Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Abstract

The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

“…[72]. Among the phytochemicals studied, a special attention has been paid on phenolic compounds from a variety of sources [73,74], such as tea [75,76], grapes [77], ginseng [78], red to purple colour fruits [79][80][81], cruciferous vegetables [82,83], etc. Several bioactive compounds found in oils, such as tocopherols and tocotrienols, phenolic acids, flavonoids, and sterols have anti-obesity effects [84].…”

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

“…A number of secondary metabolites are credited with the ability to prevent aggregation of Aβ and reduce Aβ burden in experimental models of AD: the flavonoids apigenin [44], baicalein [45], hesperidin, isoquercetin, morin [46], narirutin [47] and quercetin [48]; the alkaloid berberine found in plants from the genus Berberis [49]; the carotenoid curcumin from Curcuma longa [50]; the catechin epigallocatechin gallate (EGCG) present in tea (Camellia sinensis) [51,52]; the stilbenoid resveratrol which is found primarily in grape skin and wine [53]; the monoterpene linalool, a major constituent in the essential oils (EOs) of a number of aromatic species such as lavender, rosemary and lemon balm [54]; withanolides from Withania somnifera, a medicinal plant also known as 'Ashwadhanda' in Ayurvedic medicine [44]. Curcumin also destabilizes Aβ aggregates and promotes disaggregation of existing Aβ deposits [50].…”

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

“…The formation of lipid nanostructured systems is controlled by soft interactions that regulate their colloidal stability in harsh bio-environments thus allowing a better control over their nanostructure [149][150][151][152]. For these reasons, lipid nanostructures are considered a versatile nano-platform in the field of nanomedicine and biotechnology [153,154]. Recently, a P3 lipopolymer (comprising of prostate-specific membrane antigen (PSMA) ligand, polyethylene glycol (PEG2000), and palmitate) was employed for the functionalization of liposomes for the targeted delivery of drugs and diagnostics to PSMA+ advanced/metastatic prostate tumors [155].…”