Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with A&amp;beta;-induced Alzheimer&amp;#39;s disease: protecting spatial learning and memory

Wang, Yunliang; Li, Jinfeng; Wang, Yu-tong; Xu, Chunyang; Hua, Liang; Yang, Xiaopeng; Geng, Shuang; Wang, Shanshan; Wang, Zhen; Yin, Honglei

doi:10.2147/jn.s125567

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…With the administration of curcumin, these cytokines were downregulated via the JNK/NF-κB/Akt pathway [ 87 , 122 ]. Similarly, Wang et al [ 123 ] showed that curcumin inhibited JNK-3 phosphorylation. Karlstetter et al [ 104 ] inhibited LPS-induced cyclooxygenase-2 (COX-2) by administration of curcumin.…”

Section: Curcuminmentioning

confidence: 95%

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege

2021

Materials

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AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the uses of flavonoids, and one of the most promising is curcumin; however, because it has difficulty permeating the blood–brain barrier (BBB), it must be encapsulated by a drug carrier. Some of the most frequently studied are lipid nanocarriers, liposomes, micelles and PLGA. These carriers are further conjugated with brain-targeting agents such as lactoferrin and transferrin. In this review paper, curcumin and its therapeutic effects, which have been examined in vivo, are analyzed and then the delivery systems to the brain are addressed. Overall, the analysis of the literature revealed great potential for curcumin in treating AD and indicated the challenges that require further research.

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Section: Curcuminmentioning

confidence: 95%

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege

2021

Materials

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“…The toxicity of the amyloid-β peptide damages spatial learning and memory through the c-Jun N-terminal kinase (JNK) signaling pathway in AD. After treating with curcumin, AD rats show restored spatial learning and memory deficits, and JNK-3 phosphorylation is inhibited [ 141 ]. In mice with AD, active avoidance and locomotor activity are improved by curcumin, which protects against neurodegeneration [ 142 ].…”

Section: Health Benefits Of Curcuminmentioning

confidence: 99%

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

et al. 2018

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Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.

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“…Curcumin was shown to affect protein kinase modulation, such as Akt [ 32 ], JNK [ 33 ], and GSK-3β [ 34 ]. Since protein kinase has a crucial role in protein tau phosphorylation, it may explain why tau protein level was significantly decreased in both treatment group.…”

Section: Discussionmentioning

confidence: 99%

Turmeric Extract Supplementation Reduces Tau Protein Level in Repetitive Traumatic Brain Injury Model

Siahaan¹,

Japardi²,

Rambe³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Repetitive traumatic brain injury (RTBI) has gained much attention in this decade, especially in contact sports athletes and military personals. This injury is correlated with early neurodegenerative changes that are marked with the increased of tau protein. Turmeric extract (TE) is a well-known anti-inflammation and antioxidant that decreases tau protein expression in neurodegenerative disease.AIM:This study aimed to prove the effect of TE on tau protein level after RTBI.METHODS:Forty Sprague Dawley mice were divided into four groups, i.e. negative sham control group, the control group, and two treatment groups. A weight drop model was used by applying a 40-gram mass that was dropped from a 1-meter height onto the vertex of the head, with a total frequency of 12 times, divided into 4 days (day 0, 1, 3, and 7; 3 traumas on each day). TE was given to all treatment groups with 500 mg/kg BW doses once daily. The first treatment group had TE for seven days along the trauma. The second treatment group had pretreatment TE extract, given from seven days before first trauma and continued along the trauma protocol days. Tau protein level was measured on brain and serum using ELISA method.RESULTS:There was a significant reduction of tau protein level in both treatment groups compared to trauma group, either in serum or brain, but we also found significant differences regarding brain tau level between the treatment and pretreatment group.CONCLUSION:This study might provide evidence of with the role of pretreatment TE in RTBI.

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Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory

Cited by 12 publications

References 34 publications

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Turmeric Extract Supplementation Reduces Tau Protein Level in Repetitive Traumatic Brain Injury Model

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