Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

Huang, Zhen; Zhang, Xiaoming; Li, Zhao-Yi; Feng, Chun-Rong; Pan, Ai-Juan; Mao, Qing-Qiu

doi:10.1016/j.neulet.2011.02.030

Cited by 119 publications

(71 citation statements)

References 30 publications

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“…In addition, it has been shown that corticosterone treatment caused a significant decrease in BDNF protein and mRNA expression in rat brain, while antidepressants treatment significantly increased BDNF expression in corticosterone-treated rats (Dwivedi et al 2006;Huang et al 2011). Previous in vitro studies have also demonstrated that corticosterone treatment significantly decrease BDNF mRNA expression in the primary cultured hippocampal neurons as well as PC12 cells, which could be reversed by antidepressants (Li et al 2007b;Zheng et al 2011).…”

Section: Discussionmentioning

confidence: 97%

Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells

Mao

Huang

et al. 2011

Cell Mol Neurobiol

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Hyperactivation of the hypothalamic-pituitary-adrenal axis and the associated hippocampal atrophy were observed in patients with depression, which could be ameliorated by the treatment with antidepressants. Therefore, neuroprotection has been proposed to be one of the acting mechanisms of antidepressant. Our previous studies have showed that treating mice with piperine produced antidepressant-like effect in animal models of behavioral despair. This study aimed to examine the protective effect of piperine treatment on corticosterone-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells. The results showed that piperine co-treatment revealed a differential effect on the cytotoxicity of corticosterone and had its maximum inhibitory effect at 1 μM. Piperine (1 μM) co-treatment also significantly decreased intracellular reactive oxygen species level, and enhanced superoxide dismutase activity and total glutathione level in corticosterone-treated PC12 cells. In addition, piperine (1 μM) co-treatment was found to reverse the decreased brain-derived neurotrophic factor (BDNF) mRNA level caused by corticosterone in PC12 cells. The results suggest that piperine exerts a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, at least in part, via the inhibition of oxidative stress and the upregulation of BDNF mRNA expression. This neuroprotective effect may be one of the acting mechanisms accounts for the in vivo antidepressant activity of piperine.

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Section: Discussionmentioning

confidence: 97%

Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells

Mao

Huang

et al. 2011

Cell Mol Neurobiol

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“…In fact, the model of depression induced by chronic administration of CORT induces behavioral alterations that resemble depression (Zhao et al, 2008). Studies show that animals submitted to this model present a depressive-like phenotype as observed by the increases in immobility time in the FST and tail suspension test (TST), anxiety-like phenotype as observed by decrease in the open arms entries in the plus maze test and anhedonic-like phenotype represented by reduce in sucrose consumption in SPT (Zhao et al, 2008;Huang et al, 2011;Silva et al, 2013), corroborating with data of current study.…”

Section: Discussionmentioning

confidence: 99%

Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression

Sousa

Meneses

Vasconcelos

et al. 2015

Psychiatry Research

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Brain derived neurotrophic factor (BDNF) is linked to the pathophysiology of depression. We hypothesized that BDNF is one of the neurobiological pathways related to the augmentation effect of alpha-lipoic acid (ALA) when associated with antidepressants. Female mice were administered vehicle or CORT 20mg/kg during 14 days. From the 15th to 21st days the animals were divided in groups that were further administered: vehicle, desvenlafaxine (DVS) 10 or 20mg/kg, ALA 100 or 200mg/kg or the combinations of DVS10+ALA100, DVS20+ALA100, DVS10+ALA200 or DVS20+ALA200. ALA or DVS alone or in combination reversed CORT-induced increase in immobility time in the forced swimming test and decrease in sucrose preference, presenting, thus, an antidepressant-like effect. DVS10 alone reversed CORT-induced decrease in BDNF in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The same was observed in the HC and ST of ALA200 treated animals. The combination of DVS and ALA200 reversed CORT-induced alterations in BDNF and even, in some cases, increased the levels of this neurotrophin when compared to vehicle-treated animals in HC and ST. Taken together, these results suggest that the combination of the DVS+ALA may be valuable for treating conditions in which BDNF levels are decreased, such as depression.

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“…These have consistently demonstrated that both acute (Arora et al, 2011;Chimakurthy and Talasila, 2010;Gilhotra and Dhingra, Antidepressant Potential Modes of Action of Curcumin 2010; Kulkarni et al, 2008;Sanmukhani et al, 2011;Wang et al, 2008) and chronic (Bhutani et al, 2009;Huang et al, 2011;Li et al, 2009;Sanmukhani et al, 2011;Xia et al, 2007;Xu et al, 2005b) administration of curcumin to rats and mice reduces immobility time.…”

Section: Antidepressant Effects Of Curcumin In Animal Modelsmentioning

confidence: 95%

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

2012

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Curcumin is the principal curcuminoid of the popular Indian spice turmeric and has attracted increasing attention for the treatment of a range of conditions. Research into its potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. Research completed to date on the multiple effects of curcumin is reviewed in this paper, with a specific emphasis on the biological systems that are compromised in depression. The antidepressant effects of curcumin in animal models of depression are summarised, and its influence on neurotransmitters such as serotonin and dopamine is detailed. The effects of curcumin in moderating hypothalamus-pituitary-adrenal (HPA) disturbances, lowering inflammation, and protecting against oxidative stress, mitochondrial damage, neuroprogression and intestinal hyperpermeability, all of which are compromised in major depressive disorder, are also summarised. With increasing interest in natural treatments for depression, and efforts to enhance current treatment outcomes, curcumin is presented as a promising novel, adjunctive or stand-alone natural antidepressant.

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Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

Cited by 119 publications

References 30 publications

Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells

Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells

Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

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