Curcumin Reverses the Diazepam‐Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF‐κB Pathway in Brain

Abstract

Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK/NF-κB signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam-treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP. CUR (150 mg/kg b.w.) was orally administered for 28 days. DZP (2 mg/kg b.w.) was intraperitoneally administered 20 minutes before the behavioral tests (open field test, Y-maze, and elevated plus maze). CUR improved the spontaneous alternation behavior, decreased the oxidative stress levels, both in the blood and in the hippocampus, and downregulated the extracellular signal-regulated kinase (ERK 1/2)/nuclear transcription factor- (NF-) κB/pNF-κB pathway in the hippocampus and the iNOS expression in the hippocampus and frontal lobe of the DZP-treated rats. Histopathologically, no microscopic changes were found. The immunohistochemical signal of iNOS decreased in the DZP and CUR-treated group. Thus, our findings suggest that curcumin administration may improve the cognitive performance and may also have an antioxidant effect.

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

“…Curcumin longa, commonly referred as turmeric, is used widespread as an essential spice in food preparations mainly due to its medicinal properties. Curcumin exhibits a number of medicinal properties including anti-diabetic [1], anti-arthritic [2], anti-oxidant [3], anti-inflammatory [4], antimicrobial [5], anti-neurodegenerative [6]and anticancer [7]. Despite the widespread applications, the beneficial effects of curcumin are hampered by its poor bioavailability which results from its high metabolic and excretion rates, poor absorption and minimal water insolubility [8].…”

Nicotinate‐curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus

“…Accumulating evidences have confirmed that DM is a major pathogenesis factor for cognitive deficits . Curcumin has been shown to be an effective agent for attenuating diabetic encephalopathy and improving surgery‐induced cognitive dysfunction in mice . In this study, we first explored the effects of the curcumin derivative NC on learning and memory performances of rats with DM induced by STZ.…”

“…4,5,26 Curcumin has been shown to be an effective agent for attenuating diabetic encephalopathy and improving surgery-induced cognitive dysfunction in mice . 17,18,27 In this study, we first explored the effects of the curcumin derivative NC on learning and memory performances of rats with DM induced by STZ. Our results revealed that the declined cognitive functions in DM rats were significantly reserved by NC treatment, as evidenced by decreases in escape latency as well as increases in times across target quadrant in MWM test, and elevated DI in the novel object recognition test.…”

“…[13][14][15] Curcumin, a major bioactive component of turmeric, can prevent cognitive impairment via its various pharmacological activities including regulation of autophagy, anti-oxidative stress, and anti-inflammation. [16][17][18] However, the poor aqueous solubility and relatively low bioavailability of curcumin limits its utilization. To overcome those limitations, a series of curcumin derivatives have been developed.…”

Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders

“…These results have suggested that curcumin might be a potential therapeutic agent for preventing protein aggregation in Alzheimer's, and Parkinson's diseases [40]. Recent in vitro and in vivo investigations of curcumin's activities in neurodegenerative disease models [41][42][43][44][45][46][47][48][49][50] are summarized in Table 2. [47].…”