes that in turn function to resolve the consequences of hazardous processes that are already in progress, and to ensure long-term protection against subsequent challenges.

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Curcumin reduces cold storage-induced damage in human cardiac myoblasts

Cited by 31 publications

References 24 publications

Curcumin attenuates ischemia–reperfusion injury in rat testis

Curcumin attenuates ischemia–reperfusion injury in rat testis

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

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